Search Results - "Youssif, Bahaa G.M."

Synthesis and biological evaluation of novel xanthine derivatives as potential apoptotic antitumor agents by Hisham, Mohamed, Youssif, Bahaa G.M., Osman, Essam Eldin A., Hayallah, Alaa M., Abdel-Aziz, Mohamed

“…A series of novel xanthine/NO donor hybrids containing 1,3,8-trisubstituted or 1,8-disubstituted xanthine derivatives were designed and synthesized. The…”
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EGFR inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and docking studies of novel xanthine derivatives carrying chalcone moiety as hybrid molecules by Abou-Zied, Hesham A., Youssif, Bahaa G.M., Mohamed, Mamdouh F.A., Hayallah, Alaa M., Abdel-Aziz, Mohamed

“…[Display omitted] •A series of 20 novel compounds contain xanthine-chalcone hybrid was designed and synthesized.•The synthesized hybrids were evaluated against…”
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Structure-based design, synthesis and antiproliferative action of new quinazoline-4-one/chalcone hybrids as EGFR inhibitors by Hisham, Mohamed, Hassan, Heba A., Gomaa, Hesham A.M., Youssif, Bahaa G.M., Hayallah, Alaa M., Abdel-Aziz, Mohamed

“…•A series of novel quinazoline-4-one/chalcone hybrids as EGFR inhibitors has been designed and synthesized.•Compounds 19, 20, and 22 were the most active…”
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5-Chlorobenzofuran-2-carboxamides: From allosteric CB1 modulators to potential apoptotic antitumor agents by Youssif, Bahaa G.M., Mohamed, Ashraf M., Osman, Essam Eldin A., Abou-Ghadir, Ola F., Elnaggar, Dina H., Abdelrahman, Mostafa H., Treamblu, Laurent, Gomaa, Hesham A.M.

“…Cannabinoids as THC and the CB1 allosteric modulator CBD were reported to have antiproliferative activities with no reports for other CB1 allosteric modulators…”
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Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance by Zha, Gao-Feng, Qin, Hua-Li, Youssif, Bahaa G.M., Amjad, Muhammad Wahab, Raja, Maria Abdul Ghafoor, Abdelazeem, Ahmed H., Bukhari, Syed Nasir Abbas

“…The drug research and development nowadays is focusing on multi-target drugs. In the treatment of cancer, therapies using drugs inhibiting one numerous targets…”
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Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production by Youssif, Bahaa G.M., Abdelrahman, Mostafa H., Abdelazeem, Ahmed H., abdelgawad, Mohamed A., Ibrahim, Hussein M., Salem, Ola I.A., Mohamed, Mamdouh F.A., Treambleau, Laurent, Bukhari, Syed Nasir Abbas

“…A series of novel compounds carrying pyrazino[1,2-a]indol-1(2H)-one scaffold (5a-g) and their reaction intermediates, indole-2-carboxamides, (3a-g) were…”
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Linseed hydrogel-mediated green synthesis of silver nanoparticles for antimicrobial and wound-dressing applications by Haseeb, Muhammad Tahir, Hussain, Muhammad Ajaz, Abbas, Khawar, Youssif, Bahaa Gm, Bashir, Sajid, Yuk, Soon Hong, Bukhari, Syed Nasir Abbas

“…Polysaccharides are being extensively employed for the synthesis of silver nanoparticles (Ag NPs) having diverse morphology and applications. Herein, we…”
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Design, synthesis and antitrypanosomal activity of heteroaryl-based 1,2,4-triazole and 1,3,4-oxadiazole derivatives by Shaykoon, Montaser Sh, Marzouk, Adel A., Soltan, Osama M., Wanas, Amira S., Radwan, Mohamed M., Gouda, Ahmed M., Youssif, Bahaa G.M., Abdel-Aziz, Mohamed

“…[Display omitted] •Two series of 1,2,4-triazole and 1,3,4-oxadiazole derivatives were designed and synthesized.•3a-b and 4a-b showed higher antitrypanosomal…”
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Utilization of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinone as a cap moiety in design of novel histone deacetylase inhibitors by Mohamed, Mamdouh F.A., Youssif, Bahaa G.M., Shaykoon, Montaser Sh. A., Abdelrahman, Mostafa H., Elsadek, Bakheet E.M., Aboraia, Ahmed S., Abuo-Rahma, Gamal El-Din A.

“…[Display omitted] •12 novel compounds contain Tetrahydrobenzo[4,5]Thieno[2,3-d]pyrimidinone as a novel cap group, attached to ZBG via aliphatic, aralkyl or…”
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Novel 1,2,4-oxadiazole/pyrrolidine hybrids as DNA gyrase and topoisomerase IV inhibitors with potential antibacterial activity by Frejat, Firas Obaid Arhema, Cao, Yaquan, Zhai, Hongjin, Abdel-Aziz, Salah A., Gomaa, Hesham A.M., Youssif, Bahaa G.M., Wu, Chunli

“…DNA gyrase is a promising target for antibacterial agents. Several classes of small-molecule inhibitors have been discovered in recent decades, but none of…”
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Design, Synthesis and Antiproliferative Evaluation of Novel 1,2,4-Triazole/Schiff Base Hybrids with EGFR and B-RAF Inhibitory Activities by El-Sherief, Hany A M, Youssif, Bahaa G M, Abdelazeem, Ahmed H, Abdel-Aziz, Mohamed, Abdel-Rahman, Hamdy M

“…1,2,4-triazoles possess a broad spectrum of biological activities such as analgesic, antimicrobial, antitubercular, anti-inflammatory and antineoplastic…”
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Design, synthesis, crystal structures and biological evaluation of some 1,3-thiazolidin-4-ones as dual CDK2/EGFR potent inhibitors with potential apoptotic antiproliferative effects by Tawfeek, Hendawy N., Hassan, Alaa A., Bräse, S., Nieger, M., Mostafa, Yaser A., Gomaa, Hesham A.M., Youssif, Bahaa G.M., El-Shreef, Essmat M.

“…[Display omitted] •A series of thiazolidine-4-one derivatives as dual EGFR/CDK2 inhibitors has been developed.•Compounds 5d, 5e, and 5f were the most active…”
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Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety by Al-Sanea, Mohammad M, Gotina, Lizaveta, Mohamed, Mamdouh Fa, Grace Thomas Parambi, Della, Gomaa, Hesham A M, Mathew, Bijo, Youssif, Bahaa G M, Alharbi, Khalid Saad, Elsayed, Zainab M, Abdelgawad, Mohamed A, Eldehna, Wagdy M

“…Histone deacetylases (HDACs) represent one of the most validated cancer targets. The inhibition of HDACs has been proven to be a successful strategy for the…”
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Design and synthesis of novel quinoline/chalcone/1,2,4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases by Mohassab, Aliaa M., Hassan, Heba A., Abdelhamid, Dalia, Gouda, Ahmed M., Youssif, Bahaa G.M., Tateishi, Hiroshi, Fujita, Mikako, Otsuka, Masami, Abdel-Aziz, Mohamed

“…[Display omitted] •A series of quinoline/chalcone/1,2,4-triazole hybrids was synthesized and tested by NCI for their anticancer activity.•7b, 7d, 9b, and 9d…”
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Globally Approved EGFR Inhibitors: Insights into Their Syntheses, Target Kinases, Biological Activities, Receptor Interactions, and Metabolism by Abourehab, Mohammed A S, Alqahtani, Alaa M, Youssif, Bahaa G M, Gouda, Ahmed M

“…Targeting the EGFR with small-molecule inhibitors is a confirmed valid strategy in cancer therapy. Since the FDA approval of the first EGFR-TKI, erlotinib,…”
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Synthesis, anticancer activity and molecular modeling studies of 1,2,4-triazole derivatives as EGFR inhibitors by El-Sherief, Hany A.M., Youssif, Bahaa G.M., Abbas Bukhari, Syed Nasir, Abdelazeem, Ahmed H., Abdel-Aziz, Mohamed, Abdel-Rahman, Hamdy M.

“…A series of novel compounds carrying 1,2,4-triazole scaffold were prepared and evaluated for their antiproliferative activities against NCI 60 cell line…”
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Design, synthesis, and antiproliferative properties of new 1,2,3-triazole-carboximidamide derivatives as dual EGFR/VEGFR-2 inhibitors by Mahmoud, Mohamed A., Mohammed, Anber F., Salem, Ola I.A., Rabea, Safwat M., Youssif, Bahaa G.M.

“…•A series of 1,2,3-triazole-carboximidamide derivatives was designed and synthesised.•The new compounds were evaluated as antiproliferative agent targeting…”
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Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-Ib/I]indol-3-one Derivatives as Potent Inhibitors of EGFR[sup.T790M]/BRAF[sup.V600E] Pathways by Al-Wahaibi, Lamya H, Mohammed, Anber F, Abdelrahman, Mostafa H, Trembleau, Laurent, Youssif, Bahaa G. M

“…Mutant EGFR/BRAF pathways are thought to be crucial targets for the development of anticancer drugs since they are over-activated in several malignancies. We…”
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New quinoline/1,2,4-triazole hybrids as dual inhibitors of COX-2/5-LOX and inflammatory cytokines: Design, synthesis, and docking study by Mohassab, Aliaa M., Hassan, Heba A., Abdelhamid, Dalia, Gouda, Ahmed M., Gomaa, Hesham A.M., Youssif, Bahaa G.M., Radwan, Mohamed O., Fujita, Mikako, Otsuka, Masami, Abdel-Aziz, Mohamed

“…•Novel quinoline/1,2,4-triazole hybrids 6a-i and 7a-j as anti-inflammatory agents has been designed and synthesized.•Compounds 6e, 6i, and 7e showed potent…”
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Novel piperine-carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway by Al-Wahaibi, Lamya H., Mahmoud, Mohamed A., Mostafa, Yaser A., Raslan, Ali E., Youssif, Bahaa G. M.

“…A new series of piperine-carboximidamide hybrids VIa-k was developed as a new cytotoxic agent targeting EGFR, BRAF, and CDK2. The antiproliferative effect…”
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