Search Results - "Young, Trevor L"

An updated meta-analysis of oxidative stress markers in bipolar disorder by Brown, Nicole C, Andreazza, Ana C, Young, L. Trevor

“…Abstract Despite its debilitating symptoms, the pathophysiology of bipolar disorder (BD) remains unclear. One consistently compelling finding, however, has…”
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Treatment-Specific Changes in Decentering Following Mindfulness-Based Cognitive Therapy Versus Antidepressant Medication or Placebo for Prevention of Depressive Relapse by Bieling, Peter J., Hawley, Lance L., Bloch, Richard T., Corcoran, Kathleen M., Levitan, Robert D., Young, L. Trevor, MacQueen, Glenda M., Segal, Zindel V.

“…Objective: To examine whether metacognitive psychological skills, acquired in mindfulness-based cognitive therapy (MBCT), are also present in patients…”
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Accelerated Lifetime Testing of Organic–Inorganic Perovskite Solar Cells Encapsulated by Polyisobutylene by Shi, Lei, Young, Trevor L, Kim, Jincheol, Sheng, Yun, Wang, Lei, Chen, Yifeng, Feng, Zhiqiang, Keevers, Mark J, Hao, Xiaojing, Verlinden, Pierre J, Green, Martin A, Ho-Baillie, Anita W. Y

“…Metal halide perovskite solar cells (PSCs) have undergone rapid progress. However, unstable performance caused by sensitivity to environmental moisture and…”
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Neuropathological relationship between major depression and dementia: A hypothetical model and review by Kim, Helena Kyunghee, Nunes, Paula Villela, Oliveira, Katia C., Young, L. Trevor, Lafer, Beny

“…Major depression (MDD) is a chronic psychiatric condition in which patients often show increasing cognitive impairment with recurring episodes…”
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Prevalence and health care costs of mitochondrial disease in Ontario, Canada: A population-based cohort study by Buajitti, Emmalin, Rosella, Laura C, Zabzuni, Ersi, Young, L Trevor, Andreazza, Ana C

“…Mitochondrial disease prevalence has been estimated at 1 in 4000 in the United States, and 1 in 5000 worldwide. Prevalence in Canada has not been established,…”
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Toward Clinically Applicable Biomarkers in Bipolar Disorder: Focus on BDNF, Inflammatory Markers, and Endothelial Function by Goldstein, Benjamin I., Young, L. Trevor

“…The importance of biomarkers to many branches of medicine is illustrated by their utility in diagnosis and monitoring treatment response and outcome. There is…”
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Biomarkers in bipolar disorder: A positional paper from the International Society for Bipolar Disorders Biomarkers Task Force by Frey, Benicio N, Andreazza, Ana C, Houenou, Josselin, Jamain, Stéphane, Goldstein, Benjamin I, Frye, Mark A, Leboyer, Marion, Berk, Michael, Malhi, Gin S, Lopez-Jaramillo, Carlos, Taylor, Valerie H, Dodd, Seetal, Frangou, Sophia, Hall, Geoffrey B, Fernandes, Brisa S, Kauer-Sant’Anna, Marcia, Yatham, Lakshmi N, Kapczinski, Flavio, Young, L Trevor

“…Although the etiology of bipolar disorder remains uncertain, multiple studies examining neuroimaging, peripheral markers and genetics have provided important…”
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The neurobiology of bipolar disorder: identifying targets for specific agents and synergies for combination treatment by Andreazza, Ana C., Young, L. Trevor

“…Bipolar disorder (BD) is a chronic psychiatric illness described by severe changes in mood. Extensive research has been carried out to understand the aetiology…”
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Brain Structural Signature of Familial Predisposition for Bipolar Disorder: Replicable Evidence For Involvement of the Right Inferior Frontal Gyrus by Hajek, Tomas, Cullis, Jeffrey, Novak, Tomas, Kopecek, Miloslav, Blagdon, Ryan, Propper, Lukas, Stopkova, Pavla, Duffy, Anne, Hoschl, Cyril, Uher, Rudolf, Paus, Tomas, Young, L. Trevor, Alda, Martin

“…Background To translate our knowledge about neuroanatomy of bipolar disorder (BD) into a diagnostic tool, it is necessary to identify the neural signature of…”
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A Fresh Look at Complex I in Microarray Data: Clues to Understanding Disease-Specific Mitochondrial Alterations in Bipolar Disorder by Scola, Gustavo, Kim, Helena Kyunghee, Young, L. Trevor, Andreazza, Ana Cristina

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Three visions of doctoring: a Gadamerian dialogue by Chin-Yee, Benjamin, Messinger, Atara, Young, L. Trevor

“…Medicine in the twenty-first century faces an ‘identity crisis,’ as it grapples with the emergence of various ‘ways of knowing,’ from evidence-based and…”
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Course of Illness, Hippocampal Function, and Hippocampal Volume in Major Depression by MacQueen, Glenda M., Campbell, Stephanie, McEwen, Bruce S., Macdonald, Kathryn, Amano, Shigeko, Joffe, Russell T., Nahmias, Claude, Young, L. Trevor

“…Studies have examined hippocampal function and volume in depressed subjects, but none have systematically compared never-treated first-episode patients with…”
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Association of polygenic risk for bipolar disorder with grey matter structure and white matter integrity in youth by Jiang, Xinyue, Zai, Clement C., Kennedy, Kody G., Zou, Yi, Nikolova, Yuliya S., Felsky, Daniel, Young, L. Trevor, MacIntosh, Bradley J., Goldstein, Benjamin I.

“…There is a gap in knowledge regarding the polygenic underpinnings of brain anomalies observed in youth bipolar disorder (BD). This study examined the…”
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Oxidative damage to RNA but not DNA in the hippocampus of patients with major mental illness by Che, Yi, PhD, Wang, Jun-Feng, MD, PhD, Shao, Li, MD, PhD, Young, L. Trevor, MD, PhD

“…Background Oxidative damage in the central nervous system is increasingly recognized as an important pathological process in many diseases. Previously, our…”
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Oxidation and nitration in dopaminergic areas of the prefrontal cortex from patients with bipolar disorder and schizophrenia by Kim, Helena Kyunghee, BSc, Andreazza, Ana Cristina, Pharm, PhD, Yeung, Pok Yik, BSc, Young, L. Trevor, Isaacs-Trepanier, Cameron, MD, PhD

“…Background Increased oxidative stress is strongly implicated in bipolar disorder (BD), where protein oxidation, lipid peroxidation and oxidative damage to DNA…”
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3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder by Andreazza, Ana Cristina, Pharm D PhD, Kapczinski, Flavio, MD, PhD, Kauer-Sant’Anna, Marcia, MD, PhD, Walz, Julio C., PhD, Bond, David J., MD, Gonçalves, Carlos A., MD, PhD, Young, L. Trevor, MD, PhD, Yatham, Lakshmi N., MBBS

“…Background There has been an increasing interest in the role of oxidative stress in the pathophysiology of bipolar disorder. To explore this further, we…”
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Regulators of mitochondrial complex I activity: A review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder by Duong, Angela, Che, Yi, Ceylan, Deniz, Pinguelo, Arsene, Andreazza, Ana C, Trevor Young, L, Berk, Michael

“…Abstract Phenomenologically, bipolar disorder (BD) is characterized by biphasic increases and decreases in energy. As this is a state-related phenomenon,…”
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Oxidative Stress in Older Patients with Bipolar Disorder by Andreazza, Ana Cristina, Ph.D, Gildengers, Ariel, M.D, Rajji, Tarek K., M.D, Zuzarte, Pedro M.L., M.D, Mulsant, Benoit H., M.D., M.S, Young, L. Trevor, M.D., Ph.D

“…Objective Increases in oxidative stress have been consistently reported in younger patients with bipolar disorder (BD) in postmortem brain and blood samples…”
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Decreased Brain-Derived Neurotrophic Factor in Older Adults with Bipolar Disorder by Soares, Aline T., M.D, Andreazza, Ana C., Ph.D, Rej, Soham, M.D., M.Sc, Rajji, Tarek K., M.D, Gildengers, Ariel G., M.D, Lafer, Beny, M.D., Ph.D, Young, L. Trevor, M.D., Ph.D, Mulsant, Benoit H., M.D., M.S

“…Objectives Decreased levels of brain derived neurotrophic factor (BDNF) have been found in adult patients with bipolar disorder (BD) compared with a comparison…”
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Large positive effect of lithium on prefrontal cortex N -acetylaspartate in patients with bipolar disorder: 2-centre study by Hajek, Tomas, MD, PhD, Bauer, Michael, MD, Pfennig, Andrea, MD, Cullis, Jeffrey, MSc, Ploch, Jana, MSc, O’Donovan, Claire, MD, Bohner, Georg, MD, Klingebiel, Randolf, MD, Young, L. Trevor, MD, PhD, MacQueen, Glenda M., MD, PhD, Alda, Martin, MD

“…Background Neuroprotective effects of lithium (Li) have been well documented in tissue cultures and animal models, whereas human data continue to be limited…”
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