Search Results - "Young, Susan M"

Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters by Strouse, J. Jacob, Ivnitski-Steele, Irena, Waller, Anna, Young, Susan M., Perez, Dominique, Evangelisti, Annette M., Ursu, Oleg, Bologa, Cristian G., Carter, Mark B., Salas, Virginia M., Tegos, George, Larson, Richard S., Oprea, Tudor I., Edwards, Bruce S., Sklar, Larry A.

“…ATP binding cassette (ABC) transmembrane efflux pumps such as P-glycoprotein (ABCB1), multidrug resistance protein 1 (ABCC1), and breast cancer resistance…”
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An automated high-throughput cell-based multiplexed flow cytometry assay to identify novel compounds to target Candida albicans virulence-related proteins by Bernardo, Stella M, Allen, Christopher P, Waller, Anna, Young, Susan M, Oprea, Tudor, Sklar, Larry A, Lee, Samuel A

“…Although three major classes of systemic antifungal agents are clinically available, each is characterized by important limitations. Thus, there has been…”
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High-throughput flow cytometry bead-based multiplex assay for identification of Rho GTPase inhibitors by Surviladze, Zurab, Young, Susan M, Sklar, Larry A

“…Rho family GTPases and their effector proteins regulate a wide range of cell signaling pathways. In normal physiological conditions, their activity is tightly…”
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Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry by Johnson, Rebecca M., Allen, Chris, Melman, Sandra D., Waller, Anna, Young, Susan M., Sklar, Larry A., Parra, Karlett J.

“…Fluorescence intensity of the pH-sensitive carboxyfluorescein derivative 2,7-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) was monitored by…”
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Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists by Edwards, Bruce S, Bologa, Cristian, Young, Susan M, Balakin, Konstantin V, Prossnitz, Eric R, Savchuck, Nikolay P, Sklar, Larry A, Oprea, Tudor I

“…The formylpeptide receptor (FPR) family of G-protein-coupled receptors contributes to the localization and activation of tissue-damaging leukocytes at sites of…”
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Virtual and biomolecular screening converge on a selective agonist for GPR30 by Oprea, Tudor I, Prossnitz, Eric R, Bologa, Cristian G, Revankar, Chetana M, Young, Susan M, Edwards, Bruce S, Arterburn, Jeffrey B, Kiselyov, Alexander S, Parker, Matthew A, Tkachenko, Sergey E, Savchuck, Nikolay P, Sklar, Larry A

“…Estrogen is a hormone critical in the development, normal physiology and pathophysiology of numerous human tissues. The effects of estrogen have traditionally…”
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An Analysis of Accounting Frauds and the Timing of Analyst Coverage Decisions and Recommendation Revisions: Evidence from the US by Young, Susan M., Peng, Emma Y.

“…This paper provides a comprehensive exploration of the types of accounting fraud committed by firms over the period 1995–2009. Using detailed data from US SEC…”
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Drug repurposing from an academic perspective by Oprea, Tudor I, Bauman, Julie E, Bologa, Cristian G, Buranda, Tione, Chigaev, Alexandre, Edwards, Bruce S, Jarvik, Jonathan W, Gresham, Hattie D, Haynes, Mark K, Hjelle, Brian, Hromas, Robert, Hudson, Laurie, Mackenzie, Debra A, Muller, Carolyn Y, Reed, John C, Simons, Peter C, Smagley, Yelena, Strouse, Juan, Surviladze, Zurab, Thompson, Todd, Ursu, Oleg, Waller, Anna, Wandinger-Ness, Angela, Winter, Stuart S, Wu, Yang, Young, Susan M, Larson, Richard S, Willman, Cheryl, Sklar, Larry A

“…Academia and small business research units are poised to play an increasing role in drug discovery, with drug repurposing as one of the major areas of…”
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Determinants of Analysts' Dropped Coverage Decision: The Role of Analyst Incentives, Experience, and Accounting Fundamentals by Shon, John, Young, Susan M.

“…:  After controlling for economic performance (i.e., stock returns), we find that several proxies for analyst incentives as well as accounting‐based…”
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Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries by Pinilla, Clemencia, Edwards, Bruce S, Appel, Jon R, Yates-Gibbins, Tina, Giulianotti, Marc A, Medina-Franco, Jose L, Young, Susan M, Santos, Radleigh G, Sklar, Larry A, Houghten, Richard A

“…The formylpeptide receptor (FPR1) and formylpeptide-like 1 receptor (FPR2) are G protein-coupled receptors that are linked to acute inflammatory responses,…”
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Simultaneous in vitro molecular screening of protein-peptide interactions by flow cytometry, using six Bcl-2 family proteins as examples by Simons, Peter C, Young, Susan M, Carter, Mark B, Waller, Anna, Zhai, Dayong, Reed, John C, Edwards, Bruce S, Sklar, Larry A

“…The B-cell lymphoma-2 (Bcl-2) family contains six antiapoptotic members, each with a hydrophobic pocket in which Bcl-2 homology region 3 (BH3) helices bind…”
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High-content screening: flow cytometry analysis by Edwards, Bruce S, Young, Susan M, Ivnitsky-Steele, Irena, Ye, Richard D, Prossnitz, Eric R, Sklar, Larry A

“…The HyperCyt high-throughput (HT) flow cytometry sampling platform uses a peristaltic pump, in combination with an autosampler, and a novel approach to data…”
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Identification of a Small Molecule Yeast TORC1 Inhibitor with a Multiplex Screen Based on Flow Cytometry by Chen, Jun, Young, Susan M, Allen, Chris, Seeber, Andrew, Péli-Gulli, Marie-Pierre, Panchaud, Nicolas, Waller, Anna, Ursu, Oleg, Yao, Tuanli, Golden, Jennifer E, Strouse, J. Jacob, Carter, Mark B, Kang, Huining, Bologa, Cristian G, Foutz, Terry D, Edwards, Bruce S, Peterson, Blake R, Aubé, Jeffrey, Werner-Washburne, Margaret, Loewith, Robbie J, De Virgilio, Claudio, Sklar, Larry A

“…TOR (target of rapamycin) is a serine/threonine kinase, evolutionarily conserved from yeast to human, which functions as a fundamental controller of cell…”
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Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes by Young, Susan M, Bologa, Cristian M, Fara, Dan, Bryant, Bj K, Strouse, Juan Jacob, Arterburn, Jeffrey B, Ye, Richard D, Oprea, Tudor I, Prossnitz, Eric R, Sklar, Larry A, Edwards, Bruce S

“…Of recent, clinical interest have been two related human G-protein coupled receptors: formylpeptide receptor (FPR), linked to antibacterial inflammation and…”
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High-involvement work practices and analysts' forecasts of corporate earnings by Benson, George S., Young, Susan M., Lawler III, Edward E.

“…Research has shown that high‐involvement work practices are positively related to corporate financial performance. However, it is unknown if investors are able…”
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High-throughput screen for the chemical inhibitors of antiapoptotic bcl-2 family proteins by multiplex flow cytometry by Curpan, Ramona F, Simons, Peter C, Zhai, Dayong, Young, Susan M, Carter, Mark B, Bologa, Cristian G, Oprea, Tudor I, Satterthwait, Arnold C, Reed, John C, Edwards, Bruce S, Sklar, Larry A

“…The human Bcl-2 family includes six antiapoptotic members (Bcl-2, Bcl-B, Bcl-W, Bcl-X(L), Bfl-1, and Mcl-1) and many proapoptotic members, wherein a balance…”
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Fraud Type and Auditor Litigation: An Analysis of SEC Accounting and Auditing Enforcement Releases by Bonner, Sarah E., Palmrose, Zoe-Vonna, Young, Susan M.

“…This study examines whether certain types of financial reporting fraud result in a higher likelihood of litigation against independent auditors. We expect that…”
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The Effect of Perceived Uncertainty on Analysts' Recommendations and Earnings Forecasts by Young, Susan M

“…Prior literature has found that as uncertainty in a firms information environment increases, optimism increases in equity analysts' earnings forecasts. The…”
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Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform by Edwards, Bruce S, Young, Susan M, Oprea, Tudor I, Bologa, Cristian G, Prossnitz, Eric R, Sklar, Larry A

“…The formylpeptide receptor (FPR) family of G protein-coupled receptors contributes to the localization and activation of tissue-damaging leukocytes at sites of…”
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Sophistication-Related Differences in Investors' Models of the Relative Accuracy of Analysts' Forecast Revisions by Bonner, Sarah E., Walther, Beverly R., Young, Susan M.

“…The accuracy of sell-side analysts' forecast revisions is related to a number of factors, including characteristics of the analyst and the age of the forecast…”
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