Search Results - "Yu, Albert S."

Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury by Zong, Pengyu, Feng, Jianlin, Yue, Zhichao, Li, Yunfeng, Wu, Gongxiong, Sun, Baonan, He, Yanlin, Miller, Barbara, Yu, Albert S., Su, Zhongping, Xie, Jia, Mori, Yasuo, Hao, Bing, Yue, Lixia

“…Excitotoxicity induced by NMDA receptor (NMDAR) activation is a major cause of neuronal death in ischemic stroke. However, past efforts of directly targeting…”
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An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery by Zeng, Hui, Guo, Min, Zhou, Ting, Tan, Lei, Chong, Chi Nok, Zhang, Tuo, Dong, Xue, Xiang, Jenny Zhaoying, Yu, Albert S., Yue, Lixia, Qi, Qibin, Evans, Todd, Graumann, Johannes, Chen, Shuibing

“…Genome-wide association studies (GWASs) have increased our knowledge of loci associated with a range of human diseases. However, applying such findings to…”
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Role of TRP channels in the cardiovascular system by Yue, Zhichao, Xie, Jia, Yu, Albert S, Stock, Jonathan, Du, Jianyang, Yue, Lixia

“…The transient receptor potential (TRP) superfamily consists of a large number of nonselective cation channels with variable degree of Ca(2+)-permeability. The…”
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CNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells by Bai, Zhiyong, Feng, Jianlin, Franken, Gijs A C, Al'Saadi, Namariq, Cai, Na, Yu, Albert S, Lou, Liping, Komiya, Yuko, Hoenderop, Joost G J, de Baaij, Jeroen H F, Yue, Lixia, Runnels, Loren W

“…Magnesium is essential for cellular life, but how it is homeostatically controlled still remains poorly understood. Here, we report that members of CNNM…”
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Ca2+ Signaling in Cardiac Fibroblasts and Fibrosis-Associated Heart Diseases by Feng, Jianlin, Armillei, Maria K., Yu, Albert S., Liang, Bruce T., Runnels, Loren W., Yue, Lixia

“…Cardiac fibrosis is the excessive deposition of extracellular matrix proteins by cardiac fibroblasts and myofibroblasts, and is a hallmark feature of most…”
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Statin Use and Mortality among Patients Hospitalized with Sepsis: A Retrospective Cohort Study within Southern California, 2008–2018 by Liang, Brannen, Yang, Su-jau T., Wei, Kenneth K., Yu, Albert S., Kim, Brendan J., Gould, Michael K., Sim, John J.

“…Background. Despite early goal-directed therapy, sepsis mortality remains high. Statins exhibit pleiotropic effects. Objective. We sought to compare mortality…”
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Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia by Brown, Jennifer R., Byrd, John C., Coutre, Steven E., Benson, Don M., Flinn, Ian W., Wagner-Johnston, Nina D., Spurgeon, Stephen E., Kahl, Brad S., Bello, Celeste, Webb, Heather K., Johnson, Dave M., Peterman, Sissy, Li, Daniel, Jahn, Thomas M., Lannutti, Brian J., Ulrich, Roger G., Yu, Albert S., Miller, Langdon L., Furman, Richard R.

“…In a phase 1 trial, idelalisib (GS-1101, CAL-101), a selective inhibitor of the lipid kinase PI3Kδ, was evaluated in 54 patients with relapsed/refractory…”
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A phase 2 study of idelalisib plus rituximab in treatment-naïve older patients with chronic lymphocytic leukemia by O'Brien, Susan M., Lamanna, Nicole, Kipps, Thomas J., Flinn, Ian, Zelenetz, Andrew D., Burger, Jan A., Keating, Michael, Mitra, Siddhartha, Holes, Leanne, Yu, Albert S., Johnson, David M., Miller, Langdon L., Kim, Yeonhee, Dansey, Roger D., Dubowy, Ronald L., Coutre, Steven E.

“…Idelalisib is a first-in-class oral inhibitor of PI3Kδ that has shown substantial activity in patients with relapsed/refractory chronic lymphocytic leukemia…”
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Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-δ, as therapy for previously treated indolent non-Hodgkin lymphoma by Flinn, Ian W., Kahl, Brad S., Leonard, John P., Furman, Richard R., Brown, Jennifer R., Byrd, John C., Wagner-Johnston, Nina D., Coutre, Steve E., Benson, Don M., Peterman, Sissy, Cho, Yoonjin, Webb, Heather K., Johnson, David M., Yu, Albert S., Ulrich, Roger G., Godfrey, Wayne R., Miller, Langdon L., Spurgeon, Stephen E.

“…Idelalisib (GS-1101, CAL-101), an oral inhibitor of phosphatidylinositol 3-kinase-δ, was evaluated in a phase I study in 64 patients with relapsed indolent…”
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Intravesical resiniferatoxin for the treatment of interstitial cystitis: a randomized, double-blind, placebo controlled trial by Payne, Christopher K, Mosbaugh, Philip G, Forrest, John B, Evans, Robert J, Whitmore, Kristene E, Antoci, Joseph P, Perez-Marrero, Ramon, Jacoby, Karny, Diokno, Ananias C, O'Reilly, Keith J, Griebling, Tomas L, Vasavada, Sandip P, Yu, Albert S, Frumkin, Lyn R

“…Interstitial cystitis is a painful bladder condition of unknown etiology and poorly understood pathophysiology. Current therapies have met with limited…”
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Disease-Specific Factors Associated with Readmissions or Mortality After Hospital Discharge in COVID-19 Patients: a Retrospective Cohort Study by Huang, Cheng-Wei, Park, Joon S., Song, Hubert, Khang, Vang Kou, Yu, Albert S., Nguyen, Huong Q., Lee, Janet S., Subject, Christopher C., Shen, Ernest

“…Background Understanding the implications of disease-specific factors beyond baseline patient characteristics for coronavirus disease 2019 (COVID-19) may allow…”
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Identification of key amino acid residues responsible for internal and external pH sensitivity of Orai1/STIM1 channels by Tsujikawa, Hiroto, Yu, Albert S, Xie, Jia, Yue, Zhichao, Yang, Wenzhong, He, Yanlin, Yue, Lixia

“…Changes of intracellular and extracellular pH are involved in a variety of physiological and pathological processes, in which regulation of the Ca 2+ release…”
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All-Cause and Cardiovascular-Related Mortality in CKD Patients With and Without Heart Failure: A Population-Based Cohort Study in Kaiser Permanente Southern California by Yu, Albert S., Pak, Katherine J., Zhou, Hui, Shaw, Sally F., Shi, Jiaxiao, Broder, Benjamin I., Sim, John J.

“…Heart failure and chronic kidney disease (CKD) frequently coexist reflective of the strong interplay between these organ systems. A better understanding of the…”
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Real-world use patterns of angiotensin receptor-neprilysin inhibitor (sacubitril/valsartan) among patients with heart failure within a large integrated health system by Kim, Brendan J, Huang, Cheng-Wei, Chung, Joanie, Neyer, Jonathan R, Liang, Brannen, Yu, Albert S, Kwong, Eric K, Park, Joon S, Hung, Peggy, Sim, John J

“…Sacubitril/valsartan is a first-in-class angiotensin receptor-neprilysin inhibitor (ARNI) that is now preferred in guidelines over angiotensin-converting…”
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Effect of Recombinant Human Platelet-activating Factor-Acetylhydrolase on Allergen-induced Asthmatic Responses by HENIG, NOREEN R, AITKEN, MOIRA L, LIU, MARK C, YU, ALBERT S, HENDERSON, WILLIAM R., Jr

“…Platelet-activating factor (PAF) is a potent lipid mediator associated with key features of asthma such as airway constriction, eosinophil infiltration, edema,…”
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Statin use and survival among ESKD patients hospitalized with sepsis by Yu, Albert S, Liang, Brannen, Yang, Su-Jau T, Kim, Brendan J, Huang, Cheng-Wei, Sim, John J

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Identification and characterization of genes required for compensatory growth in Drosophila by Gerhold, Abigail R, Richter, Daniel J, Yu, Albert S, Hariharan, Iswar K

“…To maintain tissue homeostasis, some organs are able to replace dying cells with additional proliferation of surviving cells. Such proliferation can be…”
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Association Between Dexamethasone Treatment After Hospital Discharge for Patients With COVID-19 Infection and Rates of Hospital Readmission and Mortality by Huang, Cheng-Wei, Yu, Albert S, Song, Hubert, Park, Joon S, Wu, Stefanie S, Khang, Vang Kou, Subject, Christopher C, Shen, Ernest

“…Current guidelines recommend use of dexamethasone, 6 mg/d, up to 10 days or until discharge for patients hospitalized with COVID-19. Whether patients who…”
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Abstract 11314: Trpm2 Deletion Alleviates Atherosclerosis by Inhibiting the Activation of CD36 in Macrophages by Zong, Pengyu, Feng, Jianlin, Yue, Zhichao, Yu, Albert S, Yue, Lixia

“…IntroductionAtherosclerosis and its complications are the leading cause of death. The central pathological features of atherosclerosis are macrophage…”
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Abstract P3129: Functional Coupling Of TRPM2 And Extrasynaptic NMDARs Exacerbates Excitotoxicity In Ischemic Stroke by Zong, Pengyu, feng, jianlin, Yue, Zhichao, Li, Yunfeng, Wu, Gongxiong, Sun, Baonan, He, Yanlin, Miller, Barbara, Yu, Albert S, Su, Zhongping, Xie, Jia, Mori, Yasuo, Hao, Bing, Yue, Lixia

“…IntroductionIschemic stroke caused a heavy burden on public health. NMDA receptor (NMDAR) mediated excitotoxicity was thought to be the culprit for neuronal…”
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