Search Results - "Younkin, Linda H"

Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease by Jankowsky, Joanna L, Melnikova, Tatiana, Fadale, Daniel J, Xu, Guilian M, Slunt, Hilda H, Gonzales, Victoria, Younkin, Linda H, Younkin, Steven G, Borchelt, David R, Savonenko, Alena V

“…Epidemiological studies suggest that individuals with greater education or more cognitively demanding occupations have diminished risk of developing dementia…”
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Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains by Wahrle, Suzanne, Das, Pritam, Nyborg, Andrew C., McLendon, Chris, Shoji, Mikio, Kawarabayashi, Takeshi, Younkin, Linda H., Younkin, Steven G., Golde, Todd E.

“…Buoyant membrane fractions containing presenilin 1 (PS1), an essential component of the γ-secretase complex, and APP CTFβ, a γ-secretase substrate, can be…”
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Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees by Ertekin-Taner, Nilufer, Graff-Radford, Neill, Younkin, Linda H., Eckman, Christopher, Baker, Matthew, Adamson, Jennifer, Ronald, James, Blangero, John, Hutton, Michael, Younkin, Steven G.

“…Plasma Aβ42 (amyloid β42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree…”
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The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice by Wen, Paul H., Hof, Patrick R., Chen, Xiaoping, Gluck, Karen, Austin, Gregory, Younkin, Steven G., Younkin, Linda H., DeGasperi, Rita, Gama Sosa, Miguel A., Robakis, Nikolaos K., Haroutunian, Vahram, Elder, Gregory A.

“…The functions of presenilin 1 (PS1) and how PS1 mutations cause familial Alzheimer's disease (FAD) are incompletely understood. PS1 expression is essential for…”
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Association of Plasma β-Amyloid Level and Cognitive Reserve With Subsequent Cognitive Decline by Yaffe, Kristine, Weston, Andrea, Graff-Radford, Neill R, Satterfield, Suzanne, Simonsick, Eleanor M, Younkin, Steven G, Younkin, Linda H, Kuller, Lewis, Ayonayon, Hilsa N, Ding, Jingzhong, Harris, Tamara B

“…CONTEXT Lower plasma β-amyloid 42 and 42/40 levels have been associated with incident dementia, but results are conflicting and few have investigated cognitive…”
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Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives by Golde, Todd E., Estus, Steven, Younkin, Linda H., Selkoe, Dennis J., Younkin, Steven G.

“…The ∼120-kilodalton amyloid β protein precursor (β APP) is processed into a complex set of 8- to 12-kilodalton carboxyl-terminal derivatives that includes…”
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Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease by Younkin, Steven G, Carrasquillo, Minerva M, Zou, Fanggeng, Pankratz, V Shane, Wilcox, Samantha L, Ma, Li, Walker, Louise P, Younkin, Samuel G, Younkin, Curtis S, Younkin, Linda H, Bisceglio, Gina D, Ertekin-Taner, Nilufer, Crook, Julia E, Dickson, Dennis W, Petersen, Ronald C, Graff-Radford, Neill R

“…By analyzing late-onset Alzheimer's disease (LOAD) in a genome-wide association study (313,504 SNPs, three series, 844 cases and 1,255 controls) and evaluating…”
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Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity by Kotilinek, Linda A., Westerman, Marcus A., Wang, Qinwen, Panizzon, Kimberly, Lim, Giselle P., Simonyi, Agnes, Lesne, Sylvain, Falinska, Agnieszka, Younkin, Linda H., Younkin, Steven G., Rowan, Michael, Cleary, James, Wallis, Roi Ann, Sun, Grace Y., Cole, Greg, Frautschy, Sally, Anwyl, Roger, Ashe, Karen H.

“…Non-steroidal anti-inflammatory agents (NSAIDs) are associated with a marked reduction in the risk of developing Alzheimer's disease, a form of dementia…”
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Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase by Jankowsky, Joanna L., Fadale, Daniel J., Anderson, Jeffrey, Xu, Guilian M., Gonzales, Victoria, Jenkins, Nancy A., Copeland, Neal G., Lee, Michael K., Younkin, Linda H., Wagner, Steven L., Younkin, Steven G., Borchelt, David R.

“…Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and γ-secretase to release amyloid peptides (Aβ40 and 42) that aggregate to form…”
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BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease by Ohno, Masuo, Sametsky, Evgeny A, Younkin, Linda H, Oakley, Holly, Younkin, Steven G, Citron, Martin, Vassar, Robert, Disterhoft, John F

“…β-site APP cleaving enzyme 1 (BACE1) is the β-secretase enzyme required for generating pathogenic β-amyloid (Aβ) peptides in Alzheimer's disease (AD). BACE1…”
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Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease by Kawarabayashi, Takeshi, Shoji, Mikio, Younkin, Linda H, Wen-Lang, Lin, Dickson, Dennis W, Murakami, Tetsuro, Matsubara, Etsuro, Abe, Koji, Ashe, Karen Hsiao, Younkin, Steven G

“…To investigate lipid rafts as a site where amyloid beta protein (Abeta) oligomers might accumulate and cause toxicity in Alzheimer's disease (AD), we analyzed…”
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Persistent Amyloidosis following Suppression of Aβ Production in a Transgenic Model of Alzheimer Disease by Jankowsky, Joanna L, Slunt, Hilda H, Gonzales, Victoria, Savonenko, Alena V, Wen, Jason C, Jenkins, Nancy A, Copeland, Neal G, Younkin, Linda H, Lester, Henry A, Younkin, Steven G, Borchelt, David R

“…Background The proteases (secretases) that cleave amyloid- beta (A beta ) peptide from the amyloid precursor protein (APP) have been the focus of considerable…”
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Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice by Jankowsky, Joanna L., Younkin, Linda H., Gonzales, Victoria, Fadale, Daniel J., Slunt, Hilda H., Lester, Henry A., Younkin, Steven G., Borchelt, David R.

“…The amino acid sequence of amyloid precursor protein (APP) is highly conserved, and age-related Aβ aggregates have been described in a variety of vertebrate…”
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Reduced effectiveness of Aβ1-42 immunization in APP transgenic mice with significant amyloid deposition by DAS, Pritam, PAUL, M, MURPHY, YOUNKIN, Linda H, STEVEN, YOUNKIN, G, GOLDE, Todd E

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Effect of Leuprolide on Serum Amyloid-β Peptide Levels and Memory in Patients With Prostate Cancer With Biochemical Recurrence by Tan, Winston W, Heckman, Michael G, Vishnu, Prakash, Crook, Julia E, Younkin, Linda H, Covil, Edgar G, Ferman, Tanis J, Graff-Radford, Neill R, Younkin, Steven G, Smallridge, Robert C, Wehle, Michael J, Buskirk, Steven J

“…Objective To investigate whether prostate cancer patients receiving leuprolide demonstrated objective cognitive decline accompanied by a change in plasma…”
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ARE PLASMA Aβ MEASURES ASSOCIATED WITH LONGITUDINAL CHANGE IN HIPPOCAMPAL VOLUME? by Crook, Julia E, Graff-Radford, Neill R, Thomas, Colleen S, Younkin, Linda H, Knopman, David S, Boeve, Bradley F, Petersen, Ronald C, Jack, Clifford R, Younkin, Steven G

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Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice by Tucker, H. Michael, Simpson, James, Kihiko-Ehmann, Muthoni, Younkin, Linda H., McGillis, Joseph P., Younkin, Steven G., Degen, Jay L., Estus, Steven

“…Deposition of amyloid beta (Aβ) into extracellular plaques is a pathologic characteristic of Alzheimer’s disease. Plasmin, neprilysin, endothelin-converting…”
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Association of Aβ42, Aβ40 and Aβ2/Aβ40 with cognitive impairment not demented (CIND) and dementia in persons of mexican ancestry (SALSA study): Different for diabetics versus non-diabetics? by Graff-Radford, Neill R, Crook, Julia E, Lucas, John A, Younkin, Linda H, Nah, Gregory, Younkin, Steven G, Haan, Mary N

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Serum creatinine levels correlate with plasma amyloid β protein by ARVANITAKIS, Zoe, LUCAS, John A, YOUNKIN, Linda H, YOUNKIN, Steven G, GRAFF-RADFORD, Neill R

“…The authors investigated the effect of renal function on plasma amyloid beta protein (Abeta) by analyzing the relationship between creatinine (Cr) and Abeta40…”
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High plasma Aβ40 levels are associated with incident Cognitive Impairment not Demented (CIND) and dementia cases in persons of Mexican ancestry (SALSA study) by Graff-Radford, Neill R, Crook, Julia E, Lucas, John A, Younkin, Linda H, Moore, Kari A.B, Younkin, Steven G, Haan, Mary N

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