Search Results - "Younsi, Alexander"

Editorial: Neurotrauma and repair: from peripheral to central nerve injury by Younsi, Alexander

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Impact of decompressive laminectomy on the functional outcome of patients with metastatic spinal cord compression and neurological impairment by Younsi, Alexander, Riemann, Lennart, Scherer, Moritz, Unterberg, Andreas, Zweckberger, Klaus

“…Metastatic spinal cord compression (MSCC) is a frequent phenomenon in advanced tumor diseases with often severe neurological impairments. Affected patients are…”
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Microglia: a promising therapeutic target in spinal cord injury by Zha, Xiaowei, Zheng, Guoli, Skutella, Thomas, Kiening, Karl, Unterberg, Andreas, Younsi, Alexander

“…Microglia are present throughout the central nervous system and are vital in neural repair, nutrition, phagocytosis, immunological regulation, and maintaining…”
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Long-Term Effects of Neural Precursor Cell Transplantation on Secondary Injury Processes and Functional Recovery after Severe Cervical Contusion-Compression Spinal Cord Injury by Younsi, Alexander, Zheng, Guoli, Riemann, Lennart, Scherer, Moritz, Zhang, Hao, Tail, Mohamed, Hatami, Maryam, Skutella, Thomas, Unterberg, Andreas, Zweckberger, Klaus

“…Cervical spinal cord injury (SCI) remains a devastating event without adequate treatment options despite decades of research. In this context, the usefulness…”
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Focal lesion size poorly correlates with motor function after experimental traumatic brain injury in mice by Walter, Johannes, Mende, Jannis, Hutagalung, Samuel, Grutza, Martin, Younsi, Alexander, Zheng, Guoli, Unterberg, Andreas W, Zweckberger, Klaus

“…It remains unclear whether neurobehavioral testing adds significant information to histologic assessment of experimental traumatic brain injury (TBI) and if…”
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Axonal Regeneration after Spinal Cord Injury: Molecular Mechanisms, Regulatory Pathways, and Novel Strategies by Elmalky, Mohammed Ibrahim, Alvarez-Bolado, Gonzalo, Younsi, Alexander, Skutella, Thomas

“…Axonal regeneration in the spinal cord after traumatic injuries presents a challenge for researchers, primarily due to the nature of adult neurons and the…”
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Sonic Hedgehog modulates the inflammatory response and improves functional recovery after spinal cord injury in a thoracic contusion–compression model by Zhang, Hao, Younsi, Alexander, Zheng, Guoli, Tail, Mohamed, Harms, Anna-Kathrin, Roth, Judith, Hatami, Maryam, Skutella, Thomas, Unterberg, Andreas, Zweckberger, Klaus

“…Purpose The Sonic Hedgehog (Shh) pathway has been associated with a protective role after injury to the central nervous system (CNS). We, therefore,…”
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Development and Validation of an Automatic Segmentation Algorithm for Quantification of Intracerebral Hemorrhage by Scherer, Moritz, Cordes, Jonas, Younsi, Alexander, Sahin, Yasemin-Aylin, Götz, Michael, Möhlenbruch, Markus, Stock, Christian, Bösel, Julian, Unterberg, Andreas, Maier-Hein, Klaus, Orakcioglu, Berk

“…BACKGROUND AND PURPOSE—ABC/2 is still widely accepted for volume estimations in spontaneous intracerebral hemorrhage (ICH) despite known limitations, which…”
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Exploring the Molecular Tapestry: Organ-Specific Peptide and Protein Ultrafiltrates and Their Role in Therapeutics by Slivka, Jakub Peter, Bauer, Chris, Younsi, Alexander, Wong, Michelle B F, Chan, Mike K S, Skutella, Thomas

“…This study aims to characterize the proteome composition of organ-derived protein extracts from rabbits. Protein isolation was performed using soft…”
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Treadmill training improves survival and differentiation of transplanted neural precursor cells after cervical spinal cord injury by Younsi, Alexander, Zheng, Guoli, Scherer, Moritz, Riemann, Lennart, Zhang, Hao, Tail, Mohamed, Hatami, Maryem, Skutella, Thomas, Unterberg, Andreas, Zweckberger, Klaus

“…•The addition of treadmill training to NPC transplantation increases survival and differentiation of the cell graft 8 weeks after cervical SCI in rats.•The…”
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Post Intensive Care Syndrome in patients sustaining a Traumatic Brain Injury by Grutza, Martin, Walter, Johannes, Unterberg, Andreas, Younsi, Alexander

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Mortality and functional outcome after surgical evacuation of traumatic acute subdural hematomas in octa- and nonagenarians by Younsi, Alexander, Fischer, Jessica, Habel, Cleo, Riemann, Lennart, Scherer, Moritz, Unterberg, Andreas, Zweckberger, Klaus

“…Purpose The incidence of acute subdural hematomas (aSDH) is rising. However, beneficial effects of surgery for the oldest aSDH patients remain unclear. We…”
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The Single-Dose Application of Interleukin-4 Ameliorates Secondary Brain Damage in the Early Phase after Moderate Experimental Traumatic Brain Injury in Mice by Walter, Johannes, Mende, Jannis, Hutagalung, Samuel, Alhalabi, Obada T., Grutza, Martin, Zheng, Guoli, Skutella, Thomas, Unterberg, Andreas, Zweckberger, Klaus, Younsi, Alexander

“…Activation of the interleukin-4 (IL-4) pathway ameliorates secondary injury mechanisms after experimental traumatic brain injury (TBI); therefore, we assessed…”
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Sonic Hedgehog reduces inflammatory response, decreases blood-spinal cord barrier permeability, and improves locomotor function recovery in an acute spinal cord injury rat model by Tail, Mohamed, Zhang, Hao, Zheng, Guoli, Harms, Anna-Kathrin, Hatami, Maryam, Skutella, Thomas, Kiening, Karl, Unterberg, Andreas, Zweckberger, Klaus, Younsi, Alexander

“…Sonic Hedgehog (Shh), extensively researched for its role in early neurogenesis and brain development, has recently been recognized for its neuroprotective…”
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Assessment of hindlimb motor recovery after severe thoracic spinal cord injury in rats: classification of CatWalk XT® gait analysis parameters by Zheng, Guoli, Zhang, Hao, Tail, Mohamed, Wang, Hao, Walter, Johannes, Skutella, Thomas, Unterberg, Andreas, Zweckberger, Klaus, Younsi, Alexander

“…Assessment of locomotion recovery in preclinical studies of experimental spinal cord injury remains challenging. We studied the CatWalk XT® gait analysis for…”
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Molecular characterization of CNS paragangliomas identifies cauda equina paragangliomas as a distinct tumor entity by Schweizer, Leonille, Thierfelder, Felix, Thomas, Christian, Soschinski, Patrick, Suwala, Abigail, Stichel, Damian, Wefers, Annika K., Wessels, Lars, Misch, Martin, Kim, Hee-yeong, Jödicke, Ruben, Teichmann, Daniel, Kaul, David, Kahn, Johannes, Bockmayr, Michael, Hasselblatt, Martin, Younsi, Alexander, Unterberg, Andreas, Knie, Bettina, Walter, Jan, Al Safatli, Diaa, May, Sven-Axel, Jödicke, Andreas, Ntoulias, Georgios, Moskopp, Dag, Vajkoczy, Peter, Heppner, Frank L., Capper, David, Hartmann, Wolfgang, Hartmann, Christian, von Deimling, Andreas, Reuss, David E., Schöler, Anne, Koch, Arend

“…Paragangliomas/pheochromocytomas are rare neuroendocrine tumors that arise from the adrenal gland or ganglia at various sites throughout the body. They display…”
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Prediction model for intracranial hypertension demonstrates robust performance during external validation on the CENTER-TBI dataset by Carra, Giorgia, Güiza, Fabian, Depreitere, Bart, Meyfroidt, Geert

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Transplantation of Neural Precursor Cells Attenuates Chronic Immune Environment in Cervical Spinal Cord Injury by Riemann, Lennart, Younsi, Alexander, Scherer, Moritz, Zheng, Guoli, Skutella, Thomas, Unterberg, Andreas W, Zweckberger, Klaus

“…Inflammation after traumatic spinal cord injury (SCI) is non-resolving and thus still present in chronic injury stages. It plays a key role in the…”
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Spinal oncologic paraparesis: Analysis of neurological and surgical outcomes in patients with intramedullary, extramedullary, and extradural tumors by Alhalabi, Obada T, Heene, Stefan, Landré, Vincent, Neumann, Jan-Oliver, Scherer, Moritz, Ishak, Basem, Kiening, Karl, Zweckberger, Klaus, Unterberg, Andreas W, Younsi, Alexander

“…Paraparesis due to oncologic lesions of the spine warrants swift neurosurgical intervention to prevent permanent disability and hence maintain independence of…”
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Effects of a neurokinin-1 receptor antagonist in the acute phase after thoracic spinal cord injury in a rat model by Zheng, Guoli, Harms, Anna-Kathrin, Tail, Mohamed, Zhang, Hao, Nimmo, Alan, Skutella, Thomas, Kiening, Karl, Unterberg, Andreas, Zweckberger, Klaus, Younsi, Alexander

“…Disruption of the blood-spinal cord barrier (BSCB) with subsequent edema formation and further neuroinflammation contributes to aggravation of spinal cord…”
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