A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses

A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses

A novel human coronavirus prompted considerable worry at the end of the year 2019. Now, it represents a significant global health and economic burden. The newly emerged coronavirus disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the primary reason for the COVID-...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Vol. 26; no. 21; p. 6455
Main Authors: Nassar, Aaya, Ibrahim, Ibrahim M., Amin, Fatma G., Magdy, Merna, Elgharib, Ahmed M., Azzam, Eman B., Nasser, Filopateer, Yousry, Kirllos, Shamkh, Israa M., Mahdy, Samah M., Elfiky, Abdo A.
Format: Journal Article
Language:English
Published: Basel MDPI AG 26-10-2021
MDPI
Subjects:
Amino acids
cell receptor
Coronaviruses
COVID-19
Enzymes
Epidemics
Fatalities
Genomes
Global health
human coronavirus
Middle East respiratory syndrome
Peptides
Proteins
Public health
Respiratory diseases
Review
SARS-CoV-2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
spike
Vaccines
viral entry
Viral infections
Viruses
Middle East
China
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Summary:A novel human coronavirus prompted considerable worry at the end of the year 2019. Now, it represents a significant global health and economic burden. The newly emerged coronavirus disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the primary reason for the COVID-19 global pandemic. According to recent global figures, COVID-19 has caused approximately 243.3 million illnesses and 4.9 million deaths. Several human cell receptors are involved in the virus identification of the host cells and entering them. Hence, understanding how the virus binds to host-cell receptors is crucial for developing antiviral treatments and vaccines. The current work aimed to determine the multiple host-cell receptors that bind with SARS-CoV-2 and other human coronaviruses for the purpose of cell entry. Extensive research is needed using neutralizing antibodies, natural chemicals, and therapeutic peptides to target those host-cell receptors in extremely susceptible individuals. More research is needed to map SARS-CoV-2 cell entry pathways in order to identify potential viral inhibitors.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26216455