Search Results - "Yousif, Obada"

Development of a novel medium throughput flow-cytometry based micro-neutralisation test for SARS-CoV-2 with applications in clinical vaccine trials and antibody screening by O'Reilly, Sophie, Kenny, Grace, Alrawahneh, Tamara, Francois, Nathan, Gu, Lili, Angeliadis, Matthew, de Masson d'Autume, Valentin, Garcia Leon, Alejandro, Feeney, Eoin R, Yousif, Obada, Cotter, Aoife, de Barra, Eoghan, Horgan, Mary, Mallon, Patrick W. G, Gautier, Virginie

“…Quantifying neutralising capacity of circulating SARS-COV-2 antibodies is critical in evaluating protective humoral immune responses generated…”
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Identification of Distinct Long COVID Clinical Phenotypes Through Cluster Analysis of Self-Reported Symptoms by Kenny, Grace, McCann, Kathleen, O’Brien, Conor, Savinelli, Stefano, Tinago, Willard, Yousif, Obada, Lambert, John S, O’Broin, Cathal, Feeney, Eoin R, De Barra, Eoghan, Doran, Peter, Mallon, Patrick W G

“…Abstract Background We aimed to describe the clinical presentation of individuals presenting with prolonged recovery from coronavirus disease 2019 (COVID-19),…”
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Impact of vaccination and variants of concern on long COVID clinical phenotypes by Kenny, Grace, McCann, Kathleen, O'Brien, Conor, O'Broin, Cathal, Tinago, Willard, Yousif, Obada, O'Gorman, Tessa, Cotter, Aoife G, Lambert, John S, Feeney, Eoin R, de Barra, Eoghan, Sadlier, Corinna, Landay, Alan, Doran, Peter, Savinelli, Stefano, Mallon, Patrick W. G, MacCann, Rachel, Garcia Leon, Alejandro, Miles, Sarah, Alalwan, Dana, Negi, Riya, Muldoon, Eavan, Sheehan, Gerard, McGinty, Tara, Green, Sandra, Leamy, Kelly, Kelly, Christine, de Barra, Eoin, McConkey, Samuel, Hurley, Killain, Sulaiman, Imran, Horgan, Mary, Eustace, Joseph, Bracken, Tommy, Whelan, Bryan, Low, Justin, McNicholas, Bairbre, Courtney, Garry, Gavin, Patrick

“…Abstract Background Defining patterns of symptoms in long COVID is necessary to advance therapies for this heterogeneous condition. Here we aimed to describe…”
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Dysregulated early transcriptional signatures linked to mast cell and interferon responses are implicated in COVID-19 severity by MacCann, Rachel, Leon, Alejandro Abner Garcia, Gonzalez, Gabriel, Carr, Michael J, Feeney, Eoin R, Yousif, Obada, Cotter, Aoife G, de Barra, Eoghan, Sadlier, Corinna, Doran, Peter, Mallon, Patrick W

“…Dysregulated immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are thought to underlie the progression of coronavirus…”
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Early inflammatory profiles predict maximal disease severity in COVID-19: An unsupervised cluster analysis by Kenny, Grace, Saini, Gurvin, Gaillard, Colette Marie, Negi, Riya, Alalwan, Dana, Garcia Leon, Alejandro, McCann, Kathleen, Tinago, Willard, Kelly, Christine, Cotter, Aoife G., de Barra, Eoghan, Horgan, Mary, Yousif, Obada, Gautier, Virginie, Landay, Alan, McAuley, Danny, Feeney, Eoin R., O'Kane, Cecilia, Mallon, Patrick WG

“…The inflammatory changes that underlie the heterogeneous presentations of COVID-19 remain incompletely understood. In this study we aimed to identify…”
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Associations between host microbiome and inflammation suggest role for host microbiome in driving COVID-19 disease severity by MacCann, Rachel, Ghosh, Tarini Shankar, Garcia Leon, Alejandro Abner, Li, Junhui, Negi, Riya, Gaillard, Colette, Saini, Gurvin, Tinago, Willard, Feeney, Eoin R., Yousif, Obada, Cotter, Aoife G., de Barra, Eoghan, Sadlier, Corinna, Doran, Peter, Landay, Alan, O'Toole, Paul W., Mallon, Patrick W.

“…Systemic inflammation and innate immune activation are associated with COVID-19 disease severity. Knowledge gaps remain in the relationships between…”
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Performance and validation of an adaptable multiplex assay for detection of serologic response to SARS-CoV-2 infection or vaccination by Kenny, Grace, Negi, Riya, O'Reilly, Sophie, Garcia-Leon, Alejandro, Alalwan, Dana, Gaillard, Colette Marie, Saini, Gurvin, Inzitari, Rosana, Feeney, Eoin R., Yousif, Obada, Cotter, Aoife G, de Barra, Eoghan, Sadlier, Corinna, Crispie, Fiona, Doran, Peter, Gautier, Virginie, Mallon, Patrick W.G.

“…Measurement of quantitative antibody responses are increasingly important in evaluating the immune response to infection and vaccination. In this study we…”
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Distinct receptor binding domain IgG thresholds predict protective host immunity across SARS-CoV-2 variants and time by Kenny, Grace, O’Reilly, Sophie, Wrigley Kelly, Neil, Negi, Riya, Gaillard, Colette, Alalwan, Dana, Saini, Gurvin, Alrawahneh, Tamara, Francois, Nathan, Angeliadis, Matthew, Garcia Leon, Alejandro Abner, Tinago, Willard, Feeney, Eoin R., Cotter, Aoife G., de Barra, Eoghan, Yousif, Obada, Horgan, Mary, Doran, Peter, Stemler, Jannik, Koehler, Philipp, Cox, Rebecca Jane, O’Shea, Donal, Olesen, Ole F., Landay, Alan, Hogan, Andrew E., Lelievre, Jean-Daniel, Gautier, Virginie, Cornely, Oliver A., Mallon, Patrick W. G.

“…SARS-CoV-2 neutralising antibodies provide protection against COVID-19. Evidence from early vaccine trials suggested binding antibody thresholds could serve as…”
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Retrospective national cohort study of pregnancy outcomes for women with type 1 and type 2 diabetes mellitus in Republic of Ireland by Newman, Christine, Egan, Aoife M., Ahern, Tomas, Al-Kiyumi, Maisa, Bacon, Siobhan, Bahaeldein, Elgelani, Balan, Gabriela, Brassill, Mary-Jane, Breslin, Emily, Brosnan, Elizabeth, Carmody, Louise, Clarke, Hilda, Coogan Kelly, Caroline, Culliney, Linda, Davern, Recie, Durkan, Maeve, Elhilo, Kalthoom, Cullen, Elizabeth, Fenlon, Mairead, Ferry, Pauline, Gabir, Ahmed, Guinan, Linda, Hanlon, Geraldine, Heffernan, Marie, Higgins, Tom, Hoashi, Shu, Kgosidialwa, Oratile, Khamis, Amjed, Kinsley, Brendan, Kirwan, Breda, James, Anne, Kyithar, Pyeh, Liew, Aaron, Malik, Ihtisham, Matthews, Linda, McGurk, Colm, McHugh, Cathy, Moloney, Yvonne, Murphy, Matt S, Murphy, Paula, Nagodra, Dina, Noctor, Eoin, Nolan, Marie, O'Connor, Aislong, O'Connor, Emily, O'Halloran, Domhnall, O'Mahoney, Linda, O'Shea, Triona, O'Sullivan, Eoin P., Peters, Moby, Roberts, Graham, Rooney, Hannorah, Sharma, Jayant, Smyth, Aoife, Synnott, Maria, Tarachand, Bheesham, Tighe, Marie, Todd, Marie, Towers, Michael, Tuthill, Antoinette, Mahmood, Wan, Yousif, Obada, Dunne, Fidelma P.

“…Report the outcomes of pregnant women with type 1 and type 2 diabetes and to identify modifiable and non-modifiable factors associated with poor outcomes…”
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1346. Genetic Variation at the Interferon λ Locus and Association with Clinical Outcome and Severity of COVID-19 by Alalwan, Dana, Negi, Riya, García-León, Alejandro, Saini, Gurvin, Gaillard, Colette Marie, Kenny, Grace, Savinelli, Stefano, Feeney, Eoin R, Cotter, Aoife, Carr, Michael, Gonzalez, Gabriel, Landay, Alan, de Barra, Eoghan, Yousif, Obada, Horgan, Mary, Mallon, Patrick

“…Abstract Background People with obesity are at increased risk of severe COVID-19, with host inflammation a key contributor. Interferon (IFN) lambda 4 (IFNλ4)…”
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1057. Development of a Flow Cytometry-Based Micro-Neutralisation Assay to Evaluate Humoral Immunity Against SARS-CoV-2 Variants of Concern in Vaccine Trials by O’Reilly, Sophie R, Kenny, Grace, Alrawahneh, Tamara, Francois, Nathan, Angeliadis, Matthew, de Masson d’Autume, Valentin, Garcia-Leon, Alejandro, Feeney, Eoin, Yousif, Obada, Cotter, Aoife, de Barra, Eoghan, Horgan, Mary, Mallon, Patrick, BCh, M B, Gautier, Virginie

“…Abstract Background Quantifying neutralising capacity of circulating SARS-COV-2 antibodies is critical in evaluating protective humoral immune responses…”
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77. Demonstration of stable clusters of symptoms in long COVID by Kenny, Grace, McCann, Kathleen, O'Brien, Conor, Savinelli, Stefano, O'Broin, Cathal, Tinago, Willard, Yousif, Obada, Lambert, John S, Feeney, Eoin, de Barra, Eoghan, Sadlier, Corinna, Landay, Alan, Doran, Peter, Mallon, Patrick W G

“…Abstract Background Long COVID is a heterogenous condition. We previously demonstrated distinct phenotypes of long COVID, but the impact of later waves caused…”
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312. Performance and validation of an adaptable multiplex assay for detection of serologic response to SARS-CoV-2 infection or vaccination by Kenny, Grace, O’Reilly, Sophie R, Negi, Riya, Garcia-Leon, Alejandro, Alalwan, Dana, Gaillard, Colette Marie, Saini, Gurvin, Inzitari, Rosanna, Feeney, Eoin, Yousif, Obada, Cotter, Aoife, de Barra, Eoghan, Sadlier, Corinna, Crispie, Fiona, Doran, Peter, Gautier, Virginie, Mallon, Patrick, BCh, M B

“…Abstract Background A wide array of assays to detect the serologic response to SARS-CoV-2 have been developed since the emergence of the pandemic. The majority…”
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2356. Close correlation of RBD with Live Viral Neutralising Capacity Across Variants and Time Supports Use of RBD Thresholds to Predict Protective Host Immunity by Kenny, Grace, O’Reilly, Sophie R, Kelly, Neil Wrigley, Negi, Riya, Gaillard, Colette Marie, Alalwan, Dana, Saini, Gurvin, Alrawahneh, Tamara, Francois, Nathan, Angeliadis, Matthew, García-León, Alejandro, Tinago, Willard, Feeney, Eoin R, Cotter, Aoife, de Barra, Eoghan, Yousif, Obada, Horgan, Mary, Doran, Peter, Cox, Rebecca J, O’Shea, Donal, Olesen, Ole, Landay, Alan, Hogan, Andrew, Lelièvre, Jean-Daniel, Gautier, Virginie, Cornely, Oliver A, Mallon, Patrick

“…Abstract Background Although SARS-CoV-2 neutralising antibodies protect against severe COVID-19, whether circulating IgG titres reflect underlying host…”
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2338. Robust and Persistent B Cell Responses Following Third Dose SARS-CoV-2 Vaccine Determine Protection from COVID-19 by Byrne, Joanne, Gu, Lili, García-León, Alejandro, Gaillard, Colette Marie, Tomás-Cortázar, Julen, Negi, Riya, Alalwan, Dana, Saini, Gurvin, Donohue, Sean, Reynolds, Bearach, Kenny, Grace, Leamy, Kelly, O’Gorman, Tessa, O’Broin, Cathal, Savinelli, Stefano, Feeney, Eoin R, Yousif, Obada, Cotter, Aoife, de Barra, Eoghan, Sadlier, Corinna, Landay, Alan, Doran, Peter, Cox, Rebecca J, Olesen, Ole, Lelièvre, Jean-Daniel, Cornely, Oliver A, Gautier, Virginie, Mallon, Patrick

“…Abstract Background The immunological memory to SARS-CoV-2 (SCV-2) vaccination has multiple components, with robust antibody (Ab) and B cell responses…”
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Development of a novel medium throughput flow-cytometry based micro-neutralisation test for SARS-CoV-2 with applications in clinical vaccine trials and antibody screening by Sophie O'Reilly, Grace Kenny, Tamara Alrawahneh, Nathan Francois, Lili Gu, Matthew Angeliadis, Valentin de Masson d'Autume, Alejandro Garcia Leon, Eoin R Feeney, Obada Yousif, Aoife Cotter, Eoghan de Barra, Mary Horgan, Patrick W G Mallon, Virginie Gautier

“…Quantifying neutralising capacity of circulating SARS-COV-2 antibodies is critical in evaluating protective humoral immune responses generated…”
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1959. Lower B-Cell Responses Rather Than Circulating Antibody Titres Are Associated With SARS-CoV-2 Infection Post Third Dose COVID-19 Vaccination by Byrne, Joanne, Gu, Lili, Negi, Riya, Garcia-Leon, Alejandro, Alalwan, Dana, Gaillard, Colette Marie, Saini, Gurvin, Leamy, Kelly, Reynolds, Bearach, O’Gorman, Tessa, Kenny, Grace, O’Broin, Cathal, Feeney, Eoin R, Yousif, Obada, Cotter, Aoife, de Barra, Eoghan, Horgan, Mary, Landay, Alan, Doran, Peter, Gautier, Virginie, Mallon, Patrick

“…Abstract Background Which components of the immune response to SARS-CoV-2 vaccination best protect against subsequent infection remains unclear. We explored…”
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Early-Onset Insulin-Resistant Diabetes in Obese Caucasians Has Features of Typical Type 2 Diabetes, but 3 Decades Earlier by McQuaid, Siobhan, O'Gorman, Donal J, Yousif, Obada, Yeow, Toh Peng, Rahman, Yusof, Gasparro, Declan, Pacini, Giovanni, Nolan, John J

“…Obesity has dramatically increased in Irish adolescents and young adults and is related to changes in physical activity and diet. With this, McQuaid et al…”
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In vivo and in vitro studies of GAD-antibody positive subjects with Type 2 diabetes: A distinct sub-phenotype by O’Gorman, Donal J, Yousif, Obada, Dixon, Gordon, McQuaid, Siobhan, Murphy, Elaine, Rahman, Yousif, Gasparro, Declan, Pacini, Giovanni, Newsholme, Philip, Nolan, John J

“…Abstract The purpose of this study was to determine if immune mechanisms in GAD positive patients’ contribute to the pathogenesis of a specific sub-type of…”
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