Search Results - "Youssef Ramli"

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review by Karrouchi, Khalid, Radi, Smaail, Ramli, Youssef, Taoufik, Jamal, Mabkhot, Yahia N, Al-Aizari, Faiz A, Ansar, M'hammed

“…Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The…”
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New Pyrazole-Hydrazone Derivatives: X-ray Analysis, Molecular Structure Investigation via Density Functional Theory (DFT) and Their High In-Situ Catecholase Activity by Karrouchi, Khalid, Yousfi, El Bekkaye, Sebbar, Nada Kheira, Ramli, Youssef, Taoufik, Jamal, Ouzidan, Younes, Ansar, M'hammed, Mabkhot, Yahia N, Ghabbour, Hazem A, Radi, Smaail

“…The development of low-cost catalytic systems that mimic the activity of tyrosinase enzymes (Catechol oxidase) is of great promise for future biochemistry…”
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Synthesis and crystal structure of 3-octyl-5,5-diphenylimidazolidine-2,4-dione, C23H28N2O2 by Guerrab, Walid, Mague, Joel T., Ramli, Youssef

“…, orthorhombic, (no. 61), = 10.713(2) Å, = 15.689(3) Å, = 24.485(5) Å, = 4115.2(14) Å , = 8, ) = 0.0581, ) = 0.1734, = 120(2) K…”
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A possible potential COVID-19 drug candidate: Diethyl 2-(2-(2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetyl)hydrazono)malonate: Docking of disordered independent molecules of a novel crystal structure, HSA/DFT/XRD and cytotoxicity by Missioui, Mohcine, Said, Musa A., Demirtaş, Güneş, Mague, Joel T., Al-Sulami, Ahlam, Al-Kaff, Nadia S., Ramli, Youssef

“…This study reports the synthesis, characterization and importance of a novel diethyl 2-(2-(2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetyl)hydrazono)malonate…”
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Synthesis and crystal structure of (E)-1-benzyl-3-(4-methoxystyryl)quinoxalin-2(1H)-one, C24H20N2O2 by Missioui, Mohcine, Essassi, El Mokhtar, Mague, Joel T., Ramli, Youssef

“…, monoclinic, (no. 14), = 11.1713(3) Å, = 17.7718(5) Å, = 10.9852(3) Å, = 118.990(1)°, = 1907.67(9) Å , = 4, ) = 0.0538, ) = 0.1582, = 296(2) K…”
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Synthesis and crystal structure of 2-azido-N-phenylacetamide, C8H8N4O by Guerrab, Walid, Missioui, Mohcine, Zaoui, Younes, Mague, Joel T., Ramli, Youssef

“…O, orthorhombic, (no. 19),  = 5.8085(13) Å,  = 16.533(4) Å,  = 18.171(4) Å,  = 1745.0(7) Å ,  = 8, ) = 0.0399, ) = 0.1078, T = 296(2) K…”
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Synthesis and crystal structure of 2-azido-N-(4-nitrophenyl)acetamide, C8H7N5O3 by Missioui, Mohcine, Guerrab, Walid, Mague, Joel T., Ramli, Youssef

“…, monoclinic, (no. 14), = 5.0340(2) Å, = 21.1023(9) Å, = 9.2880(4) Å, = 94.909(1)°, = 983.04(7) Å , = 4, ) = 0.0470, ) = 0.1496, = 298(2) K…”
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Greener pastures in evaluating antidiabetic drug for a quinoxaline Derivative: Synthesis, Characterization, Molecular Docking, in vitro and HSA/DFT/XRD studies by Missioui, Mohcine, Mortada, Salma, Guerrab, Walid, Demirtaş, Güneş, Mague, Joel T., Ansar, M'hammed, El Abbes Faouzi, My, Essassi, E.M., Mehdar, Yassin T.H., Aljohani, Faizah S., Said, Musa A., Ramli, Youssef

“…The physicochemical, pharmacokinetic and toxicological properties of MOQTA have been evaluated. [Display omitted] •A new quinoxaline containing triazole MOQTA…”
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Synthesis and crystal structure of 1-octyl-3-phenylquinoxalin-2(1H)-one, C22H26N2O by Abad, Nadeem, Ferfra, Souad, Essassi, El Mokhtar, Mague, Joel T., Ramli, Youssef

“…O, monoclinic, 2/ (no. 15),  = 47.4887(9) Å,  = 5.0220(1) Å,  = 16.4551(3) Å,  = 108.993(1)°,  = 3710.70(12) Å ,  = 8, ) = 0.0345, ) = 0.0935, T = 150(2) K…”
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Synthesis, crystal structure and Hirshfeld surface analysis of 2-{4-[(2-chlorophenyl)methyl]-3-methyl-6-oxopyridazin-1-yl}- N -phenylacetamide by Assila, Hamza, Zaoui, Younes, Kalonji Mubengayi, Camille, Guerrab, Walid, Alsubari, Abdulsalam, Mague, Joel T., Ramli, Youssef, Ansar, Mhammed

“…In the title molecule, C 20 H 18 ClN 3 O 2 , the 2-chlorophenyl group is disordered to a small extent [occupancies 0.875 (2)/0.125 (2)]. The phenylacetamide…”
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Noncovalent interactions between quinoxalines and protoporphyrinogen oxidase (PPO): a computational case study for herbicidal applications by Hajji, Melek, Abad, Nadeem, Dallel, Meriem, Al-Ghulikah, Hanan, Hafi, Mohamed El, Guerfel, Taha, Mague, Joel T., Essassi, El Mokhtar, Ramli, Youssef

“…Quinoxaline-based compounds show promising inhibition of protoporphyrinogen oxidase (PPO), a key enzyme in chlorophyll production and a prime target for…”
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Synthesis, crystal structure and Hirshfeld surface analysis of 1-[(1-octyl-1 H -1,2,3-triazol-4-yl)methyl]-3-phenyl-1,2-dihydroquinoxalin-2(1 H )-one by Abad, Nadeem, Mague, Joel T., Kalonji Mubengayi, Camille, Alsubari, Abdulsalam, Essassi, El Mokhtar, Ramli, Youssef

“…In the title molecule, C 25 H 29 N 5 O, the dihydroquinoxaline unit is not quite planar (r.m.s. deviation = 0.030 Å) as there is a dihedral angle of 2.69 (3)°…”
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Crystal structure and Hirshfeld surface analysis of 3-phenyl-1-{3-[(3-phenylquinoxalin-2-yl)oxy]propyl}-1,2-dihydroquinoxalin-2-one by Abad, Nadeem, Mague, Joel T., Alsubari, Abdulsalam, Essassi, El Mokhtar, Alzahrani, Abdullah Yahya Abdullah, Ramli, Youssef

“…In the title compound, C 31 H 24 N 4 O 2 , the quinoxaline units are distinctly non-planar and twisted end-to-end. In the crystal, C—H...O and C—H...N hydrogen…”
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Unlocking Benzosampangine’s Potential: A Computational Approach to Investigating, Its Role as a PD-L1 Inhibitor in Tumor Immune Evasion via Molecular Docking, Dynamic Simulation, and ADMET Profiling by Ouchaoui, Abderrahim Ait, Hadad, Salah Eddine El, Aherkou, Marouane, Fadoua, Elkamili, Mouad, Mkamel, Ramli, Youssef, Kettani, Anass, Bourais, Ilhame

“…The interaction between programmed cell death protein 1 (PD-1) and its ligand PD-L1 plays a crucial role in tumor immune evasion, presenting a critical target…”
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Synthesis, crystal structure and Hirshfeld surface analysis of 1-[3-(2-oxo-3-phenyl-1,2-dihydroquinoxalin-1-yl)propyl]-3-phenyl-1,2-dihydroquinoxalin-2-one by Abad, Nadeem, Mague, Joel T., Alsubari, Abdulsalam, Essassi, El Mokhtar, Alzahrani, Abdullah Yahya Abdullah, Ramli, Youssef

“…In the title compound, C 31 H 24 N 4 O 2 , the dihydroquinoxaline units are both essentially planar with the dihedral angle between their mean planes being…”
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Synthesis, crystal structure and Hirshfeld surface analysis of 2-phenyl-3-(prop-2-yn-1-yloxy)quinoxaline by Abad, Nadeem, Mague, Joel T., Alsubari, Abdulsalam, Essassi, El Mokhtar, Pourayoubi, Mehrdad, Yahya Abdullah Alzahrani, Abdullah, Ramli, Youssef

“…In the title compound, C 17 H 12 N 2 O, the quinoxaline moiety shows deviations of 0.0288 (7) to −0.0370 (7) Å from the mean plane (r.m.s. deviation of fitted…”
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Crystal structure and Hirshfeld surface analysis of N -(2,6-di-methyl-phen-yl)-2-[3-hy-droxy-2-oxo-3-(2-oxoprop-yl)indolin-1-yl]acetamide by Nchioua, Intissar, Alsubari, Abdulsalam, Mague, Joel T, Ramli, Youssef

“…The cup-shaped conformation of the title mol-ecule, C H N O , is largely determined by an intra-molecular N-H⋯O hydrogen bond. In the crystal, double layers of…”
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Crystal structure and Hirshfeld surface analysis of 2-azido- N -(4-fluoro-phen-yl)acetamide by Missioui, Mohcine, Guerrab, Walid, Alsubari, Abdulsalam, Mague, Joel T, Ramli, Youssef

“…The asymmetric unit of the title compound, C H FN O, consists of two independent mol-ecules differing in the orientation of the azido group. Each mol-ecule…”
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Pharmacological Profile of Quinoxalinone by Essassi, El Mokhtar, Karrouchi, Khalid, Moussaif, Ahmed, Ramli, Youssef

“…Quinoxalinone and its derivatives are used in organic synthesis for building natural and designed synthetic compounds and they have been frequently utilized as…”
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Synthesis, crystal structure and Hirshfeld surface of ethyl 2-[2-(methyl-sulfan-yl)-5-oxo-4,4-diphenyl-4,5-di-hydro-1 H -imidazol-1-yl]acetate (thio-phenytoin derivative) by El Moutaouakil Ala Allah, Abderrazzak, Kariuki, Benson M, Alsubari, Abdulsalam, Al-Sulami, Ahlam I, Allehyani, Basmah H, Alsulami, Wafa O, Mague, Joel T, Ramli, Youssef

“…The di-hydro-imidazole ring in the title mol-ecule, C H N O S, is slightly distorted and the lone pair on the tri-coordinate nitro-gen atom is involved in…”
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