Search Results - "Younghusband, Banfield H."

Prediction of Lynch Syndrome in Consecutive Patients With Colorectal Cancer by Green, Roger C., Parfrey, Patrick S., Woods, Michael O., Younghusband, H. Banfield

“…Background Lynch syndrome is caused by inherited mutations in DNA mismatch repair genes (primarily MSH2, MLH1, MSH6, and PMS2) and is one of the most prevalent…”
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Case–Control Study of Overweight, Obesity, and Colorectal Cancer Risk, Overall and by Tumor Microsatellite Instability Status by Campbell, Peter T., Jacobs, Elizabeth T., Ulrich, Cornelia M., Figueiredo, Jane C., Poynter, Jenny N., McLaughlin, John R., Haile, Robert W., Jacobs, Eric J., Newcomb, Polly A., Potter, John D., Le Marchand, Loïc, Green, Roger C., Parfrey, Patrick, Younghusband, H. Banfield, Cotterchio, Michelle, Gallinger, Steven, Jenkins, Mark A., Hopper, John L., Baron, John A., Thibodeau, Stephen N., Lindor, Noralane M., Limburg, Paul J., Martínez, María Elena

“…Background Being overweight or obese is an established risk factor for colorectal cancer, more so for men than for women. Approximately 10%–20% of colorectal…”
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Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients by RAWSON, James B, MANNO, Michael, GREEN, Roger C, GALLINGER, Steven, MCLAUGHLIN, John R, KNIGHT, Julia A, BAPAT, Bharati, MRKONJIC, Miralem, DAFTARY, Darshana, DICKS, Elizabeth, BUCHANAN, Daniel D, BANFIELD YOUNGHUSBAND, H, PARFREY, Patrick S, YOUNG, Joanne P, POLLETT, Aaron

“…Aberrant activation of canonical Wnt signaling is a hallmark event in colorectal carcinogenesis. The Dickkopf-1 (DKK1) and Secreted Frizzled Related Protein 1…”
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A new variant database for mismatch repair genes associated with Lynch syndrome by Woods, Michael O., Williams, Phillip, Careen, Amanda, Edwards, Laura, Bartlett, Sylvia, McLaughlin, John R., Younghusband, H. Banfield

“…Mutations in some mismatch repair (MMR) genes are associated with Lynch syndrome (LS; also called hereditary nonpolyposis colorectal cancer [HNPCC]), an…”
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MTHFR Glu429Ala and ERCC5 His46His polymorphisms are associated with prognosis in colorectal cancer patients: analysis of two independent cohorts from Newfoundland by Negandhi, Amit A, Hyde, Angela, Dicks, Elizabeth, Pollett, William, Younghusband, Banfield H, Parfrey, Patrick, Green, Roger C, Savas, Sevtap

“…In this study, 27 genetic polymorphisms that were previously reported to be associated with clinical outcomes in colorectal cancer patients were investigated…”
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Serotonin transporter gene (SLC6A4) variations are associated with poor survival in colorectal cancer patients by Savas, Sevtap, Hyde, Angela, Stuckless, Susan N, Parfrey, Patrick, Younghusband, H Banfield, Green, Roger

“…Prognosis in colorectal cancer patients is quite variable, even after adjustment for clinical parameters such as disease stage and microsatellite instability…”
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Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer by Mrkonjic, Miralem, Roslin, Nicole M, Greenwood, Celia M, Raptis, Stavroula, Pollett, Aaron, Laird, Peter W, Pethe, Vaijayanti V, Chiang, Theodore, Daftary, Darshana, Dicks, Elizabeth, Thibodeau, Stephen N, Gallinger, Steven, Parfrey, Patrick S, Younghusband, H Banfield, Potter, John D, Hudson, Thomas J, McLaughlin, John R, Green, Roger C, Zanke, Brent W, Newcomb, Polly A, Paterson, Andrew D, Bapat, Bharati

“…We previously identified an association between a mismatch repair gene, MLH1, promoter SNP (rs1800734) and microsatellite unstable (MSI-H) colorectal cancers…”
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Increased Cancer Predisposition in Family Members of Colorectal Cancer Patients Harboring the p.V600E BRAF Mutation: a Population-Based Study by WISH, Tyler A, HYDE, Angela J, MCLAUGHLIN, John R, WOODS, Michael O, GREEN, Roger C, PARFREY, Patrick S, GREEN, Jane S, BANFIELD YOUNGHUSBAND, H, SIMMS, Michelle I, FONTAINE, Dan G, DICKS, Elizabeth L, STUCKLESS, Susan N, GALLINGER, Steven

“…The serrated pathway represents a distinct molecular pathway of colorectal carcinogenesis and is associated with the p.V600E BRAF mutation. The objective of…”
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Cytochrome P450 17A1 and Catechol O-Methyltransferase Polymorphisms and Age at Lynch Syndrome Colon Cancer Onset in Newfoundland by CAMPBELL, Peter T, EDWARDS, Laura, MCLAUGHLIN, John R, GREEN, Jane, BANFIELD YOUNGHUSBAND, H, WOODS, Michael O

“…Purpose: Lynch syndrome is a cancer predisposition syndrome which includes colon cancer. It is caused by inherited defects in DNA mismatch repair genes…”
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High Frequency of Hereditary Colorectal Cancer in Newfoundland Likely Involves Novel Susceptibility Genes by WOODS, Michael O, HYDE, Angela J, CHAULK, Jason A. W, JEGATHESAN, Jegan, MCLAUGHLIN, John R, GALLINGER, Steven S, YOUNGHUSBAND, H. Banfield, BAPAT, Bharati V, PARFREY, Patrick S, CURTIS, Fiona K, STUCKLESS, Susan, GREEN, Jane S, POLLETT, Aaron F, ROBB, J. Desmond, GREEN, Roger C, CROITORU, Marina E, CAREEN, Amanda

“…Purpose: Newfoundland has one of the highest rates of colorectal cancer in North America. The most common hereditary form of colorectal cancer is hereditary…”
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dbCPCO: a database of genetic markers tested for their predictive and prognostic value in colorectal cancer by Savas, Sevtap, Younghusband, H. Banfield

“…Colorectal cancer is the third most common cancer with a 5-year survival rate of 30-65%. A portion of the interpatient variability in its clinical outcome is…”
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Inherited deleterious variants in GALNT12 are associated with CRC susceptibility by Clarke, Erica, Green, Roger C., Green, Jane S., Mahoney, Krista, Parfrey, Patrick S., Younghusband, H. Banfield, Woods, Michael O.

“…A recent report detailed the occurrence of both somatic and constitutional variants in the GALNT12 gene, located at 9q22.33, in some colorectal cancer (CRC)…”
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MLH1 –93G>A Promoter Polymorphism and the Risk of Microsatellite-Unstable Colorectal Cancer by Raptis, Stavroula, Mrkonjic, Miralem, Green, Roger C., Pethe, Vaijayanti V., Monga, Neerav, Chan, Yuen Man, Daftary, Darshana, Dicks, Elizabeth, Younghusband, Banfield H., Parfrey, Patrick S., Gallinger, Steven S., McLaughlin, John R., Knight, Julia A., Bapat, Bharati

“…Background Although up to 30% of patients with colorectal cancer have a positive family history of colorectal neoplasia, few colorectal cancers can be…”
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Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22 by Cicek, Mine S, Cunningham, Julie M, Fridley, Brooke L, Serie, Daniel J, Bamlet, William R, Diergaarde, Brenda, Haile, Robert W, Le Marchand, Loic, Krontiris, Theodore G, Younghusband, H Banfield, Gallinger, Steven, Newcomb, Polly A, Hopper, John L, Jenkins, Mark A, Casey, Graham, Schumacher, Fredrick, Chen, Zhu, DeRycke, Melissa S, Templeton, Allyson S, Winship, Ingrid, Green, Roger C, Green, Jane S, Macrae, Finlay A, Parry, Susan, Young, Graeme P, Young, Joanne P, Buchanan, Daniel, Thomas, Duncan C, Bishop, D Timothy, Lindor, Noralane M, Thibodeau, Stephen N, Potter, John D, Goode, Ellen L

“…A substantial proportion of familial colorectal cancer (CRC) is not a consequence of known susceptibility loci, such as mismatch repair (MMR) genes, supporting…”
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Identification of a Novel Gene ( HSN2) Causing Hereditary Sensory and Autonomic Neuropathy Type II through the Study of Canadian Genetic Isolates by Lafrenière, Ronald G., MacDonald, Marcia L.E., Dubé, Marie-Pierre, MacFarlane, Julie, O’Driscoll, Mary, Brais, Bernard, Meilleur, Sébastien, Brinkman, Ryan R., Dadivas, Owen, Pape, Terry, Platon, Christèle, Radomski, Chris, Risler, Jenni, Thompson, Jay, Guerra-Escobio, Ana-Maria, Davar, Gudarz, Breakefield, Xandra O., Pimstone, Simon N., Green, Roger, Pryse-Phillips, William, Goldberg, Y. Paul, Younghusband, H. Banfield, Hayden, Michael R., Sherrington, Robin, Rouleau, Guy A., Samuels, Mark E.

“…Hereditary sensory and autonomic neuropathy (HSAN) type II is an autosomal recessive disorder characterized by impairment of pain, temperature, and touch…”
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MSH2 −118T>C and MSH6 −159C>T promoter polymorphisms and the risk of colorectal cancer by Mrkonjic, Miralem, Raptis, Stavroula, Green, Roger C., Monga, Neerav, Daftary, Darshana, Dicks, Elizabeth, Younghusband, H.Banfield, Parfrey, Patrick S., Gallinger, Steven S., McLaughlin, John R., Knight, Julia A., Bapat, Bharati

“…The most important indicator of colorectal cancer (CRC) risk is the presence of family history of the disease. Inherited genetic changes, such as single…”
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Correction: Colorectal Cancer Linkage on Chromosomes 4q21, 8q13, 12q24, and 15q22 by Cicek, Mine S., Cunningham, Julie M., Fridley, Brooke L., Serie, Daniel J., Bamlet, William R., Diergaarde, Brenda, Haile, Robert W., Le Marchand, Loic, Krontiris, Theodore G., Younghusband, H. Banfield, Gallinger, Steven, Newcomb, Polly A., Hopper, John L., Jenkins, Mark A., Casey, Graham, Schumacher, Fredrick, Chen, Zhu, DeRycke, Melissa S., Templeton, Allyson S., Winship, Ingrid, Green, Roger C., Green, Jane S., Macrae, Finlay A., Parry, Susan, Young, Graeme P., Young, Joanne P., Buchanan, Daniel, Thomas, Duncan C., Bishop, D. Timothy, Lindor, Noralane M., Thibodeau, Stephen N., Potter, John D., Goode, Ellen L.

“…The correct table can be found here: thumbnail Download: * PPT PowerPoint slide * PNG larger image * TIFF original image Figures Citation: Cicek MS, Cunningham…”
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Response: Re: MLH1 −93G>A Promoter Polymorphism and the Risk of Microsatellite-Unstable Colorectal Cancer by Raptis, Stavroula, Mrkonjic, Miralem, Green, Roger C., Daftary, Darshana, Pethe, Vaijayanti, Dicks, Elizabeth, Younghusband, Banfield H., Parfrey, Patrick S., Gallinger, Steven S., McLaughlin, John R., Knight, Julia A., Bapat, Bharati

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Cancer Risk Analysis in Families With Hereditary Nonpolyposis Colorectal Cancer by Kokuer, M., Naguib, R.N.G., Jancovic, P., Younghusband, H.B., Green, R.C.

“…Colorectal cancer (CRC) is one of the most common fatal cancers in developed countries and represents a significant public-health issue. About 3%-5% of…”
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A Comparison of Multi-Layer Neural Network and Logistic Regression in Hereditary Non-Polyposis Colorectal Cancer Risk Assessment by Kokuer, M., Naguib, R.N.G., Jancovic, P., Younghusband, H.B., Green, R.

“…Hereditary non-polyposis colorectal cancer (HN-PCC) is one of the most common autosomal dominant diseases in developed countries. Here, we report on a system…”
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