Search Results - "Youssif, Bahaa G. M."

2-Nitroimidazole-Tricarbocyanine Conjugate as a Near-Infrared Fluorescent Probe for in Vivo Imaging of Tumor Hypoxia by Okuda, Kensuke, Okabe, Yasuyuki, Kadonosono, Tetsuya, Ueno, Takahiro, Youssif, Bahaa G. M, Kizaka-Kondoh, Shinae, Nagasawa, Hideko

“…We developed a novel near-infrared (NIR) fluorescent probe, GPU-167, for in vivo imaging of tumor hypoxia. GPU-167 comprises a tricarbocyanine dye as an NIR…”
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New 1,2,3-Triazole/1,2,4-triazole Hybrids as Aromatase Inhibitors: Design, Synthesis, and Apoptotic Antiproliferative Activity by Maghraby, Mohamed T-E, Mazyad Almutairi, Tahani, Bräse, Stefan, Salem, Ola I. A, Youssif, Bahaa G. M, Sheha, Mahmoud M

“…A novel series of 1,2,3-triazole/1,2,4-triazole hybrids 5a, 5b, and 6a–i was designed and synthesized as antiproliferative agents targeting aromatase enzymes…”
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Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors by Al-Wahaibi, Lamya H, Mostafa, Yaser A, Abdelrahman, Mostafa H, El-Bahrawy, Ali H, Trembleau, Laurent, Youssif, Bahaa G. M

“…The apoptotic antiproliferative actions of our previously reported CB1 allosteric modulators 5-chlorobenzofuran-2-carboxamide derivatives VIIa–j prompted us to…”
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Benzimidazole-Based Derivatives as Apoptotic Antiproliferative Agents: Design, Synthesis, Docking, and Mechanistic Studies by Youssif, Bahaa G M, Morcoss, Martha M, Bräse, Stefan, Abdel-Aziz, Mohamed, Abdel-Rahman, Hamdy M, Abou El-Ella, Dalal A, Abdelhafez, El Shimaa M N

“…A new class of benzimidazole-based derivatives ( - , , and ) with potential dual inhibition of EGFR and BRAF has been developed. The newly synthesized…”
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Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents by Al-Wahaibi, Lamya H, Mohammed, Anber F, Abdelrahman, Mostafa H, Trembleau, Laurent, Youssif, Bahaa G M

“…A small set of indole-based derivatives, and - , was designed and synthesized. Compounds - demonstrated promising antiproliferative activity, with GI values…”
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New Pyrazole/Pyrimidine-Based Scaffolds as Inhibitors of Heat Shock Protein 90 Endowed with Apoptotic Anti-Breast Cancer Activity by Al-Wahaibi, Lamya H, Elbastawesy, Mohammed A I, Abodya, Nader E, Youssif, Bahaa G M, Bräse, Stefan, Shabaan, Sara N, Sayed, Galal H, Anwer, Kurls E

“…: Supported by a comparative study between conventional, grinding, and microwave techniques, a mild and versatile method based on the [1 + 3] cycloaddition of…”
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Chalcone/1,3,4-Oxadiazole/Benzimidazole hybrids as novel anti-proliferative agents inducing apoptosis and inhibiting EGFR & BRAFV600E by Hagar, Fatma Fouad, Abbas, Samar H., Gomaa, Hesham A. M., Youssif, Bahaa G. M., Sayed, Ahmed M., Abdelhamid, Dalia, Abdel-Aziz, Mohamed

“…Introduction One of the most robust global challenges and difficulties in the 21st century is cancer. Treating cancer is a goal which continues to motivate…”
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Globally Approved EGFR Inhibitors: Insights into Their Syntheses, Target Kinases, Biological Activities, Receptor Interactions, and Metabolism by Abourehab, Mohammed A S, Alqahtani, Alaa M, Youssif, Bahaa G M, Gouda, Ahmed M

“…Targeting the EGFR with small-molecule inhibitors is a confirmed valid strategy in cancer therapy. Since the FDA approval of the first EGFR-TKI, erlotinib,…”
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Novel piperine-carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway by Al-Wahaibi, Lamya H., Mahmoud, Mohamed A., Mostafa, Yaser A., Raslan, Ali E., Youssif, Bahaa G. M.

“…A new series of piperine-carboximidamide hybrids VIa-k was developed as a new cytotoxic agent targeting EGFR, BRAF, and CDK2. The antiproliferative effect…”
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Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFRT790M/BRAFV600E Pathways by Al-Wahaibi, Lamya H., Mohammed, Anber F., Abdelrahman, Mostafa H., Trembleau, Laurent, Youssif, Bahaa G. M.

“…Mutant EGFR/BRAF pathways are thought to be crucial targets for the development of anticancer drugs since they are over-activated in several malignancies. We…”
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Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors by Mahmoud, Mohamed A, Mohammed, Anber F, Salem, Ola I A, Almutairi, Tahani Mazyad, Bräse, Stefan, Youssif, Bahaa G M

“…A novel series of 1,2,3-triazole/1,2,4-oxadiazole hybrids ( - ) was developed as dual inhibitors of EGFR/VEGFR-2. Compounds - were evaluated as…”
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Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl)quinolin-2(1H)-ones as Multi-Target Inhibitors by El-Sheref, Essmat M., Bräse, Stefan, Tawfeek, Hendawy N., Alasmary, Fatmah Ali, Youssif, Bahaa G. M.

“…The reaction of 4-azido-quinolin-2(1H)-ones 1a–e with the active methylene compounds pentane-2,4-dione (2a), 1,3-diphenylpropane-1,3-dione (2b), and K2CO3 was…”
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Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAFV600E Inhibitory Pathways by Al-Wahaibi, Lamya H., Abou-Zied, Hesham A., Hisham, Mohamed, Beshr, Eman A. M., Youssif, Bahaa G. M., Bräse, Stefan, Hayallah, Alaa M., Abdel-Aziz, Mohamed

“…A series of novel 3-cyanopyridone/pyrazoline hybrids (21–30) exhibiting dual inhibition against EGFR and BRAFV600E has been developed. The synthesized target…”
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Editorial: Pharmaceutical insights into the triazoles: Recent advances by Deng, Xianqing, Sun, Haopeng, Youssif, Bahaa G M

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Synthesis and Antiproliferative Potential of Thiazole and 4-Thiazolidinone Containing Motifs as Dual Inhibitors of EGFR and BRAFV600E by Hassan, Alaa A., Mohamed, Nasr K., Aly, Ashraf A., Ramadan, Mohamed, Gomaa, Hesham A. M., Abdel-Aziz, Ahmed T., Youssif, Bahaa G. M., Bräse, Stefan, Fuhr, Olaf

“…Thiazole and thiazolidinone recur in a wide range of biologically active compounds that reach different targets within the context of tumors and represent a…”
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Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitors by Al-Wahaibi, Lamya H., Mohammed, Anber F., Abdel Rahman, Fatema El-Zahraa S., Abdelrahman, Mostafa H., Gu, Xuyuan, Trembleau, Laurent, Youssif, Bahaa G. M.

“…A new series of indole-2-carboxamides 5a-g, 6a-f and pyrido[3,4-b]indol-1-ones 7a and 7b have been developed as new antiproliferative agents that target both…”
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Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Tri-Aryl Imidazole-Benzene Sulfonamide Hybrids as Promising Selective Carbonic Anhydrase IX and XII Inhibitors by Al-Wahaibi, Lamya H., Youssif, Bahaa G. M., Taher, Ehab S., Abdelazeem, Ahmed H., Abdelhamid, Antar A., Marzouk, Adel A.

“…A novel series of tri-aryl imidazole derivatives 5a–n carrying benzene sulfonamide moiety has been designed for their selective inhibitory against hCA IX and…”
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Structure-based design, synthesis, and biological evaluation of novel piperine-resveratrol hybrids as antiproliferative agents targeting SIRT-2 by Tantawy, Ahmed H, Meng, Xiang-Gao, Marzouk, Adel A, Fouad, Ali, Abdelazeem, Ahmed H, Youssif, Bahaa G. M, Jiang, Hong, Wang, Man-Qun

“…A series of novel piperine-resveratrol hybrids 5a-h was designed, synthesized, and structurally elucidated by IR, and 1 H, 13 C, and 19 F NMR…”
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Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAFV600E Inhibitors by Al-Wahaibi, Lamya H., Abou-Zied, Hesham A., Beshr, Eman A. M., Youssif, Bahaa G. M., Hayallah, Alaa M., Abdel-Aziz, Mohamed

“…Some new Bis-pyrazoline hybrids 8–17 with dual EGFR and BRAFV600E inhibitors have been developed. The target compounds were synthesized and tested in vitro…”
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Design, synthesis, docking and mechanistic studies of new thiazolyl/thiazolidinylpyrimidine-2,4-dione antiproliferative agents by Aly, Ashraf A., Alshammari, Mohammed B., Ahmad, Akil, A. M. Gomaa, Hesham, G. M. Youssif, Bahaa, Bräse, Stefan, A. A. Ibrahim, Mahmoud, Mohamed, Asmaa H.

“…In this article, we display on the synthesis and biological evaluation of a new series of thiazolylpyrimidine 3a-l and thiazolidinylpyrimidine derivatives…”
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