Search Results - "Yoza, Barbara"

Sirtuins Link Inflammation and Metabolism by Yoza, Barbara K., Hoth, Jason J., Wang, Xianfeng, Liu, Tiefu, Vachharajani, Vidula, McCall, Charles E.

“…Sirtuins (SIRT), first discovered in yeast as NAD+ dependent epigenetic and metabolic regulators, have comparable activities in human physiology and disease…”
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Sirtuins and Immuno-Metabolism of Sepsis by Wang, Xianfeng, Buechler, Nancy L, Woodruff, Alan G, Long, David L, Zabalawi, Manal, Yoza, Barbara K, McCall, Charles E, Vachharajani, Vidula

“…Sepsis and septic shock are the leading causes of death in non-coronary intensive care units worldwide. During sepsis-associated immune dysfunction, the…”
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NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance by Liu, Tie Fu, Yoza, Barbara K., El Gazzar, Mohamed, Vachharajani, Vidula T., McCall, Charles E.

“…Gene-selective epigenetic reprogramming and shifts in cellular bioenergetics develop when Toll-like receptors (TLR) recognize and respond to systemic…”
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Frontline Science: Monocytes sequentially rewire metabolism and bioenergetics during an acute inflammatory response by Zhu, Xuewei, Meyers, Allison, Long, David, Ingram, Brian, Liu, Tiefu, Yoza, Barbara K., Vachharajani, Vidula, McCall, Charles E.

“…Metabolism directs the severe acute inflammatory reaction of monocytes to guard homeostasis. This occurs by sequentially activating anabolic immune effector…”
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The NF-κB Factor RelB and Histone H3 Lysine Methyltransferase G9a Directly Interact to Generate Epigenetic Silencing in Endotoxin Tolerance by Chen, Xiaoping, El Gazzar, Mohamed, Yoza, Barbara K., McCall, Charles E.

“…The interplay of transcription factors, histone modifiers, and DNA modification can alter chromatin structure that epigenetically controls gene transcription…”
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Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes by Zhu, Xuewei, Long, David, Zabalawi, Manal, Ingram, Brian, Yoza, Barbara K., Stacpoole, Peter W., McCall, Charles E.

“…The pyruvate dehydrogenase complex (PDC)/pyruvate dehydrogenase kinase (PDK) axis directs the universal survival principles of immune resistance and tolerance…”
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SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome by Vachharajani, Vidula T., Liu, Tiefu, Brown, Candice M., Wang, Xianfeng, Buechler, Nancy L., Wells, Jonathan David, Yoza, Barbara K., McCall, Charles E.

“…Proinflammatory effects of SIRT1 inhibition exerts phase specific changes with decreased survival during hyper‐inflammation, and increased survival during…”
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Sepsis, pyruvate, and mitochondria energy supply chain shortage by McCall, Charles E., Zhu, Xuewei, Zabalawi, Manal, Long, David, Quinn, Matthew A., Yoza, Barbara K., Stacpoole, Peter W., Vachharajani, Vidula

“…Balancing high energy‐consuming danger resistance and low energy supply of disease tolerance is a universal survival principle that often fails during sepsis…”
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Resveratrol attenuates microvascular inflammation in sepsis via SIRT‐1‐Induced modulation of adhesion molecules in ob/ob mice by Wang, Xianfeng, Buechler, Nancy L., Yoza, Barbara K., McCall, Charles E., Vachharajani, Vidula T.

“…Objective Obesity, a sirtuin‐1 (SIRT‐1) ‐deficient state, increases morbidity and resource utilization in critically ill patients. SIRT‐1 deficiency increases…”
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Fueling the flame: bioenergy couples metabolism and inflammation by Liu, Tie Fu, Brown, Candice M., El Gazzar, Mohamed, McPhail, Linda, Millet, Patrick, Rao, Anuradha, Vachharajani, Vidula T., Yoza, Barbara K., McCall, Charles E.

“…Review on how the integration of bioenergetics and metabolism controls inflammation progression. We review the emerging concept that changes in cellular…”
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SIRT1 Mediates Septic Cardiomyopathy in a Murine Model of Polymicrobial Sepsis by Smith, Lane M., Yoza, Barbara K., Hoth, J. Jason, McCall, Charles E., Vachharajani, Vidula

“…BACKGROUND:Cardiac dysfunction, a common complication from severe sepsis, is associated with increased morbidity and mortality. However, the molecular…”
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G9a and HP1 Couple Histone and DNA Methylation to TNFα Transcription Silencing during Endotoxin Tolerance by Gazzar, Mohamed El, Yoza, Barbara K., Chen, Xiaoping, Hu, Jean, Hawkins, Gregory A., McCall, Charles E.

“…TNFα gene expression is silenced in the endotoxin tolerant phenotype that develops in blood leukocytes after the initial activation phase of severe systemic…”
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Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice by Wang, Xianfeng, Buechler, Nancy L, Martin, Ayana, Wells, Jonathan, Yoza, Barbara, McCall, Charles E, Vachharajani, Vidula

“…Obesity increases morbidity and resource utilization in sepsis patients. Sepsis transitions from early/hyper-inflammatory to late/hypo-inflammatory phase…”
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The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat by Long, David, Wu, Hanzhi, Tsang, Allen W., Poole, Leslie B., Yoza, Barbara K., Wang, Xianfeng, Vachharajani, Vidula, Furdui, Cristina M., McCall, Charles E.

“…Control of glucose homeostasis plays a critical role in health and lifespan and its dysregulation contributes to inflammation, cancer and aging. NAD +…”
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Chromatin-Specific Remodeling by HMGB1 and Linker Histone H1 Silences Proinflammatory Genes during Endotoxin Tolerance by Gazzar, Mohamed El, Yoza, Barbara K., Chen, Xiaoping, Garcia, Benjamin A., Young, Nicolas L., McCall, Charles E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis by Wang, Xianfeng, Buechler, Nancy L., Long, David L., Furdui, Cristina M., Yoza, Barbara K., McCall, Charles E., Vachharajani, Vidula

“…Obesity increases morbidity and mortality in acute illnesses such as sepsis and septic shock. We showed previously that the early/hyper-inflammatory phase of…”
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NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response by Liu, Tie Fu, Vachharajani, Vidula T., Yoza, Barbara K., McCall, Charles E.

“…Background: Switching from the acute early initiation to late adaptation response after TLR4 stimulation depends on SirT1. Results: Switching from glucose to…”
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Sirtuin 2 Regulates Microvascular Inflammation during Sepsis by McCall, Charles E., Yoza, Barbara K., Wang, Xianfeng, Buechler, Nancy, Vachharajani, Vidula

“…Objective. Sepsis and septic shock, the leading causes of death in noncoronary intensive care units, kill more than 200,000/year in the US alone. Circulating…”
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Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice by Vachharajani, Vidula, Yoza, Barbara K., Alexander-Miller, Martha, Martin, Ayana N., McCall, Charles E.

“…Resistance and tolerance to infection are two universal fitness and survival strategies used by inflammation and immunity in organisms and cells to guard…”
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Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation by McCall, Charles E., El Gazzar, Mohamed, Liu, Tiefu, Vachharajani, Vidula, Yoza, Barbara

“…NAD+‐dependent bioenergetics integrate with epigenetic‐dependent regulation of proteins and microRNAs to guide the course of acute systemic inflammation. Acute…”
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