Search Results - "Younis, Mahmoud A"

Clinical translation of nanomedicines: Challenges, opportunities, and keys by Younis, Mahmoud A., Tawfeek, Hesham M., Abdellatif, Ahmed A.H., Abdel-Aleem, Jelan A., Harashima, Hideyoshi

“…[Display omitted] Despite the massive interest and recent developments in the field of nanomedicine, only a limited number of formulations have found their way…”
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Ultra-small lipid nanoparticles encapsulating sorafenib and midkine-siRNA selectively-eradicate sorafenib-resistant hepatocellular carcinoma in vivo by Younis, Mahmoud A., Khalil, Ikramy A., Elewa, Yaser H.A., Kon, Yasuhiro, Harashima, Hideyoshi

“…Hepatocellular carcinoma (HCC) is a fatal disease with limited therapeutic choices. The stroma-rich tumor microenvironment hinders the in vivo delivery of most…”
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Lipid Nanoparticles for Cell-Specific in Vivo Targeted Delivery of Nucleic Acids by Khalil, Ikramy A., Younis, Mahmoud A., Kimura, Seigo, Harashima, Hideyoshi

“…The last few years have witnessed a great advance in the development of nonviral systems for in vivo targeted delivery of nucleic acids. Lipid nanoparticles…”
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Biomedical Applications of Quantum Dots: Overview, Challenges, and Clinical Potential by Abdellatif, Ahmed A H, Younis, Mahmoud A, Alsharidah, Mansour, Al Rugaie, Osamah, Tawfeek, Hesham M

“…Despite the massive advancements in the nanomedicines and their associated research, their translation into clinically-applicable products is still below…”
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Self-homing nanocarriers for mRNA delivery to the activated hepatic stellate cells in liver fibrosis by Younis, Mahmoud A., Sato, Yusuke, Elewa, Yaser H.A., Kon, Yasuhiro, Harashima, Hideyoshi

“…Herein, we report on the development of a platform for the selective delivery of mRNA to the hard-to-transfect Activated Hepatic Stellate Cells (aHSCs), the…”
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Reprogramming activated hepatic stellate cells by siRNA-loaded nanocarriers reverses liver fibrosis in mice by Younis, Mahmoud A., Sato, Yusuke, Elewa, Yaser H.A., Harashima, Hideyoshi

“…We report on a novel strategy for treating liver fibrosis through reprogramming activated Hepatic Stellate Cells (aHSCs) into quiescent Hepatic Stellate Cells…”
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A Multifunctional Lipid-Based Nanodevice for the Highly Specific Codelivery of Sorafenib and Midkine siRNA to Hepatic Cancer Cells by Younis, Mahmoud A, Khalil, Ikramy A, Abd Elwakil, Mahmoud M, Harashima, Hideyoshi

“…Hepatocellular carcinoma (HCC), a common deadly malignancy, requires novel therapeutic strategies to improve the survival rate. Combining chemotherapy and gene…”
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Inhibitory role of Annexin A1 in pathological bone resorption and therapeutic implications in periprosthetic osteolysis by Alhasan, Hend, Terkawi, Mohamad Alaa, Matsumae, Gen, Ebata, Taku, Tian, Yuan, Shimizu, Tomohiro, Nishida, Yoshio, Yokota, Shunichi, Garcia-Martin, Fayna, M. Abd Elwakil, Mahmoud, Takahashi, Daisuke, Younis, Mahmoud A., Harashima, Hideyoshi, Kadoya, Ken, Iwasaki, Norimasa

“…There is currently no therapy available for periprosthetic osteolysis, the most common cause of arthroplasty failure. Here, the role of AnxA1 in periprosthetic…”
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Techno-economical study of solar water pumping system: optimum design, evaluation, and comparison by Kazem, Hussein A., Quteishat, Anas, Younis, Mahmoud A.

“…Solar water pumping systems are fundamental entities for water transmission and storage purposes whether it is has been used in irrigation or residential…”
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Novel sublingual tablets of Atorvastatin calcium/Trimetazidine hydrochloride combination; HPTLC quantification, in vitro formulation and characterization by Atia, Noha N., Tawfeek, Hesham M., Rageh, Azza H., El-Zahry, Marwa R., Abdelfattah, Ahmed, Younis, Mahmoud A.

“…Ischemic heart disorders and accumulation of lipids in blood vessels could contribute to angina pectoris. Therefore, the aim of this study was to formulate…”
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Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines by Nakamura, Takashi, Sato, Yusuke, Yamada, Yuma, Abd Elwakil, Mahmoud M., Kimura, Seigo, Younis, Mahmoud A., Harashima, Hideyoshi

“…[Display omitted] A new era of nanomedicines that involve nucleic acids/gene therapy has been opened after two decades in 21st century and new types of more…”
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MCT4 knockdown by tumor microenvironment-responsive nanoparticles remodels the cytokine profile and eradicates aggressive breast cancer cells by Abdellatif, Ahmed A.H., Bouazzaoui, Abdellatif, Tawfeek, Hesham M., Younis, Mahmoud A.

“…Breast cancer is a wide-spread threat to the women’s health. The drawbacks of conventional treatments necessitate the development of alternative strategies,…”
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Impact of the functional coating of silver nanoparticles on their in vivo performance and biosafety by Tawfeek, Hesham M., Younis, Mahmoud A., Aldosari, Basmah Nasser, Almurshedi, Alanood Sunhat, Abdelfattah, Ahmed, Abdel-Aleem, Jelan A.

“…Silver nanoparticles (AgNPs) have become an interesting therapeutic modality and drug delivery platform. Herein, we aimed to investigate the impact of…”
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Understanding Gene Involvement in Hepatocellular Carcinoma: Implications for Gene Therapy and Personalized Medicine by Younis, Mahmoud A, Harashima, Hideyoshi

“…Hepatocellular carcinoma (HCC) is the dominant type of liver cancers and is one of the deadliest health threats globally. The conventional therapeutic options…”
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Targeted Nanoparticles: the Smart Way for the Treatment of Colorectal Cancer by Abdellatif, Ahmed A. H., Alshubrumi, Abdulmajeed S., Younis, Mahmoud A.

“…Colorectal cancer (CRC) is a widespread cancer that starts in the digestive tract. It is the third most common cause of cancer deaths around the world. The…”
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Lipid nanoparticles technology in vaccines: Shaping the future of prophylactic medicine by Abdellatif, Ahmed A.H., Younis, Mahmoud A., Alsowinea, Abdullah F., Abdallah, Emad M., Abdel-Bakky, Mohamed S., Al-Subaiyel, Amal, Hassan, Yasser A.H., Tawfeek, Hesham M.

“…Throughout decades, the intrinsic power of the immune system to fight pathogens has inspired researchers to develop techniques that enable the prevention or…”
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Non-coding RNA-directed therapeutics in lung cancer: Delivery technologies and clinical applications by Abdellatif, Ahmed A.H., Scagnetti, Giulia, Younis, Mahmoud A., Bouazzaoui, Abdellatif, Tawfeek, Hesham M., Aldosari, Basmah N., Almurshedi, Alanood S., Alsharidah, Mansour, Rugaie, Osamah Al, Davies, Michael P.A., Liloglou, Triantafillos, Ross, Kehinde, Saleem, Imran

“…Lung cancer is one of the most aggressive and deadliest health threats. There has been an increasing interest in non-coding RNA (ncRNA) recently, especially in…”
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Gene Therapy for Hepatocellular Carcinoma: Highlighting the Journey from Theory to Clinical Applications by Younis, Mahmoud A., Khalil, Ikramy A., Harashima, Hideyoshi

“…Treatment for hepatocellular carcinoma (HCC) is currently limited to early stages where surgical intervention is applicable. Meanwhile, the response for most…”
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Sulpiride gastro-retentive floating microsponges; analytical study, in vitro optimization and in vivo characterization by Younis, Mahmoud A., El-Zahry, Marwa R., Tallat, Mahmoud A., Tawfeek, Hesham M.

“…Sulpiride (SUL), anti-dopaminergic drug, has a specific site for absorption located in the upper portion of the gastrointestinal tract hence, its oral delivery…”
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Chitosan-capped silver nanoparticles with potent and selective intrinsic activity against the breast cancer cells by Abdellatif, Ahmed A. H., Abdelfattah, Ahmed, Younis, Mahmoud A., Aldalaan, Saed M., Tawfeek, Hesham M.

“…Herein, we report on the development of chitosan-capped silver nanoparticles (AgNPs-CHI) with an intrinsic activity against breast cancer cells. Following…”
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