Search Results - "Yu, Luke (Zhaoxue)"

Abstract 497: Human CD73 knock-in mice facilitate evaluation of in vivo efficacy of anti-human CD73 cancer immunotherapies by Shang, Chengzhang, Li, Huilin, Zhang, Jing, Lin, Eugene, Yu, Luke (Zhaoxue), Shen, Yuelei

“…Abstract In recent years, immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. However, most patients with solid cancers do not respond to…”
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Abstract 1771: SIGLEC15 humanized knock-in mice are a powerful tool to evaluate new therapies for cancer and osteoporosis by Li, Huilin, Zhao, Lei, Tian, Maopeng, Chromikova, Veronika, Yu, Zhaoxue (Luke)

“…Abstract SIGLEC15 (Sialic acid-binding immunoglobulin-like lectin 15) belongs to the Siglec family of sialic acid-binding, immunoglobulin-like proteins…”
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Abstract 493: A novel humanized B-hPD-1/hPD-L1/hTIGIT mouse model reveals enhanced efficacy of combined TIGIT and PD-L1 blockade against cancer by Liu, Chonghui, Zhou, Xiaofei, Guo, Yanan, Lin, Eugene, Yu, Luke (Zhaoxue), Shen, Yuelei

“…Abstract Immune checkpoint blockade targeting PD-1/PD-L1 has enjoyed tremendous success in the clinic against various advanced stage cancers, unleashing potent…”
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Abstract 496: Humanized SIRPA and double humanized SIRPA/CD47 B-NDG mouse models are promising tools for anti-SIRPα antibody in vivo efficacy studies by Hu, Yuting, Zhao, Lei, Liu, Yujie, Hui, Li, Yu, Zhaoxue (Luke)

“…Abstract The CD47/Signal regulatory protein α (SIRPα) axis regulates myeloid cell activation and functions as a crucial myeloid specific immune checkpoint…”
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Abstract 2945: Novel engineered B-NDG B2M/KO mice plus and steroid treated B-NDG Mice shows delayed GvHD response when engrafted with hPBMC by Gao, Lan, Sharma, Shruti, Lin, Eugene, Wang, Xiaoen, Shang, Chengzhang, Hu, Yuting, An, W. Frank, Chawla, Mehma Kaur, Li, Kaiqi, Lin, Qingcong, Yu, Zhaoxue (Luke), Liu, Yujie

“…Abstract Severely immunodeficient mouse strains, such as NOD.Cg-Prkdcscid Il2rg-/-, have been used to study the immune response in humans. These mice lack T, B…”
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Abstract 2089: Evaluating in vivo efficacy of anti-TSLP antibodies in humanized B-hTSLP/hTSLPR mice by Zhang, Shujin, Nie, Yanhui, Chang, Jiahui, Chromikova, Veronika, Yu, Luke (Zhaoxue), Kuraguchi, Mari

“…Abstract Expression of the epithelial cytokine, thymic stromal lymphopoietin (TSLP), has been observed across several barrier surfaces and plays a critical…”
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Abstract 1648: Evaluation of therapeutic drug candidates using a novel humanized B-hCSF1/hCSF1R mouse model by Lyu, Ruili, Zhang, Shujin, Soto, Rebecca, Zhao, Suman, Liu, Chonghui, Yu, Luke (Zhaoxue)

“…Abstract An often rate-limiting step for cancer immunotherapy is drug development. The generation of humanized mouse models can be used to assess the clinical…”
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Abstract 1652: A humanized mouse model of the promising immune checkpoint molecule B7-H4 by Lyu, Ruili, Liu, Chonghui, Charpentier, John, Zhao, Suman, Yu, Luke (Zhaoxue)

“…Abstract B7-H4, a member of the B7-family of immune-regulatory ligands, has emerged in recent years as a promising target for immune checkpoint therapy…”
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Abstract 2907: 1C3, a Novel non-blocking anti-human TNFR2 antibody generated from RenMice, exhibits promising anti-tumor activity and safety in syngeneic tumor models in humanized TNFR2 mice by Yang, Yongfei, Cao, Shuzhen, Zhang, Jing, Shao, Zhe, Jiang, Xueyuan, Duan, Qingya, Tian, Maopeng, Mei, Sen, Yu, Luke (Zhaoxue)

“…Abstract Regulatory T Cells (Treg) inhibit effector T cell (Teff) activity in the tumor microenvironment (TME). Therefore, depletion of regulatory T cells…”
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