Search Results - "Young Seob Gwak"

Phenyl N-tert-butylnitrone, a Free Radical Scavenger, Reduces Mechanical Allodynia in Chemotherapy-induced Neuropathic Pain in Rats by HEE KEE KIM, YAN PING ZHANG, YOUNG SEOB GWAK, ABDI, Salahadin

“…Paclitaxel is a widely used chemotherapeutic drug for breast and ovarian cancer. Unfortunately, it induces neuropathic pain, which is a dose-limiting side…”
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Spinal AMPA receptor inhibition attenuates mechanical allodynia and neuronal hyperexcitability following spinal cord injury in rats by Gwak, Young Seob, Kang, Jonghoon, Leem, Joong Woo, Hulsebosch, Claire E.

“…In this study, we examined whether a competitive AMPA receptor antagonist, NBQX, attenuates mechanical allodynia and hyperexcitability of spinal neurons in…”
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The role of substance P in acupuncture signal transduction and effects by Fan, Yu, Kim, Do-Hee, Gwak, Young Seob, Ahn, Danbi, Ryu, Yeonhee, Chang, Suchan, Lee, Bong Hyo, Bills, Kyle B., Steffensen, Scott C., Yang, Chae Ha, Kim, Hee Young

“…•Acupoints display cutaneous neurogenic inflammation from substance P (SP) release.•The topical changes in acupoints precede the onset of pathological…”
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Bilateral hyperexcitability of thalamic VPL neurons following unilateral spinal injury in rats by Gwak, Young Seob, Kim, Hee Kee, Kim, Hee Young, Leem, Joong Woo

“…In the present study, we have examined whether spinal hemisection injury induces changes in the electrophysiological properties of thalamic ventral…”
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Attenuation of mechanical hyperalgesia following spinal cord injury by administration of antibodies to nerve growth factor in the rat by Gwak, Young Seob, Nam, Taick Sang, Paik, Kwang Se, Hulsebosch, Claire E, Leem, Joong Woo

“…Spinal cord injury (SCI) often leads to central pain syndrome including hyperalgesia to mechanical stimulation. Since there is evidence that nerve growth…”
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Activation of p38 MAP kinase is involved in central neuropathic pain following spinal cord injury by Crown, Eric D., Gwak, Young Seob, Ye, Zaiming, Johnson, Kathia M., Hulsebosch, Claire E.

“…Recent work regarding chronic central neuropathic pain (CNP) following spinal cord injury (SCI) suggests that activation of key signaling molecules such as…”
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Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat by Gwak, Young Seob, Crown, Eric D., Unabia, Geda C., Hulsebosch, Claire E.

“…In this study, we evaluated whether propentofylline, a methylxanthine derivative, modulates spinal glial activation and GABAergic inhibitory tone by modulation…”
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An electrophysiological method for quantifying neuropathic pain behaviors in rats: measurement of hindlimb withdrawal EMG magnitude by Kim, Hee Young, Gwak, Young Seob, Shim, Insop

“…In behavior methods to quantify neuropathic pain, visual observations of limb-withdrawal reflexes to stimuli are not always clear-cut, so this method is partly…”
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Neuronal Hyperexcitability: A Substrate for Central Neuropathic Pain After Spinal Cord Injury by Gwak, Young Seob, Hulsebosch, Claire E.

“…Neuronal hyperexcitability produces enhanced pain transmission in the spinal dorsal horn after spinal cord injury (SCI). Spontaneous and evoked neuronal…”
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Spinal pathways involved in somatosensory inhibition of the psychomotor actions of cocaine by Chang, Suchan, Ryu, Yeonhee, Gwak, Young Seob, Kim, Nam Jun, Kim, Jin Mook, Lee, Jun Yeon, Kim, Seol Ah, Lee, Bong Hyo, Steffensen, Scott C., Jang, Eun Young, Yang, Chae Ha, Kim, Hee Young

“…Previous studies have demonstrated that somatosensory stimuli influence dopamine transmission in the mesolimbic reward system and can reduce drug-induced motor…”
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Comparison of Mechanical Allodynia and Recovery of Locomotion and Bladder Function by Different Parameters of Low Thoracic Spinal Contusion Injury in Rats by Carter, Michael W, Johnson, Kathia M, Lee, Jun Yeon, Hulsebosch, Claire E, Gwak, Young Seob

“…Background: The present study was designed to examine the functional recovery following spinal cord injury (SCI) by adjusting the parameters of impact force…”
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Activation of spinal GABA receptors attenuates chronic central neuropathic pain after spinal cord injury by Gwak, Young Seob, Tan, Huai Yu, Nam, Taick Sang, Paik, Kwang Se, Hulsebosch, Claire E, Leem, Joong Woo

“…In this study, we investigated the role of the spinal GABAergic system in central neuropathic painlike outcomes following spinal cord injury (SCI) produced by…”
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Ionotropic glutamate receptors contribute to maintained neuronal hyperexcitability following spinal cord injury in rats by Leem, Joong Woo, Kim, Hee Kee, Hulsebosch, Claire E., Gwak, Young Seob

“…In this study, we examined whether topical treatment of glutamate receptor antagonists attenuate hyperexcitability of lumbar spinal dorsal horn neurons…”
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Upregulation of Group I metabotropic glutamate receptors in neurons and astrocytes in the dorsal horn following spinal cord injury by Gwak, Young Seob, Hulsebosch, Claire E.

“…Of the glutamate receptor types, the metabotropic glutamate receptors (mGluRs) are G proteins coupled and can initiate a number of intracellular pathways…”
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Oxidative Damage in Tissues of Rats Exposed to Cigarette Smoke by Park, Eun-Mi, Park, Young-Mee, Gwak, Young-Seob

“…Cigarette smoke is known to contain high concentrations of free radicals and oxidants. To examine the oxidative effect of cigarette smoking, we subjected rats…”
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Effect of age at time of spinal cord injury on behavioral outcomes in rat by Gwak, Young Seob, Hains, Bryan C, Johnson, Kathia M, Hulsebosch, Claire E

“…Spinal cord injury (SCI) often leads to chronic central pain (CCP) syndromes such as allodynia and hyperalgesia. Although several experimental animal models…”
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Locomotor recovery and mechanical hyperalgesia following spinal cord injury depend on age at time of injury in rat by Gwak, Young Seob, Hains, Bryan C., Johnson, Kathia M., Hulsebosch, Claire E.

“…We tested the effect of age at the time of spinal cord injury (SCI) on locomotor recovery, in open field tests, and mechanical hyperalgesia, using paw…”
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Calcium-independent phospholipase A2 inhibitor produces an analgesic effect in a rat model of neuropathic pain by reducing central sensitization in the dorsal horn by Gwak, Young Seob, Chen, Guanxing, Abdi, Salahadin, Kim, Hee Kee

“…Phospholipase A2 (PLA2) plays an important role in regulating the production of arachidonic acid and various eicosanoids. The aim of our study was to…”
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실험연구 : 척수손상 후 척수 내 GABA 체계의 손실이 중추 신경병증성 통증 유발의 원인이라는 행동학적 및 전기생리학적인 증거 by 곽영섭, Young Seob Gwak, 심범, Beom Shim, 윤덕미, Duck Mi Yoon, 남택상, Taick Sang Nam, 백광세, Kwang Se Paik, 임중우, Joong Woo Leem

“…Background: Allodynia, hyperalgesia, and spontaneous pain are symptoms characterized by chronic central pain which was frequently observed following a spinal…”
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신경병증성 통증모델 쥐에서 피부통각수용체의 민감화 by 심범, Beom Shim, 곽영섭, Young Seob Gwak, 임중우, Joong Woo Leem, 남택상, Taick Sang Nam, 백광세, Kwang Se Paik, 윤덕미, Duck Mi Yoon

“…Background: Peripheral nerve injury leads to neuropathic pain. Although it has been accepted that both peripheral and central processes may play a role in the…”
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