Search Results - "Yu, Shengyong"
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SS18 regulates pluripotent-somatic transition through phase separation
Published in Nature communications (02-07-2021)“…The transition from pluripotent to somatic states marks a critical event in mammalian development, but remains largely unresolved. Here we report the…”
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2
Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency
Published in Cell stem cell (05-04-2018)“…Despite its exciting potential, chemical induction of pluripotency (CIP) efficiency remains low and the mechanisms are poorly understood. We report the…”
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3
BMP4 drives primed to naïve transition through PGC-like state
Published in Nature communications (19-05-2022)“…Multiple pluripotent states have been described in mouse and human stem cells. Here, we apply single-cell RNA-seq to a newly established BMP4 induced mouse…”
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4
BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling
Published in Nature cell biology (01-06-2020)“…BMP4 regulates a plethora of developmental processes, including the dorsal–ventral axis and neural patterning. Here, we report that BMP4 reconfigures the…”
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5
Integrative functional analysis of super enhancer SNPs for coronary artery disease
Published in Journal of human genetics (01-05-2018)“…Clinical research in coronary artery disease (CAD) primarily focused on genetic variants located in protein-coding regions. Recently, mutations fall within…”
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Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4
Published in Cell reports (Cambridge) (18-06-2019)“…Reprogramming somatic cells to pluripotency by Oct4, Sox2, Klf4, and Myc represent a paradigm for cell fate determination. Here, we report a combination of…”
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7
Static Magnetic Fields Regulate T-Type Calcium Ion Channels and Mediate Mesenchymal Stem Cells Proliferation
Published in Cells (Basel, Switzerland) (08-08-2022)“…The static magnetic fields (SMFs) impact on biological systems, induce a variety of biological responses, and have been applied to the clinical treatment of…”
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8
Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function
Published in Cell reports (Cambridge) (21-11-2017)“…Polycomb repressive complex 1 (PRC1) plays essential roles in cell-fate determination. Recent studies have found that the composition of mammalian PRC1 is…”
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9
Forkhead box family transcription factors as versatile regulators for cellular reprogramming to pluripotency
Published in Cell regeneration (02-07-2021)“…Forkhead box (Fox) transcription factors play important roles in mammalian development and disease. However, their function in mouse somatic cell reprogramming…”
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10
Establishment and Identification of a CiPSC Lineage Reprogrammed from FSP-tdTomato Mouse Embryonic Fibroblasts (MEFs)
Published in Stem cells international (01-01-2018)“…Safety issues associated with transcription factors or viruses may be avoided with the use of chemically induced pluripotent stem cells (CiPSCs), thus…”
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11
The oncogene c-Jun impedes somatic cell reprogramming
Published in Nature cell biology (01-07-2015)“…Oncogenic transcription factors are known to mediate the conversion of somatic cells to tumour or induced pluripotent stem cells (iPSCs). Here we report c-Jun…”
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12
Regeneration of the human segmentation clock in somitoids in vitro
Published in The EMBO journal (01-12-2022)“…Each vertebrate species appears to have a unique timing mechanism for forming somites along the vertebral column, and the process in human remains poorly…”
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13
Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage
Published in The Journal of biological chemistry (17-11-2017)“…We report here an approach to redirecting somatic cell fate under chemically defined conditions without transcription factors. We start by converting mouse…”
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14
Corrigendum: The oncogene c-Jun impedes somatic cell reprogramming
Published in Nature cell biology (01-09-2015)Get full text
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15
Erratum: Corrigendum: The oncogene c-Jun impedes somatic cell reprogramming
Published in Nature cell biology (28-08-2015)Get full text
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Correction: Corrigendum: The oncogene c-Jun impedes somatic cell reprogramming
Published in Nature cell biology (2015)“…Nat. Cell Biol. 17, 856–867 (2015); published online 22 June 2015; corrected after print 10 August 2015 In the version of this Article originally published,…”
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