Anti-nociceptive and anti-inflammatory activity of some (2-benzoxazolone-3-yl and 2-benzothiazolone-3-yl) acetic acid derivatives

Sixteen (2-benzothiazolone-3-yl and 2-benzoxazolone-3-yl) acetic acid derivatives 5 have been tested for anti-nociceptive and anti-inflammatory activity in this study. 4- [2-(6-Benzoyl-2-benzoxazolone-3-yl) acetyl] morpholine ( 5c), 4-(2- [ 6-(2-chloro-benzoyl)-2-benzoxazolone-3-yl]acetyl]morpholine...

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Bibliographic Details
Published in:	Farmaco (Società chimica italiana : 1989) Vol. 53; no. 1; pp. 80 - 84
Main Authors:	Dogruer, Deniz Songül, Ünlü, Serdar, Şahin, Mustafa Fethi, Yqilada, Erdem
Format:	Journal Article
Language:	English
Published:	France Elsevier SAS 01-01-1998
Subjects:	Analgesics, Non-Narcotic - chemical synthesis Analgesics, Non-Narcotic - pharmacology Animals Anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-nociceptive activity Benzothiazoles Benzothiazolinone derivatives Benzoxazoles - chemical synthesis Benzoxazoles - pharmacology Benzoxazolinone derivatives Female Male Mice Structure-Activity Relationship Thiazoles - chemical synthesis Thiazoles - pharmacology Anti-inflammatory activity Benzothiazolinone derivatives Benzoxazolinone derivatives Anti-nociceptive activity
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Summary:	Sixteen (2-benzothiazolone-3-yl and 2-benzoxazolone-3-yl) acetic acid derivatives 5 have been tested for anti-nociceptive and anti-inflammatory activity in this study. 4- [2-(6-Benzoyl-2-benzoxazolone-3-yl) acetyl] morpholine ( 5c), 4-(2- [ 6-(2-chloro-benzoyl)-2-benzoxazolone-3-yl]acetyl]morpholine ( 5d), 1-[2-(5-chloro-2-benzoxazolone-3-yl)acetyl]pyrrolidine ( 5f), methyl (6-methyl-2-benzoxazolone-3-yl) acetate ( 5k) and N, N-diethyl-2-(2-benzothiazolone-3-yl)acetamide ( 5m) have shown more potent anti-nociceptive activity than others. Among these compounds, 5c, 5d and 5m have exhibited good anti-inflammatory activity, with 5f, and to a lesser extent, the other molecules displaying some toxic potential.
ISSN:	0014-827X 1879-0569
DOI:	10.1016/S0014-827X(97)00017-7