Search Results - "Yu, HyunKyung"
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Mechanisms of carvacrol-induced expression of type I collagen gene
Published in Journal of dermatological science (01-12-2008)“…Summary Background Skin aging is accompanied by wrinkle formation and appears to be principally related to decreases in the levels of type I collagen, the…”
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Treatment of experimental human breast cancer and lung cancer brain metastases in mice by macitentan, a dual antagonist of endothelin receptors, combined with paclitaxel
Published in Neuro-oncology (Charlottesville, Va.) (01-04-2016)“…We recently demonstrated that brain endothelial cells and astrocytes protect cancer cells from chemotherapy through an endothelin-dependent signaling…”
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Abstract 553: Assessment of CNTN4 expression and its association with PD-L1 across 18 various cancers using an artificial intelligence-powered immunohistochemistry analyzer
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Background: Contactin-4 (CNTN4) has been identified as an inhibitory immune checkpoint protein and mainly expressed on tumor cells. It interacts with APP…”
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Abstract 740: CNTN4 as a novel target for solid cancer with antibody-drug conjugate
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…As a novel immune checkpoint, we previously confirmed that contactin 4 (CNTN4) regulates T cell activity negatively by binding to amyloid precursor protein…”
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Contactin-4 suppresses antitumor T cell responses by engaging amyloid precursor protein
Published in Science immunology (11-10-2024)“…Immune checkpoint inhibitors have substantial advanced tumor treatment, but their limited benefits and strong responses in only a subset of patients remain…”
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Abstract 804: Antitumor activity of the potent and novel FLT3 inhibitor HM43239 in acute myeloid leukemia
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Introduction: Acute myeloid leukemia (AML) with FMS-like tyrosine kinase 3 (FLT3) mutations is associated with poor prognosis with a high risk of relapse after…”
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Abstract 1868: Novel immune checkpoint inhibitor: In vivo and in vitro efficacy of anti-CNTN4 antibody, GENA-104A16 in the models with increased CNTN4 expression
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…We previously suggested that contactin 4 (CNTN4) negatively regulates T cell activity through binding with amyloid precursor protein on T cells. In addition,…”
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Abstract 2968: Development of anti-APP antibody targeting APP/CNTN4 axis as a novel cancer immunotherapy
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Immunotherapeutic treatment has profoundly improved the clinical outcomes in patients with advanced cancers. However, most patients still have not responded to…”
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Abstract 4780: A novel, potent and selective FGFR4 inhibitor, HM81422 in hepatocellular carcinoma with FGFR4-driven pathway activation
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Introduction: Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer and the second most frequent cause of cancer-related death, however, treatment…”
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Abstract 1760: The antibody-drug conjugate GENA-111 conjugated to auristatin F shows therapeutic potency in BCAM positive epithelial cancer
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Antibody-drug conjugates (ADCs) are considered as promising cancer treatment modalities that combine the selectivity of antibodies and the cytotoxic properties…”
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Purification and partial peptide sequence analysis of the boar 32 kDa sperminogen
Published in Molecules and cells (31-08-2001)“…Boar 32 kDa sperminogen was purified from acid extracts of washed epididymal spermatozoa, and partial peptide sequence was determined. Boar sperminogen was…”
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