Search Results - "Yu, Ian"
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Nonaspirin nonsteroidal anti‐inflammatory drugs and gastric cancer risk after Helicobacter pylori eradication: A territory‐wide study
Published in Cancer (01-06-2021)“…Background Despite Helicobacter pylori (HP) eradication, individuals can still develop gastric cancer (GC). Prior studies have demonstrated that nonaspirin…”
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Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release
Published in eLife (26-02-2020)“…The supramammillary nucleus (SuM) provides substantial innervation to the dentate gyrus (DG). It remains unknown how the SuM and DG coordinate their activities…”
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Calcium channel blockers are associated with lower gastric cancer risk: A territory‐wide study with propensity score analysis
Published in International journal of cancer (01-05-2021)“…Prior studies showed that calcium channel blockers (CCBs) could modify cancer risk, but data on gastric cancer (GC) are limited. We aimed to investigate…”
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Superoxide free radical spin‐lattice relaxivity: A quench‐assisted MR study
Published in Magnetic resonance in medicine (01-08-2021)“…Purpose QuEnch‐assiSTed (QUEST) MRI provides a unique biomarker of excessive production of paramagnetic free radicals (oxidative stress) in vivo. The…”
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Loss of Brain Norepinephrine Elicits Neuroinflammation-Mediated Oxidative Injury and Selective Caudo-Rostral Neurodegeneration
Published in Molecular neurobiology (01-04-2019)“…Environmental toxicant exposure has been strongly implicated in the pathogenesis of Parkinson’s disease (PD). Clinical manifestations of non-motor and motor…”
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Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the salience network
Published in Nature communications (16-02-2023)“…The salience network (SN) and default mode network (DMN) play a crucial role in cognitive function. The SN, anchored in the anterior insular cortex (AI), has…”
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Programing of an Intravascular Immune Firewall by the Gut Microbiota Protects against Pathogen Dissemination during Infection
Published in Cell host & microbe (11-11-2020)“…Eradication of pathogens from the bloodstream is critical to prevent disseminated infections and sepsis. Kupffer cells in the liver form an intravascular…”
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Multidrug-resistant E. coli encoding high genetic diversity in carbohydrate metabolism genes displace commensal E. coli from the intestinal tract
Published in PLoS biology (17-10-2023)“…Extra-intestinal pathogenic Escherichia coli (ExPEC) can cause a variety of infections outside of the intestine and are a major causative agent of urinary…”
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Simultaneous fMRI and fast-scan cyclic voltammetry bridges evoked oxygen and neurotransmitter dynamics across spatiotemporal scales
Published in NeuroImage (Orlando, Fla.) (01-12-2021)“…•By modifying FSCV components, simultaneous fMRI data can be acquired with minimal imaging artifacts.•We detect and quantify evoked dopamine and/or tissue…”
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Mitochondriotropic lanthanide nanorods: implications for multimodal imaging
Published in Chemical communications (Cambridge, England) (21-07-2020)“…Two-photon active mitochondriotropic lanthanide nanorods for high resolution fluorescence imaging. The presence of Gd in the nanorods also enabled us to…”
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Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections
Published in Nature medicine (01-04-2023)“…Critically ill patients in intensive care units experience profound alterations of their gut microbiota that have been linked to a high risk of…”
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Intrinsic Functional Connectivity between the Anterior Insular and Retrosplenial Cortex as a Moderator and Consequence of Cocaine Self-Administration in Rats
Published in The Journal of neuroscience (14-02-2024)“…While functional brain imaging studies in humans suggest that chronic cocaine use alters functional connectivity (FC) within and between key large-scale brain…”
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Genetic identification of a population of noradrenergic neurons implicated in attenuation of stress-related responses
Published in Molecular psychiatry (01-05-2019)“…Noradrenergic signaling plays a well-established role in promoting the stress response. Here we identify a subpopulation of noradrenergic neurons, defined by…”
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Complement receptor 3-mediated neurotoxic glial activation contributes to rotenone-induced cognitive decline in mice
Published in Ecotoxicology and environmental safety (01-11-2023)“…Microglia-mediated chronic neuroinflammation has been associated with cognitive decline induced by rotenone, a well-known neurotoxic pesticide used in…”
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Combining optogenetic stimulation and fMRI to validate a multivariate dynamical systems model for estimating causal brain interactions
Published in NeuroImage (Orlando, Fla.) (15-05-2016)“…State-space multivariate dynamical systems (MDS) (Ryali et al. 2011) and other causal estimation models are being increasingly used to identify directed…”
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Adolescent alcohol exposure decreases frontostriatal resting‐state functional connectivity in adulthood
Published in Addiction biology (01-03-2018)“…Connectivity of the prefrontal cortex (PFC) matures through adolescence, coinciding with emergence of adult executive function and top‐down inhibitory control…”
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Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer's mouse model
Published in Journal of translational medicine (15-04-2023)“…Alzheimer's disease (AD) is characterized by a progressive loss of memory that cannot be efficiently managed by currently available AD therapeutics. So far,…”
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Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
Published in Nature communications (08-01-2021)“…Understanding the factors that contribute to efficient SARS-CoV-2 infection of human cells may provide insights on SARS-CoV-2 transmissibility and…”
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One-pot synthesis of carboxymethyl-dextran coated iron oxide nanoparticles (CION) for preclinical fMRI and MRA applications
Published in NeuroImage (Orlando, Fla.) (01-09-2021)“…•We developed and validated Carboxymethyl-dextran coated iron oxide nanoparticles (CION).•We disseminated a step-by-step protocol of our one-pot,…”
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General Anesthesia Versus Local Anesthesia in Carotid Endarterectomy: A Systematic Review and Meta-Analysis
Published in Journal of cardiothoracic and vascular anesthesia (01-01-2020)“…The choice of anesthetic technique in carotid endarterectomy (CEA) has been controversial. This study compared the outcomes of general anesthesia (GA) and…”
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