Search Results - "Yu, Rutong"

Radiation-induced YAP activation confers glioma radioresistance via promoting FGF2 transcription and DNA damage repair by Zhang, Yu, Wang, Yan, Zhou, Ding, Wang, Kai, Wang, Xu, Wang, Xiang, Jiang, Yang, Zhao, Min, Yu, Rutong, Zhou, Xiuping

“…Although radiotherapy is a well-known effective non-surgical treatment for malignant gliomas, the therapeutic efficacy is severely limited due to the…”
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Development of a hypoxia-triggered and hypoxic radiosensitized liposome as a doxorubicin carrier to promote synergetic chemo-/radio-therapy for glioma by Liu, Hongmei, Xie, Yandong, Zhang, Yafei, Cai, Yifan, Li, Baiyang, Mao, Honglin, Liu, Yingguo, Lu, Jun, Zhang, Longzhen, Yu, Rutong

“…Abstract The treatment of malignant primary brain tumors is challenging. Concomitant radiochemotherapy has become the standard clinical treatment for malignant…”
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ITGA1 Promotes Glioma Cell Proliferation and Affects Immune Cell Infiltration in Low‐Grade Glioma by Ren, Yanhong, Xu, Jianchang, Zhang, Zhengkui, Yu, Rutong

“…Background: Low‐grade glioma (LGG) is a commonly occurring type of central nervous system cancer. Integrin α1 (ITGA1), a family member of integrins, is implied…”
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Self-assembled angiopep-2 modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles delivery TMZ for glioma synergistic TMZ and RT therapy by Zong, Zhenkun, Hua, Lei, Wang, Zhen, Xu, Haoyue, Ye, Chengkun, Pan, Bomin, Zhao, Zongren, Zhang, Longzhen, Lu, Jun, Liu, Hongmei, Yu, Rutong

“…The addition of temozolomide (TMZ) to radiotherapy (RT) improves survival of patients with glioblastoma (GBM). However, TMZ + RT causes excess toxicity in…”
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YAP promotes autophagy and progression of gliomas via upregulating HMGB1 by Zhao, Min, Zhang, Yu, Jiang, Yang, Wang, Kai, Wang, Xiang, Zhou, Ding, Wang, Yan, Yu, Rutong, Zhou, Xiuping

“…Due to the hypoxia and nutrient deficiency microenvironment, glioblastoma (GBM) exhibits high autophagy activity and autophagy plays an important role in the…”
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Co-delivery of GOLPH3 siRNA and gefitinib by cationic lipid-PLGA nanoparticles improves EGFR-targeted therapy for glioma by Ye, Chengkun, Pan, Bomin, Xu, Haoyue, Zhao, Zongren, Shen, Jiawei, Lu, Jun, Yu, Rutong, Liu, Hongmei

“…Glioblastoma is one of the most aggressive types of brain tumor. Epidermal growth factor receptors (EGFRs) are overexpressed in glioma, and EGFR amplifications…”
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The third-generation EGFR inhibitor AZD9291 overcomes primary resistance by continuously blocking ERK signaling in glioblastoma by Liu, Xuejiao, Chen, Xiangyu, Shi, Lin, Shan, Qianqian, Cao, Qiyu, Yue, Chenglong, Li, Huan, Li, Shengsheng, Wang, Jie, Gao, Shangfeng, Niu, Mingshan, Yu, Rutong

“…Glioblastoma (GBM) is a fatal brain tumor, lacking effective treatment. Epidermal growth factor receptor (EGFR) is recognized as an attractive target for GBM…”
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Sitagliptin inhibits the survival, stemness and autophagy of glioma cells, and enhances temozolomide cytotoxicity by You, Fangting, Li, Cheng, Zhang, Shicheng, Zhang, Qiaoshan, Hu, Zhiyuan, Wang, Yuhui, Zhang, Tong, Meng, Qingming, Yu, Rutong, Gao, Shangfeng

“…The standard regimen treatment has improved GBM outcomes, but the survival rate of patients is still unsatisfactory. Temozolomide (TMZ) resistance is one of…”
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Application of New Radiosensitizer Based on Nano-Biotechnology in the Treatment of Glioma by Xie, Yandong, Han, Yuhan, Zhang, Xuefeng, Ma, Hongwei, Li, Linfeng, Yu, Rutong, Liu, Hongmei

“…Glioma is the most common intracranial malignant tumor, and its specific pathogenesis has been unclear, which has always been an unresolved clinical problem…”
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β-catenin-mediated YAP signaling promotes human glioma growth by Wang, Yan, Pan, Peng, Wang, Zhaohao, Zhang, Yu, Xie, Peng, Geng, Decheng, Jiang, Yang, Yu, Rutong, Zhou, Xiuping

“…Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression.We and…”
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The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma by Xu, Haoyue, Zhang, Yongkang, Li, Linfeng, Ren, Yanhong, Qian, Feng, Wang, Lansheng, Ma, Hongwei, Quan, Ankang, Liu, Hongmei, Yu, Rutong

“…Temozolomide (TMZ) is a conventional chemotherapeutic drug for glioma, however, its clinical application and efficacy is severely restricted by its drug…”
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GOLPH3 Regulates Exosome miRNA Secretion in Glioma Cells by Hu, Pengfei, Wang, Kai, Zhou, Ding, Wang, Liang, Zhao, Min, Wang, Weibing, Zhang, Yu, Liu, Yushuai, Yu, Rutong, Zhou, Xiuping

“…We aimed to examine whether golgi protein GOLPH3 could affect the secretion of glioma cell-derived exosomes. The exosomes were extracted by…”
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RIOK2 is negatively regulated by miR‐4744 and promotes glioma cell migration/invasion through epithelial‐mesenchymal transition by Song, Yunnong, Li, Cheng, Jin, Lei, Xing, Jingsong, Sha, Zhuang, Zhang, Tong, Ji, Daofei, Yu, Rutong, Gao, Shangfeng

“…RIOK2 is a member of RIO (right open reading frame) kinase family. Recent studies have revealed the involvement of RIO kinases in glioma cell growth and…”
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A multicenter, prospective, randomized clinical study to evaluate the efficacy and safety of fibrin sealant as an adjunct to sutured dural repair by Yu, Rutong, Zhu, Wei, Kocharian, Richard, Ilie, Bogdan, Wang, Zhong, Kang, Dezhi, Zhao, Gang, Yang, Hua, Shu, Kai, Liu, Xianzhi, Ke, Yiquan, Qu, Shun, Mao, Ying

“…The two-sided 95% CI for the difference in success rates using the Normal approximation Z (pooled) statistic was 37.3% and 59.9%. Since the lower limit of the…”
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PBX2-Mediated circTLK1 Activates JAK/STAT Signaling to Promote Gliomagenesis via miR-452-5p/SSR1 Axis by Li, Jing, Zhao, Zongren, Wang, Xiang, Ma, Qiong, Ji, Huanhuan, Wang, Yan, Yu, Rutong

“…Glioma is considered one of the most lethal brain tumors, as the aggressive blood vessel formation leads to high morbidity and mortality rates. However, the…”
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Preclinical evaluation of Mito-LND, a targeting mitochondrial metabolism inhibitor, for glioblastoma treatment by Guo, Tongxuan, Wu, Changyong, Zhou, Lingni, Zhang, Junhao, Wang, Wanzhou, Shen, Yang, Zhang, Ludong, Niu, Mingshan, Zhang, Xu, Yu, Rutong, Liu, Xuejiao

“…Glioblastoma (GBM) is a brain tumor with the highest level of malignancy and the worst prognosis in the central nervous system. Mitochondrial metabolism plays…”
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Dual blockade of EGFR and PI3K signaling pathways offers a therapeutic strategy for glioblastoma by Guo, Tongxuan, Wu, Changyong, Zhang, Junhao, Yu, Jiefeng, Li, Guoxi, Jiang, Hongyan, Zhang, Xu, Yu, Rutong, Liu, Xuejiao

“…Glioblastoma multiforme (GBM) is a devastating disease that lacks effective drugs for targeted therapy. Previously, we found that the third-generation…”
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Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression by Niu, Mingshan, Cai, Wei, Liu, Huize, Chong, Yulong, Hu, Wenqiang, Gao, Shangfeng, Shi, Qiong, Zhou, Xiuping, Liu, Xuejiao, Yu, Rutong

“…Plumbagin is a natural compound that is isolated from the root of the medicinal plant Plumbago zeylanica L. Based on a previous in vitro study performed by our…”
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Multi-responsive nanofibers composite gel for local drug delivery to inhibit recurrence of glioma after operation by Zhu, Yufu, Jia, Jun, Zhao, Gang, Huang, Xuyang, Wang, Lansheng, Zhang, Yongkang, Zhang, Long, Konduru, Naveena, Xie, Jun, Yu, Rutong, Liu, Hongmei

“…Abstract Background The postoperative recurrence of malignant gliomas has presented a clinical conundrum currently. Worse, there is no standard treatment for…”
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MELK Inhibition Effectively Suppresses Growth of Glioblastoma and Cancer Stem-Like Cells by Blocking AKT and FOXM1 Pathways by Zhang, Xu, Wang, Jie, Wang, Yifeng, Liu, Guanzheng, Li, Huan, Yu, Jiefeng, Wu, Runqiu, Liang, Jun, Yu, Rutong, Liu, Xuejiao

“…Glioblastoma multiforme (GBM) is a devastating disease yet no effective drug treatment has been established to date. Glioblastoma stem-like cells (GSCs) are…”
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