Augmented anticancer effect and antibacterial activity of silver nanoparticles synthesized by using Taxus wallichiana leaf extract

Augmented anticancer effect and antibacterial activity of silver nanoparticles synthesized by using Taxus wallichiana leaf extract

is an evergreen tree species found in the Himalayan region of Pakistan. The tree possesses important secondary metabolites such as Taxol that has been implicated in treating breast, ovarian and colon cancer. Therefore keeping in view the importance of this plant species, silver nanoparticles were sy...

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Bibliographic Details
Published in:PeerJ (San Francisco, CA) Vol. 10; p. e14391
Main Authors: Yousaf, Aliya, Waseem, Muhammad, Javed, Aneela, Baig, Sofia, Ismail, Bushra, Baig, Ayesha, Shahzadi, Irum, Nawazish, Shamyla, Zaman, Iftikhar
Format: Journal Article
Language:English
Published: United States PeerJ, Inc 23-11-2022
PeerJ Inc
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial acticity
Antibacterial activity
Antibiotics
Anticancer
Antitumor activity
Bacteria
Biochemistry
Biotechnology
Brain cancer
Breast cancer
Cell Biology
Cell viability
Colon cancer
Crystals
Cytotoxicity
Flavonoids
Fourier transforms
Glioblastoma
Herbal medicine
Leaves
Metabolites
Metal Nanoparticles - therapeutic use
Microbiology
Nanoparticles
Ovarian cancer
Paclitaxel
Particle size
Phenolic compounds
Plant extracts
Plant Extracts - pharmacology
Scanning electron microscopy
Secondary metabolites
Silver
Silver - pharmacology
Sodium
Spectroscopy, Fourier Transform Infrared
Spectrum analysis
Steroids
Taxus
Taxus wallichiana
X-ray diffraction
United Kingdom > UK
England
Pakistan
Nanoparticles
Taxus wallichiana
Anticancer
Antibacterial acticity
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Summary:is an evergreen tree species found in the Himalayan region of Pakistan. The tree possesses important secondary metabolites such as Taxol that has been implicated in treating breast, ovarian and colon cancer. Therefore keeping in view the importance of this plant species, silver nanoparticles were synthesized using aqueous leaf extract and evaluated for their anti-bacterial and anti-cancer properties. Silver (Ag) nanoparticles (NPs) were characterized for their optical, morphological and structural features using techniques such as UV-visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) and were evaluated for their antibacterial activity and anti-cancer activity using U251 cell line. The study showed that the UV-absorbance peak of Ag O NPs at 450 nm shifted to 410 nm, affirming the formation of leaf extract Ag NPs. Similarly structural studies revealed the crystalline nature of the cubic structure of the Ag crystal with an average crystallite size of 29 nm. FTIR analysis exhibited the existence of different functional elements including O-H and N-H and phenolic groups. Non-spherical glomerular shaped Ag NPs were observed from SEM studies and EDX profile showed Ag as the main element along with constituent of biological origin. The synthesized Ag NPs showed significant antibacterial activity against , and . The cytotoxic activity of Ag NPs on U251 brain cancer cells showed a synergistic effect with 10 ug/mL concentration after 48 and 72 h incubation based on cell viability assay indicating promising glioblastoma drug potential.
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ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.14391