Search Results - "Yousefi, Shida"

Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation by Germic, Nina, Frangez, Ziva, Yousefi, Shida, Simon, Hans-Uwe

“…Autophagy is well equipped functionally to isolate microbial pathogens in autophagosomes and to carry out their clearance by dismemberment in the course of…”
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Regulation of the innate immune system by autophagy: neutrophils, eosinophils, mast cells, NK cells by Germic, Nina, Frangez, Ziva, Yousefi, Shida, Simon, Hans-Uwe

“…Autophagy is an evolutionally conserved, highly regulated catabolic process that combines cellular functions required for the regulation of metabolic balance…”
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In vivo evidence for extracellular DNA trap formation by Yousefi, Shida, Simon, Dagmar, Stojkov, Darko, Karsonova, Antonina, Karaulov, Alexander, Simon, Hans-Uwe

“…Extracellular DNA trap formation is a cellular function of neutrophils, eosinophils, and basophils that facilitates the immobilization and killing of invading…”
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Untangling “NETosis” from NETs by Yousefi, Shida, Stojkov, Darko, Germic, Nina, Simon, Dagmar, Wang, Xiaoliang, Benarafa, Charaf, Simon, Hans‐Uwe

“…Neutrophil extracellular trap (NET) formation is a cellular function of neutrophils that facilitates the immobilization and killing of invading microorganisms…”
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Mechanisms of toxicity mediated by neutrophil and eosinophil granule proteins by Gigon, Lea, Yousefi, Shida, Karaulov, Alexander, Simon, Hans-Uwe

“…Neutrophils and eosinophils are granulocytes which are characterized by the presence of granules in the cytoplasm. Granules provide a safe storage site for…”
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Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation by Arnold, Isabelle C, Artola-Borán, Mariela, Tallón de Lara, Paulino, Kyburz, Andreas, Taube, Christian, Ottemann, Karen, van den Broek, Maries, Yousefi, Shida, Simon, Hans-Uwe, Müller, Anne

“…Eosinophils are predominantly known for their contribution to allergy. Here, we have examined the function and regulation of gastrointestinal eosinophils in…”
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ROS and glutathionylation balance cytoskeletal dynamics in neutrophil extracellular trap formation by Stojkov, Darko, Amini, Poorya, Oberson, Kevin, Sokollik, Christiane, Duppenthaler, Andrea, Simon, Hans-Uwe, Yousefi, Shida

“…The antimicrobial defense activity of neutrophils partly depends on their ability to form neutrophil extracellular traps (NETs), but the underlying mechanism…”
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Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways by Dworski, Ryszard, MD, PhD, Simon, Hans-Uwe, MD, PhD, Hoskins, Aimee, RN, BSN, Yousefi, Shida, PhD

“…Background Asthma is a heterogeneous inflammatory airway disorder that involves eosinophilic and noneosinophilic phenotypes. Unlike in healthy lungs,…”
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Necroptosis and neutrophil-associated disorders by Wang, Xiaoliang, Yousefi, Shida, Simon, Hans-Uwe

“…Necroptosis is a form of regulated necrosis and is dependent on a signaling pathway involving receptor interacting protein kinase-3 (RIPK3) and mixed lineage…”
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Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production by Amini, Poorya, Stojkov, Darko, Felser, Andrea, Jackson, Christopher B., Courage, Carolina, Schaller, André, Gelman, Laurent, Soriano, Maria Eugenia, Nuoffer, Jean-Marc, Scorrano, Luca, Benarafa, Charaf, Yousefi, Shida, Simon, Hans-Uwe

“…Optic atrophy 1 (OPA1) is a mitochondrial inner membrane protein that has an important role in mitochondrial fusion and structural integrity. Dysfunctional…”
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Evidence for Lysosomal Dysfunction within the Epidermis in Psoriasis and Atopic Dermatitis by Klapan, Kim, Frangež, Živa, Markov, Nikita, Yousefi, Shida, Simon, Dagmar, Simon, Hans-Uwe

“…Atopic dermatitis and psoriasis are frequent chronic inflammatory skin diseases. Autophagy plays a substantial role in the homeostasis of an organism. Loss or…”
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The Enigma of Eosinophil Degranulation by Fettrelet, Timothée, Gigon, Lea, Karaulov, Alexander, Yousefi, Shida, Simon, Hans-Uwe

“…Eosinophils are specialized white blood cells, which are involved in the pathology of diverse allergic and nonallergic inflammatory diseases. Eosinophils are…”
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NETosis - Does It Really Represent Nature's "Suicide Bomber"? by Yousefi, Shida, Simon, Hans-Uwe

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Adhesion-induced eosinophil cytolysis requires the receptor-interacting protein kinase 3 (RIPK3)–mixed lineage kinase-like (MLKL) signaling pathway, which is counterregulated by autophagy by Radonjic-Hoesli, Susanne, MD, Wang, Xiaoliang, PhD, de Graauw, Elisabeth, MD, Stoeckle, Christina, PhD, Styp-Rekowska, Beata, PhD, Hlushchuk, Ruslan, PhD, Simon, Dagmar, MD, Spaeth, Peter J., PhD, Yousefi, Shida, PhD, Simon, Hans-Uwe, MD, PhD

“…Background Eosinophils are a subset of granulocytes that can be involved in the pathogenesis of different diseases, including allergy. Their effector functions…”
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NADPH oxidase-independent formation of extracellular DNA traps by basophils by Morshed, Mahbubul, Hlushchuk, Ruslan, Simon, Dagmar, Walls, Andrew F, Obata-Ninomiya, Kazushige, Karasuyama, Hajime, Djonov, Valentin, Eggel, Alexander, Kaufmann, Thomas, Simon, Hans-Uwe, Yousefi, Shida

“…Basophils are primarily associated with a proinflammatory and immunoregulatory role in allergic diseases and parasitic infections. Recent studies have shown…”
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Extracellular eosinophilic traps in association with Staphylococcus aureus at the site of epithelial barrier defects in patients with severe airway inflammation by Gevaert, Elien, PhD, Zhang, Nan, MD, PhD, Krysko, Olga, MD, PhD, Lan, Feng, MD, PhD, Holtappels, Gabriële, BSc, De Ruyck, Natalie, MSc, Nauwynck, Hans, PhD, Yousefi, Shida, PhD, Simon, Hans-Uwe, MD, PhD, Bachert, Claus, MD, PhD

“…Background Chronic rhinosinusitis with nasal polyps is characterized by TH 2-biased eosinophilic inflammation. Eosinophils have been shown to generate…”
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Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense by Yousefi, Shida, Simon, Hans-Uwe, Gold, Jeffrey A, Andina, Nicola, Lee, James J, Kelly, Ann M, Kozlowski, Evelyne, Schmid, Inès, Straumann, Alex, Reichenbach, Janine, Gleich, Gerald J

“…Although eosinophils are considered useful in defense mechanisms against parasites, their exact function in innate immunity remains unclear. The aim of this…”
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Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis by Simon, Hans-Uwe, Yousefi, Shida, Perozzo, Remo, Schmid, Inès, Ziemiecki, Andrew, Schaffner, Thomas, Scapozza, Leonardo, Brunner, Thomas

“…Autophagy-related gene (Atg) 5 is a gene product required for the formation of autophagosomes. Here, we report that Atg5, in addition to the promotion of…”
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Autophagy is required for self-renewal and differentiation of adult human stem cells by Salemi, Souzan, Yousefi, Shida, Constantinescu, Mihai A, Fey, Martin F, Simon, Hans-Uwe

“…Dear Editor, Patients receiving anticancer therapy usually suffer from side effects, such as loss of hair, epithelial barrier defects, and myelosuppression,…”
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Regulation of eosinophil functions by autophagy by Germic, Nina, Hosseini, Aref, Yousefi, Shida, Karaulov, Alexander, Simon, Hans-Uwe

“…Eosinophils are granule-containing leukocytes which develop in the bone marrow. For many years, eosinophils have been recognized as cytotoxic effector cells,…”
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