Search Results - "Youngman, Mark"

The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure by Cadilla, Rodolfo, Deaton, David N., Do, Young, Elkins, Patricia A., Ennulat, Daniela, Guss, Jeffrey H., Holt, Jason, Jeune, Michael R., King, Andrew G., Klapwijk, Jan C., Kramer, H. Fritz, Kramer, Nicholas J., Laffan, Susan B., Masuria, Paresh I., McDougal, Alan V., Mortenson, Paul N., Musetti, Caterina, Peckham, Gregory E., Pietrak, Beth L., Poole, Chuck, Price, Daniel J., Rendina, Alan R., Sati, Girish, Saxty, Gordon, Shearer, Barry G., Shewchuk, Lisa M., Sneddon, Helen F., Stewart, Eugene L., Stuart, J. Darren, Thomas, Dean N., Thomson, Stephen A., Ward, Paris, Wilson, Joseph W., Xu, Tiahshun, Youngman, Mark A.

“…[Display omitted] GlaxoSmithKline and Astex Pharmaceuticals recently disclosed the discovery of the potent H-PGDS inhibitor GSK2894631A 1a (IC50 = 9.9 nM) as…”
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Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]‑1H‑benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep) by Parsons, William H, Calvo, Raul R, Cheung, Wing, Lee, Yu-Kai, Patel, Sharmila, Liu, Jian, Youngman, Mark A, Dax, Scott L, Stone, Dennis, Qin, Ning, Hutchinson, Tasha, Lubin, Mary Lou, Zhang, Sui-Po, Finley, Michael, Liu, Yi, Brandt, Michael R, Flores, Christopher M, Player, Mark R

“…Reported herein is the design, synthesis, and pharmacologic characterization of a class of TRPV1 antagonists constructed on a benzo­[d]­imidazole platform that…”
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The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists by Matthews, Jay M., Qin, Ning, Colburn, Raymond W., Dax, Scott L., Hawkins, Mike, McNally, James J., Reany, Laura, Youngman, Mark A., Baker, Judith, Hutchinson, Tasha, Liu, Yi, Lubin, Mary Lou, Neeper, Michael, Brandt, Michael R., Stone, Dennis J., Flores, Christopher M.

“…The synthesis and structure–activity relationships of a series of potent benzothiophene-based phosphonates, exemplied by 9l, are reported. A series of…”
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Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists by Zhu, Bin, Xia, Mingde, Xu, Xiaoqing, Ludovici, Donald W., Tennakoon, Manomi, Youngman, Mark A., Matthews, Jay M., Dax, Scott L., Colburn, Raymond W., Qin, Ning, Hutchinson, Tasha L., Lubin, Mary Lou, Brandt, Michael R., Stone, Dennis J., Flores, Christopher M., Macielag, Mark J.

“…A series of arylglycine-based analogs was synthesized and tested for TRPM8 antagonism in a cell-based functional assay. Following structure–activity…”
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Building "Terrorism Studies" as an Interdisciplinary Space: Addressing Recurring Issues in the Study of Terrorism by Youngman, Mark

“…Over the years, there have been many debates regarding the state of research into terrorism and whether "terrorism studies" constitutes an academic discipline…”
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Broader, vaguer, weaker: The evolving ideology of the Caucasus Emirate leadership by Youngman, Mark

“…In October 2007, veteran Chechen field commander Dokka Umarov proclaimed the formation of the Caucasus Emirate (IK), formalising the victory of the North…”
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Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1 by Jetter, Michele C., Youngman, Mark A., McNally, James J., McDonnell, Mark E., Zhang, Sui-Po, Dubin, Adrienne E., Nasser, Nadia, Codd, Ellen E., Flores, Christopher M., Dax, Scott L.

“…The synthesis and biological activity of a series of aminotetralin-derived heteroaryl urea TRPV1 antagonists is reported. We report on a series of…”
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Crossing the Rubicon: The Limits of Insurgent Violence in Kabardino-Balkaria by Youngman, Mark

“…In the 2000s, relations between an overt Islamic social movement and religious and political authorities in the southern Russian republic of Kabardino-Balkaria…”
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Ideology along the Contours of Power: The Case of the Caucasus Emirate by Youngman, Mark

“…The proclamation of the Caucasus Emirate (Imarat Kavkaz, or IK) in October 2007 marked a watershed moment in the evolution of conflict in the North Caucasus,…”
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N-Pyridin-3-yl- and N-quinolin-3-yl-benzamides: Modulators of Human Vanilloid Receptor 1 (TRPV1) by Jetter, Michele C., McNally, James J., Youngman, Mark A., McDonnell, Mark E., Dubin, Adrienne E., Nasser, Nadia, Zhang, Sui-Po, Codd, Ellen E., Colburn, Ray W., Stone, Dennis R., Brandt, Michael R., Flores, Christopher M., Dax, Scott L.

“…The synthesis and biological activity of a series of 3-quinolinyl p-aminobenzamide TRPV1 antagonists are reported. High throughput screening of our compound…”
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N-Isoquinolin-5-yl- N′-aralkyl-urea and -amide antagonists of human vanilloid receptor 1 by Jetter, Michele C., Youngman, Mark A., McNally, James J., Zhang, Sui-Po, Dubin, Adrienne E., Nasser, Nadia, Dax, Scott L.

“…N-Isoquinolin-5-yl- N′-aralkyl-ureas and -amides were developed as potent ligands of human vanilloid receptor 1. N-Isoquinolin-5-yl-…”
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Violent Mobilization and Non-Mobilization in the North Caucasus by Wilhelmsen, Julie, Youngman, Mark

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Novel non-peptidic neuropeptide Y Y2 receptor antagonists by JABLONOWSKI, Jill A, WENYING CHAI, CARRUTHERS, Nicholas I, XIAOBING LI, RUDOLPH, Dale A, MURRAY, William V, YOUNGMAN, Mark A, DAX, Scott L, NEPOMUCENO, Diane, BONAVENTURE, Pascal, LOVENBERG, Timothy W

“…Through SAR studies of a piperidinylindoline cinnamide HTS lead, the first potent, non-peptide, low molecular weight selective Neuropeptide Y Y2 (NPY Y2)…”
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Voices of the Caucasus: mapping knowledge production on the Caucasus region by Jumayeva, Lala, Gunya, Aleksey, Youngman, Mark, Kurbanova, Lidia, Kemoklidze, Nino

“…There is growing recognition that diversity and representation matter to the intellectual health of fields and disciplines. This article takes stock of…”
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α-Substituted N-(Sulfonamido)alkyl-β-aminotetralins:  Potent and Selective Neuropeptide Y Y5 Receptor Antagonists by Youngman, Mark A, McNally, James J, Lovenberg, Timothy W, Reitz, Allen B, Willard, Nicole M, Nepomuceno, Diane H, Wilson, Sandy J, Crooke, Jeffrey J, Rosenthal, Daniel, Vaidya, Anil H, Dax, Scott L

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Design and synthesis of novel pyrrolidine-containing bradykinin antagonists by Lee, Jung, Reynolds, Charles, Jetter, Michele C, Youngman, Mark A, Hlasta, Dennis J, Dax, Scott L, Stone, Dennis J, Zhang, Sui-Po, Codd, Ellen E

“…The design and synthesis of novel pyrrolidine-containing bradykinin antagonists, II, are described. Conformational analysis suggested that a pyrrolidine moiety…”
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Mannich reactions of resin-bound substrates: 2. A versatile three-component solid-phase organic synthesis methodology by McNally, James J., Youngman, Mark A., Dax, Scott L.

“…Alkynes, secondary amines and aldehydes, in the presence of a copper (I) salt, undergo Mannich reactions to afford the corresponding aminomethylalkynyl adducts…”
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Interpreting the Ideological Evolution of an Insurgency : Lessons from the North Caucasus, 2007-2015 by Youngman, Mark

“…Ideology has fallen badly out of fashion. In the study of political violence in particular, it is often pushed to the margins, and there is considerable…”
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N-Acylated α-(3-pyridylmethyl)-β-aminotetralin antagonists of the human neuropeptide Y Y5 receptor by McNally, James J, Youngman, Mark A, Lovenberg, Timothy W, Nepomuceno, Diane, Wilson, Sandy, Dax, Scott L

“…α-(3-Pyridylmethyl)-β-aminotetralins were acylated with amino-piperidinyl and-pyrrolidinyl acetic acids, and with (aminomethyl)cyclohexanecarboxylic acid…”
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Synthesis and structure–Activity relationships of aroylpyrrole alkylamide bradykinin (B 2) antagonists by Youngman, Mark A., Carson, John R., Lee, Jung S., Dax, Scott L., Zhang, Sui-Po, Colburn, Ray W., Stone, Dennis J., Codd, Ellen E., Jetter, Michele C.

“…The synthesis and structure–activity relationships of a novel series of aroylpyrrole alkylamides as potent selective bradykinin B 2 receptor antagonists are…”
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