Search Results - "Youssef, Amal M."

Design, synthesis, anti-inflammatory evaluation, and molecular modelling of new coumarin-based analogs combined curcumin and other heterocycles as potential TNF-α production inhibitors via upregulating Nrf2/HO-1, downregulating AKT/mTOR signalling pathways and downregulating NF-κB in LPS induced macrophages by Ghany, Lina M A Abdel, Beshay, Botros Y, Youssef Moustafa, Amal M, Maghrabi, Ali Hassan Ahmed, Ali, Eman Hussain Khalifa, Saleem, Rasha Mohammed, Zaki, Islam, Ryad, Noha

“…Persistent inflammation contributes to various inflammatory conditions. Inflammation-related diseases may be treated by inhibiting pro-inflammatory mediators…”
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The protective effect of biochanin A against rotenone-induced neurotoxicity in mice involves enhancing of PI3K/Akt/mTOR signaling and beclin-1 production by El-Sherbeeny, Nagla A., Soliman, Nema, Youssef, Amal M., Abd El-Fadeal, Noha M., El-Abaseri, Taghrid B., Hashish, Abdullah A., Abdelbasset, Walid Kamal, El-Saber Batiha, Gaber, Zaitone, Sawsan A.

“…Rotenone is an insecticide that generates oxidative stress in the CNS and induces locomotor dysfunction and neurodegeneration in rodents. Biochanin A [BioA] is…”
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Protective effect of metformin on rat diabetic retinopathy involves suppression of toll-like receptor 4/nuclear factor-k B expression and glutamate excitotoxicity by Alomar, Suliman Y., M. Barakat, Bassant, Eldosoky, Mohamed, Atef, Hoda, Mohamed, Abdelaty Shawky, Elhawary, Reda, El-Shafey, Mohamed, Youssef, Amal M., Elkazaz, Amany Y., Gabr, Attia M., Elaskary, Abdelhakeem A., Salih, Mohamed A.K., Alolayan, Sultan Othman, Zaitone, Sawsan A.

“…•Rat diabetic retinopathy was associated was upregulated TLR4/NFκB expression.•Retinal glutamate and cytokine levels were elevated.•Metformin enhanced the…”
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Synthesis and Antitumor Activity of Doxycycline Polymeric Nanoparticles: Effect on Tumor Apoptosis in Solid Ehrlich Carcinoma by Gardouh, Ahmed R, Attia, Mohammed A, Enan, Eman T, Elbahaie, Alaaeldeen M, Fouad, Rania A, El-Shafey, Mohamed, Youssef, Amal M, Alomar, Suliman Y, Ali, Zinab Abd-Elhady, Zaitone, Sawsan A, Qushawy, Mona K E

“…The aim of this study was to prepare doxycycline polymeric nanoparticles (DOXY-PNPs) with hope to enhance its chemotherapeutic potential against solid Ehrlich…”
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Carbamazepine Alleviates Retinal and Optic Nerve Neural Degeneration in Diabetic Mice via Nerve Growth Factor-Induced PI3K/Akt/mTOR Activation by Elsherbiny, Nehal M, Abdel-Mottaleb, Yousra, Elkazaz, Amany Y, Atef, Hoda, Lashine, Rehab M, Youssef, Amal M, Ezzat, Wessam, El-Ghaiesh, Sabah H, Elshaer, Rabie E, El-Shafey, Mohamed, Zaitone, Sawsan A

“…Diabetic retinopathy causes loss of vision in adults at working-age. Few therapeutic options are available for treatment of diabetic retinopathy. Carbamazepine…”
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Anti-inflammatory drug approach: Synthesis and biological evaluation of novel pyrazolo[3,4-d]pyrimidine compounds by Atatreh, Noor, Youssef, Amal M., Ghattas, Mohammad A., Al Sorkhy, Mohammad, Alrawashdeh, Sara, Al-Harbi, Khaled B., El-Ashmawy, Ibrahim M., Almundarij, Tariq I., Abdelghani, Amani A., Abd-El-Aziz, Alaa S.

“…The present work describes the design and synthesis of novel series of ten pyrazolo[3,4-d]pyrazolo derivatives. Four compounds 3a, 3d, 4d and 4f were notable…”
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Evening Primrose Oil Ameliorates Hyperleptinemia and Reproductive Hormone Disturbances in Obese Female Rats: Impact on Estrus Cyclicity by Atteia, Hebatallah H, Alzahrani, Sharifa, El-Sherbeeny, Nagla A, Youssef, Amal M, Farag, Noha E, Mehanna, Eman T, Elhawary, Reda, Ibrahim, Gehan A, Elmistekawy, Amr, Zaitone, Sawsan A

“…Obesity is a public health burden disturbing all body functions and reproductive hormones. As obesity increases among females, there will be a rising challenge…”
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Synthesis of new quaternized chitosan Schiff bases and their N-alkyl derivatives as antimicrobial and anti-biofilm retardants in membrane technology by Youssef Moustafa, Amal M., Fawzy, Mona M., Kelany, Mahmoud S., Hassan, Yasser A., Elsharaawy, Reda F.M., Mustafa, Fatma H.A.

“…New quaternized salicylidene chitosan Schiff bases (QSCSBs) and their N-octyl derivatives (OQCs) have been synthesized and characterized, aiming to develop…”
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Synthesis and anticancer activity of novel benzimidazole and benzothiazole derivatives against HepG2 liver cancer cells by Youssef, Amal M, Malki, Ahmed, Badr, Mona H, Elbayaa, Rasha Y, Sultan, Ahmed S

“…Most of cancer chemotherapeutics and chemopreventives exert their effects by triggering apoptotic cell death. In this study, novel benzimidazole and…”
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Synthesis and Cytotoxicity Against Human Breast Carcinoma Cell Evaluation of Some New 3,4-Disubstituted Coumarin Derivatives by Radwan, Eman M., Elsayed, Elsherbiny H., El-Moneim, Mohamed Abd, Youssef Moustafa, Amal M.

“…A novel series of 3,4-disubstitutued coumarin derivatives have been synthesized by the reaction of ethyl coumarin-3-carboxylate with pyrazole-3,5-dione and…”
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Design, synthesis and biological screening of some pyridinylpyrazole and pyridinylisoxazole derivatives as potential anti-inflammatory, analgesic, antipyretic and antimicrobial agents by El-Hawash, Soad A M, Soliman, Raafat, Youssef, Amal M, Ragab, Hanan M A, Elzahhar, Perihan A S, El-Ashmawey, Ibrahim M, Abdel Wahab, Abeer E, Shaat, Iman A

“…A series of substituted pyridinylpyrazole (or isoxazole) derivatives were synthesized and evaluated for their anti-inflammatory (AI) activity using…”
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Pyrazole compound 2-MBAPA as a novel inhibitor of microglial activation and neurotoxicity in vitro and in vivo by Hashioka, Sadayuki, McLarnon, James G, Ryu, Jae K, Youssef, Amal M, Abd-El-Aziz, Alaa S, Neeland, Edward G, Klegeris, Andis

“…Pyrazole derivatives are well documented to possess anti-inflammatory activity but their effects on microglial activation are unknown. We determined the…”
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Design, synthesis and antimicrobial evaluation of methyl pyridyl-2,4- dioxobutanoates and some new derived ring systems by Elzahhar, Perihan A S, Soliman, Raafat, El-Hawash, Soad A M, Ragab, Hanan M A, Youssef, Amal M, Wahab, Abeer E Abdel

“…This work describes the synthesis of new series of compounds derived from methyl pyridyl- 2,4-dioxobutanoates that contain pyridine ring attached to…”
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Corrigendum to “Inhibitory effect of valproate sodium on pain behavior in diabetic mice involves suppression of spinal histone deacetylase 1 and inflammatory mediators” [Int. Immunopharmacol. 70 (2019) 16–27] by Elsherbiny, Nehal M., Ahmed, Eman, Abdel Kader, Ghada, Abdel-mottaleb, Yousra, ElSayed, Mohamed H., Youssef, Amal M., Zaitone, Sawsan A.

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Effects of Quercetin and Coenzyme Q10 on Biochemical, Molecular, and Morphological Parameters of Skeletal Muscle in Trained Diabetic Rats by Youssef, Amal M, Mohamed, Dalia A, Hussein, Samia, Abdullah, Doaa M, Abdelrahman, Shaimaa A

“…Diabetes mellitus (DM) affects the musculoskeletal system through its metabolic perturbations. Exercise modulates blood sugar levels and increases the body's…”
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Inhibitory effect of valproate sodium on pain behavior in diabetic mice involves suppression of spinal histone deacetylase 1 and inflammatory mediators by Elsherbiny, Nehal M., Ahmed, Eman, Kader, Ghada Abdel, Abdel-mottaleb, Yousra, ElSayed, Mohamed H., Youssef, Amal M., Zaitone, Sawsan A.

“…Anti-epileptic medications are included in the international guidelines for managing neuropathic pain. Valproate sodium (VPS) was recently described as “the…”
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Methanolic extracts of a selected Egyptian Vicia faba cultivar mitigate the oxidative/inflammatory burden and afford neuroprotection in a mouse model of Parkinson’s disease by Abdel-Sattar, Essam, Mahrous, Engy A., Thabet, Mareena M., Elnaggar, Dina M. Yousry, Youssef, Amal M., Elhawary, Reda, Zaitone, Sawsan A., Celia Rodríguez-Pérez, Segura-Carretero, Antonio, Mekky, Reham Hassan

“…Vicia faba L. is a legume from the family Fabaceae. Ancient Egyptians consumed fava beans thousands of years ago and they are still one of the most popular…”
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Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents by Youssef, Amal M., Sydney White, M., Villanueva, Erika B., El-Ashmawy, Ibrahim M., Klegeris, Andis

“…A number of in vitro and in vivo assays were used to identify four novel pyrazolyl-2,4-thiazolidinediones ( 5a– c, 7b) as potential anti-inflammatory and…”
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Chemopreventive effect of α-hederin/carboplatin combination against experimental colon hyperplasia and impact on JNK signaling by Bahr, Hoda I., Ibrahiem, Afaf T., Gabr, Attia M., Elbahaie, Alaaeldeen M., Elmahdi, Hoda S., Soliman, Nema, Youssef, Amal M., El-Sherbiny, Mohamed, Zaitone, Sawsan A.

“…Colon cancer is the commonest cancer worldwide. α-Hederin is a monodesmosidic triterpenoid saponin possessing diverse pharmacological activities. The running…”
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Correction to: Methanolic extracts of a selected Egyptian Vicia faba cultivar mitigate the oxidative/inflammatory burden and afford neuroprotection in a mouse model of Parkinson's disease by Abdel-Sattar, Essam, Mahrous, Engy A., Thabet, Mareena M., Elnaggar, Dina M. Yousry, Youssef, Amal M., Elhawary, Reda, Zaitone, Sawsan A., Rodríguez-Pérez, Celia, Segura-Carretero, Antonio, Mekky, Reham Hassan

“…Addition of an affiliation to an author…”
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