Search Results - "Young, S. N."

RIPK1- and RIPK3-induced cell death mode is determined by target availability by Cook, W D, Moujalled, D M, Ralph, T J, Lock, P, Young, S N, Murphy, J M, Vaux, D L

“…Both receptor-interacting protein kinase 1 (RIPK1) and RIPK3 can signal cell death following death receptor ligation. To study the requirements for…”
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Evolutionary divergence of the necroptosis effector MLKL by Tanzer, M C, Matti, I, Hildebrand, J M, Young, S N, Wardak, A, Tripaydonis, A, Petrie, E J, Mildenhall, A L, Vaux, D L, Vince, J E, Czabotar, P E, Silke, J, Murphy, J M

“…The pseudokinase, MLKL (mixed-lineage kinase domain-like), is the most terminal obligatory component of the necroptosis cell death pathway known…”
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Clinical utility of gene panel-based testing for hereditary myelodysplastic syndrome/acute leukemia predisposition syndromes by Guidugli, L, Johnson, A K, Alkorta-Aranburu, G, Nelakuditi, V, Arndt, K, Churpek, J E, Godley, L A, Townsley, D, Young, N S, Fitzpatrick, C, del Gaudio, D, Das, S, Li, Z

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Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia by Calado, R T, Cooper, J N, Padilla-Nash, H M, Sloand, E M, Wu, C O, Scheinberg, P, Ried, T, Young, N S

“…In cell and animal models, telomere erosion promotes chromosomal instability via breakage-fusion-bridge cycles, contributing to the early stages of…”
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Anxiety, emotional security and the interpersonal behavior of individuals with social anxiety disorder by Russell, J J, Moskowitz, D S, Zuroff, D C, Bleau, P, Pinard, G, Young, S N

“…Interpersonal functioning is central to social anxiety disorder (SAD). Empirical examinations of interpersonal behaviors in individuals with SAD have…”
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Differences between Males and Females in Rates of Serotonin Synthesis in Human Brain by Nishizawa, S., Benkelfat, C., Young, S. N., Leyton, M., Mzengeza, S., De Montigny, C., Blier, P., Diksic, M.

“…Rates of serotonin synthesis were measured in the human brain using positron emission tomography. The sensitivity of the method is indicated by the fact that…”
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Exposure to bright light is associated with positive social interaction and good mood over short time periods: A naturalistic study in mildly seasonal people by aan het Rot, M, Moskowitz, D.S, Young, S.N

“…Abstract Bright light is used to treat winter depression and might also have positive effects on mood in some healthy individuals. We examined possible links…”
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Fas Antigen Expression on CD34+ Human Marrow Cells Is Induced by Interferon γ and Tumor Necrosis Factor α and Potentiates Cytokine-Mediated Hematopoietic Suppression In Vitro by Maciejewski, Jaroslaw, Selleri, Carmine, Anderson, Stacie, Young, Neal S.

“…Activation of Fas antigen, a cell surface receptor molecule, by its ligand results in transduction of a signal for cell death. The Fas system has been…”
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Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction by EMMONS, R. V. B, REID, D. M, COHEN, R. L, MENG, G, YOUNG, N. S, DUNBAR, C. E, SHULMAN, N. R

“…Thrombopoietin (TPO), the ligand for c-mpl, stimulates proliferation of committed megakaryocytic progenitors and induces maturation of megakaryocytes. To…”
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Effects of L‐histidine depletion and L‐tyrosine/L‐phenylalanine depletion on sensory and motor processes in healthy volunteers by Van Ruitenbeek, P, Sambeth, A, Vermeeren, A, Young, SN, Riedel, WJ

“…Background and purpose:  Animal studies show that histamine plays a role in cognitive functioning and that histamine H3‐receptor antagonists, which increase…”
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Large granular lymphocyte (LGL)-like clonal expansions in paroxysmal nocturnal hemoglobinuria (PNH) patients by RISITANO, A. M, MACIEJEWSKI, J. P, MURANSKI, P, WLODARSKI, M, O'KEEFE, C, SLOAND, E. M, YOUNG, N. S

“…In paroxysmal nocturnal hemoglobinuria (PNH), clonal expansion of glycosylphosphatidylinositol-anchored proteins (GPI-AP)-deficient cells leads to a syndrome…”
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Erosion of telomeric single-stranded overhang in patients with aplastic anaemia carrying telomerase complex mutations by Calado, R. T., Regal, J. A., Kajigaya, S., Young, N. S.

“…Background  Loss‐of‐function mutations in telomerase complex genes reduce telomerase activity and shorten overall telomere length in leucocytes, and they can…”
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Telomere length in leukocyte subpopulations of patients with aplastic anemia by BRÜMMENDORF, Tim H, MACIEJEWSKI, Jaroslaw P, MAK, Jennifer, YOUNG, Neal S, LANSDORP, Peter M

“…In most human cells, the average length of telomere repeats at the ends of chromosomes provides indirect information about their mitotic history. To study the…”
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Effects on Mood of Acute Phenylalanine/Tyrosine Depletion in Healthy Women by Leyton, M., Young, S.N., Pihl, R.O., Etezadi, S., Lauze, C., Blier, P., Baker, G.B., Benkelfat, C.

“…Catecholamines have been implicated in the etiology and pathophysiology of mood and anxiety disorders. In the present study, we investigated the effects of…”
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Interferon-γ Constitutively Expressed in the Stromal Microenvironment of Human Marrow Cultures Mediates Potent Hematopoietic Inhibition by Selleri, Carmine, Maciejewski, Jaroslaw P., Sato, Tadatsugu, Young, Neal S.

“…Clinical and laboratory studies have suggested involvement of interferon-γ (IFN-γ) in the pathophysiology of aplastic anemia. T cells from aplastic anemia (AA)…”
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Implications of impulsive and affective symptoms for serotonin function in bulimia nervosa by Steiger, H, Young, S N, Kin, N M, Koerner, N, Israel, M, Lageix, P, Paris, J

“…Bulimic, impulsive and depressive syndromes have all been associated with abnormalities in brain serotonin (5-hydroxytryptamine; 5-HT) mechanisms. We had 26…”
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Patient‐specific transfusion‐related acute lung injury by Muniz, M., Sheldon, S., Schuller, R. M., Young, N. S., Klein, H. G., Leitman, S. F., Stroncek, D. F.

“…Transfusion‐related acute lung injury (TRALI) is one of the leading causes of transfusion‐associated mortality. The inadvertent transfusion of neutrophil…”
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Increasing blood oxygen increases an index of 5-HT synthesis in human brain as measured using α-[ 11C]methyl- l-tryptophan and positron emission tomography by Nishikawa, M., Kumakura, Y., Young, S.N., Fiset, P., Vogelzangs, N., Leyton, M., Benkelfat, C., Diksic, M.

“…The main objective of this investigation was to test the hypothesis that brain serotonin (5-HT) synthesis, as measured by trapping of α-[ 11C]methyl-…”
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Methodology and interpretation of acute tryptophan depletion studies by Young, S. N.

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Paroxysmal nocturnal hemoglobinuria cells in Patients with bone marrow failure syndromes by DUNN, D. E, TANAWATTANACHAROEN, P, BOCCUNI, P, NAGAKURA, S, GREEN, S. W, KIRBY, M. R, ANIL KUMAR, M. S, ROSENFELD, S, YOUNG, N. S

“…Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic stem-cell disorder in which the affected cells are deficient in…”
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