Search Results - "Young, Samuel M."

Centering on synaptic vesicle release by Young, Jr, Samuel M

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Triple Function of Synaptotagmin 7 Ensures Efficiency of High-Frequency Transmission at Central GABAergic Synapses by Chen, Chong, Satterfield, Rachel, Young, Samuel M., Jonas, Peter

“…Synaptotagmin 7 (Syt7) is thought to be a Ca2+ sensor that mediates asynchronous transmitter release and facilitation at synapses. However, Syt7 is strongly…”
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Presynaptic Mitochondria Volume and Abundance Increase during Development of a High-Fidelity Synapse by Thomas, Connon I, Keine, Christian, Okayama, Satoko, Satterfield, Rachel, Musgrove, Morgan, Guerrero-Given, Debbie, Kamasawa, Naomi, Young, Jr, Samuel M

“…The calyx of Held, a large glutamatergic presynaptic terminal in the auditory brainstem undergoes developmental changes to support the high action-potential…”
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CaV2.1 α1 subunit motifs that control presynaptic CaV2.1 subtype abundance are distinct from CaV2.1 preference by Li, Jianing, Veeraraghavan, Priyadharishini, Young, Samuel M.

“…Presynaptic voltage‐gated Ca2+ channel (CaV) subtype abundance at mammalian synapses regulates synaptic transmission in health and disease. In the mammalian…”
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Synaptotagmin Has an Essential Function in Synaptic Vesicle Positioning for Synchronous Release in Addition to Its Role as a Calcium Sensor by Young, Samuel M., Neher, Erwin

“…A multitude of synaptic proteins interact at the active zones of nerve terminals to achieve the high temporal precision of neurotransmitter release in…”
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Synaptotagmin 2 Is the Fast Ca2+ Sensor at a Central Inhibitory Synapse by Chen, Chong, Arai, Itaru, Satterfield, Rachel, Young, Samuel M., Jonas, Peter

“…GABAergic synapses in brain circuits generate inhibitory output signals with submillisecond latency and temporal precision. Whether the molecular identity of…”
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Development and evaluation of helper dependent adenoviral vectors for inner ear gene delivery by Tarabichi, Osama, Correa, Tatiana, Kul, Emre, Phillips, Stacia, Darkazanly, Bahaa, Young, Samuel M., Hansen, Marlan R.

“…•HdAd is a versatile viral vector with large carrying capacity that can overcome size limitations of adeno-associated virus vectors.HdAd5 transduces multiple…”
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Ca2+ channel to synaptic vesicle distance accounts for the readily releasable pool kinetics at a functionally mature auditory synapse by Chen, Zuxin, Das, Brati, Nakamura, Yukihiro, DiGregorio, David A, Young, Jr, Samuel M

“…Precise regulation of synaptic vesicle (SV) release at the calyx of Held is critical for auditory processing. At the prehearing calyx of Held, synchronous and…”
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The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse by Chen, Zuxin, Cooper, Benjamin, Kalla, Stefan, Varoqueaux, Frederique, Young, Jr, Samuel M

“…The Munc13 gene family encodes molecules located at the synaptic active zone that regulate the reliability of synapses to encode information over a wide range…”
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Orphan receptor GPR158 controls stress-induced depression by Sutton, Laurie P, Orlandi, Cesare, Song, Chenghui, Oh, Won Chan, Muntean, Brian S, Xie, Keqiang, Filippini, Alice, Xie, Xiangyang, Satterfield, Rachel, Yaeger, Jazmine D W, Renner, Kenneth J, Young, Jr, Samuel M, Xu, Baoji, Kwon, Hyungbae, Martemyanov, Kirill A

“…Stress can be a motivational force for decisive action and adapting to novel environment; whereas, exposure to chronic stress contributes to the development of…”
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CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse by Dong, Wei, Radulovic, Tamara, Goral, R. Oliver, Thomas, Connon, Suarez Montesinos, Monica, Guerrero-Given, Debbie, Hagiwara, Akari, Putzke, Travis, Hida, Yamato, Abe, Manabu, Sakimura, Kenji, Kamasawa, Naomi, Ohtsuka, Toshihisa, Young, Samuel M.

“…In the presynaptic terminal, the magnitude and location of Ca2+ entry through voltage-gated Ca2+ channels (VGCCs) regulate the efficacy of neurotransmitter…”
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Presynaptic voltage-gated calcium channels in the auditory brainstem by Young, Samuel M., Veeraraghavan, Priyadharishini

“…Sound information encoding within the initial synapses in the auditory brainstem requires reliable and precise synaptic transmission in response to rapid and…”
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Presynaptic development is controlled by the core active zone proteins CAST/ELKS by Radulovic, Tamara, Dong, Wei, Goral, R. Oliver, Thomas, Connon I., Veeraraghavan, Priyadharishini, Montesinos, Monica Suarez, Guerrero‐Given, Debbie, Goff, Kevin, Lübbert, Matthias, Kamasawa, Naomi, Ohtsuka, Toshihisa, Young, Samuel M.

“…Key points CAST/ELKS are positive regulators of presynaptic growth and are suppressors of active zone expansion at the developing mouse calyx of Held…”
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A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2 by Dusonchet, Julien, Kochubey, Olexiy, Stafa, Klodjan, Young, Jr, Samuel M, Zufferey, Romain, Moore, Darren J, Schneider, Bernard L, Aebischer, Patrick

“…The G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene is the most common genetic cause of Parkinson's disease (PD), accounting for a significant…”
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Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse by Montesinos, Mónica S., Dong, Wei, Goff, Kevin, Das, Brati, Guerrero-Given, Debbie, Schmalzigaug, Robert, Premont, Richard T., Satterfield, Rachel, Kamasawa, Naomi, Young, Samuel M.

“…A cytomatrix of proteins at the presynaptic active zone (CAZ) controls the strength and speed of neurotransmitter release at synapses in response to action…”
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A novel region in the CaV2.1 α1 subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone by Lübbert, Matthias, Goral, R Oliver, Satterfield, Rachel, Putzke, Travis, van den Maagdenberg, Arn MJM, Kamasawa, Naomi, Young, Samuel M

“…In central nervous system (CNS) synapses, action potential-evoked neurotransmitter release is principally mediated by CaV2.1 calcium channels (CaV2.1) and is…”
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Ca V 2.1 α 1 Subunit Expression Regulates Presynaptic Ca V 2.1 Abundance and Synaptic Strength at a Central Synapse by Lübbert, Matthias, Goral, R Oliver, Keine, Christian, Thomas, Connon, Guerrero-Given, Debbie, Putzke, Travis, Satterfield, Rachel, Kamasawa, Naomi, Young, Jr, Samuel M

“…The abundance of presynaptic Ca 2 voltage-gated Ca channels (Ca 2) at mammalian active zones (AZs) regulates the efficacy of synaptic transmission. It is…”
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Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development by Kawabe, Hiroshi, Neeb, Antje, Dimova, Kalina, Young, Samuel M., Takeda, Michiko, Katsurabayashi, Shutaro, Mitkovski, Miso, Malakhova, Oxana A., Zhang, Dong-Er, Umikawa, Masato, Kariya, Ken-ichi, Goebbels, Sandra, Nave, Klaus-Armin, Rosenmund, Christian, Jahn, Olaf, Rhee, JeongSeop, Brose, Nils

“…Nedd4-1 is a “ neuronal precursor cell expressed and developmentally downregulated protein” and among the most abundant E3 ubiquitin ligases in mammalian…”
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Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming by Keine, Christian, Al-Yaari, Mohammed, Radulovic, Tamara, Thomas, Connon I, Valino Ramos, Paula, Guerrero-Given, Debbie, Ranjan, Mrinalini, Taschenberger, Holger, Kamasawa, Naomi, Young, Jr, Samuel M

“…Synapses contain a limited number of synaptic vesicles (SVs) that are released in response to action potentials (APs). Therefore, sustaining synaptic…”
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Helper-Dependent Adenoviral Vectors and Their Use for Neuroscience Applications by Montesinos, Mónica S, Satterfield, Rachel, Young, Jr, Samuel M

“…Neuroscience research has been revolutionized by the use of recombinant viral vector technology from the basic, preclinical and clinical levels. Currently,…”
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