Search Results - "Youssefyeh, R. D."

Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides by Youssefyeh, R. D, Campbell, H. F, Klein, S, Airey, J. E, Darkes, P, Powers, M, Schnapper, M, Neuenschwander, K, Fitzpatrick, L. R

“…This report describes the development of novel benzamides which are orally active, highly potent, specific antagonists of 5-HT3 receptors. Described in this…”
Get full text

RG 12915: a potent 5-hydroxytryptamine-3 antagonist that is an orally effective inhibitor of cytotoxic drug-induced emesis in the ferret and dog by Fitzpatrick, L R, Lambert, R M, Pendley, C E, Martin, G E, Bostwick, J S, Gessner, G W, Airey, J E, Youssefyeh, R D, Pendleton, R G, Decktor, D L

“…RG 12915 [4-[N-(1-azabicyclo[2.2.2.]octan-3-(S)-yl)]2-chloro-cis 5a-(S)-9a-(S)-5a,6,7,8,9,9a-hexahydrobenzofurancarboxamide hydrochloride] is a potent and…”
Get more information

Characterization of the bisphosphonate recognition site on hydroxyapatite using radioligand binding techniques with [14C]citric acid by JARVIS, M. F, BURNS, C. J, PAULS, H. W, ASSAL, A, KIM, J. S, CHENEY, D. L, YOUSSEFYEH, R. D

“…The present studies characterize the binding of [14C]citric acid to synthetic hydroxyapatite (HA) crystals. [14C]Citric acid specifically bound to HA and was…”
Get full text

Structure and absolute configuration of a high affinity 5-HT3 receptor antagonist, (5aS,9aS)-N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-2-chloro- 5a,6,7,8,9,9a-hexahydro-4-dibenzofurancarboxamide hydrochloride by Ammon, H L, Youssefyeh, R D, Airey, J E, Studt, W L, Campbell, H F, Powers, M R, Golec, F A

“…The absolute configuration was established as (S,S,S) by the R-factor test and by careful measurement of 197 enantiomorph-sensitive Friedel pairs of…”
Get more information

Pyrido[3',2':4,5]thieno[3,2-d]-N-triazines: a new series of orally active antiallergic agents by Youssefyeh, Raymond D, Brown, Richard E, Wilson, Jeffrey, Shah, Uresh, Jones, Howard, Loev, Bernard, Khandwala, Atul, Leibowitz, Mitchell J, Sonnino-Goldman, Paula

“…A new series of orally active mediator release inhibitors, pyrido[3',2':4,5]thieno[3,2-d]-N-triazines, was synthesized and evaluated for antiallergic activity…”
Get full text

A New Synthesis of the Hydrophenanthrene Nucleus by Wenkert, Ernest, Youssefyeh, R. D, Lewis, Ronald G

Get full text

Development of high-affinity 5-HT3 receptor antagonists. 2. Two novel tricyclic benzamides by Youssefyeh, Raymond D, Campbell, H. F, Airey, J. E, Klein, S, Schnapper, M, Powers, M, Woodward, R, Rodriguez, W, Golec, S

“…Two new classes of potent 5-HT3 agents have been developed and examined as inhibitors of cytotoxic drug induced emesis in the ferret and dog. The absolute…”
Get full text

The Ozonolysis Reaction. A Working Hypothesis by Story, Paul R, Murray, R. W, Youssefyeh, R. D

Get full text

An Unequivocal Ozonide Stereoisomer Assignment by Murray, R. W, Youssefyeh, R. D, Story, Paul R

Get full text

New results in the total synthesis of 19-norsteroids by Saucy, G, Banner, B, Borer, R, Cohen, N, Eichel, W, Kwoh, S, Parrish, D R, Rosenberger, M, Youssefyeh, R D

Get more information

Alkali-induced Reactions of 1-Methyl-1-dichloromethyl-2(1H)-naphthalenone and Related Compounds by Dodson, R. M, Lewis, John R, Webb, William P, Wenkert, Ernest, Youssefyeh, R. D

Get full text

Angiotensin-converting enzyme inhibitors. New orally active antihypertensive (mercaptoalkanoyl)- and [(acylthio)alkanoyl]glycine derivatives by Suh, John T, Skiles, Jerry W, Williams, Bruce E, Youssefyeh, Raymond D, Jones, Howard, Loev, Bernard, Neiss, Edward S, Schwab, Alfred, Mann, William S

“…A variety of N-substituted (mercaptoalkanoyl)- and [(acylthio)alkanoyl]glycine derivatives was synthesized and their ability in inhibiting the activity of…”
Get full text

Photocyclodehydration of 6-o-biphenyloxy-1,3-dimethyluracil by Youssefyeh, R. D, Weisz, M

Get full text

Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 1. Initial structure-activity relationships by Youssefyeh, Raymond D, Magnien, Ernest, Lee, Thomas D. Y, Chan, Wan Kit, Lin, Clara J, Galemmo, Robert A, Johnson, William H, Tan, Jenny, Campbell, Henry F

“…This series of reports describes the development of orally active, highly potent, specific antagonists of the peptidoleukotrienes containing a…”
Get full text

Evidence against an Exclusive Zwitterion Intermediate in Ozonide Formation by Murray, R. W, Youssefyeh, R. D, Story, Paul R

Get full text

Antiallergic activity profile in vitro of RHC 2963 and related compounds by Khandwala, A, Van Inwegen, R, Coutts, S, Dally-Meade, V, Youssefyeh, R D

“…RHC 2963 (7-methyl-pyrido (3',2':4,5)-thieno (3,2-d)-1,2,3 triazine-4(3H)-one and 20 related compounds have been investigated for their antiallergic activities…”
Get more information

Evidence for a new mechanism of ozonolysis by Story, Paul R, Bishop, Clyde E, Burgess, John R, Murray, R. W, Youssefyeh, R. D

Get full text

Reactions of 4,5-diaminouracils by Youssefyeh, R. D., Kalmus, A.

“…Reactions of 4,5‐diaminopyrimidines with various phthalic derivatives, depending on the conditions employed, led to pyrimidines with a 5‐N‐substituted…”
Get full text

Reaction of 6-amino-1,3-dimethyl-5-nitrosouracil with thiols by Youssefyeh, R D

Get more information

Reaction of 4,5-diaminopyrimidines with 2,5-hexanedione by Youssefyeh, R. D., Kalmus, A.

“…Reaction of 2,5‐hexanedione with various 4,5‐diaminopyrimidines was found to lead to the formation of 5‐(N‐pyrryl)‐4‐aminopyrimidines. Structural assignments…”
Get full text