Search Results - "Yu, Dale K."

The Contribution of P-glycoprotein to Pharmacokinetic Drug-Drug Interactions by Yu, Dale K.

“…P‐glycoprotein (PGP) is well known because of its contribution to multiple‐drug resistance during anticancer treatment. More recent work indicates that PGP…”
Get full text

Effect of food coadministration on 5-aminosalicylic acid oral suspension bioavailability by Yu, D K, Elvin, A T, Morrill, B, Eichmeier, L S, Lanman, R C, Lanman, M B, Giesing, D H

“…Single doses of 1 gm 5-aminosalicylic acid (5-ASA) suspension was administered to 24 healthy volunteers during both fasting and fed conditions. For subjects in…”
Get more information

Pharmacokinetics of dothiepin in humans: a single dose dose-proportionality study by Yu, D K, Dimmitt, D C, Lanman, R C, Giesing, D H

“…Dothiepin hydrochloride (N,N-dimethyldibenzo[b,e]thiepin-delta 11(6 H), gamma-propylamine hydrochloride) is a tricyclic antidepressant which is structurally…”
Get more information

A limited sampling method for the estimation of vigabatrin maximum plasma concentration and area under the curve by TAMMARA, V, MAHMOOD, I, YU, D. K, HILEMAN, G. A

“…A limited sampling model (LSM) was developed to estimate the area under the curve (AUC) and maximum plasma concentration (Cmax) for a 1-g oral dose of…”
Get full text

Selection of Doses for Phase II Clinical Trials Based on Pharmacokinetic Variability Consideration by Yu, Dale K., Bhargava, Vijay O., Weir, Scott J.

“…Pharmacokinetic variability is an important component of the total variability in drug response, but Phase II dose‐response trials frequently are designed…”
Get full text

Pharmacokinetics of propylene glycol in humans during multiple dosing regimens by Yu, D K, Elmquist, W F, Sawchuk, R J

“…The pharmacokinetics of propylene glycol has been examined during multiple oral-dosing regimens. The glycol is rapidly absorbed, with Cpmax observed within 1 h…”
Get more information

A comparison of population and standard two-stage pharmacokinetic analyses of vigabatrin data by Yu, D K, Hutcheson, S J, Wei, G, Bhargava, V O, Weir, S J

“…Vigabatrin (VGB), an irreversible inhibitor of GABA, is being developed as an add-on therapy for uncontrolled complex partial seizure. A single-dose study was…”
Get more information

Population pharmacokinetics of teicoplanin in patients with endocarditis by Yu, D K, Nordbrock, E, Hutcheson, S J, Lewis, E W, Sullivan, W, Bhargava, V O, Weir, S J

“…Teicoplanin is a new glycopeptide antibiotic, active against aerobic and anaerobic gram-positive bacteria. The drug is intended for the treatment of systemic…”
Get more information

Pharmacokinetics of nitroglycerin and metabolites in humans following oral dosing by Yu, D K, Williams, R L, Benet, L Z, Lin, E T, Giesing, D H

“…Single dose oral nitroglycerin (GTN) was administered to six healthy subjects as 6.5, 9.0, and 13.0 mg aqueous solutions in sequential study phases to…”
Get more information

Pharmacokinetics of diltiazem and propranolol when administered alone and in combination by Dimmitt, D C, Yu, D K, Elvin, A T, Giesing, D H, Lanman, R C

“…Multiple oral doses of diltiazem (DTZ) and propranolol (PPL, 60 mg every 8 h daily for 13 doses) were administered to 14 healthy volunteers alone and in…”
Get more information

Pharmacokinetics of propylene glycol in the rabbit by Yu, D K, Sawchuk, R J

“…Propylene glycol (PG) is widely used as a drug solvent in the pharmaceutical industry. However, it has produced central nervous system toxicity during chronic…”
Get more information