Search Results - "Young, Roger C"

Linking myometrial physiology to intrauterine pressure; how tissue-level contractions create uterine contractions of labor by Young, Roger C, Barendse, Peter

“…The mechanisms used to coordinate uterine contractions are not known. We develop a new model based on the proposal that there is a maximum distance to which…”
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Myocytes, Myometrium, and Uterine Contractions by YOUNG, ROGER C.

“…:  The pregnant uterus is unique because of the dramatic functional changes that occur in the peripartum period. To promote the concept that we have a…”
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Uterine overdistention induces preterm labor mediated by inflammation: observations in pregnant women and nonhuman primates by Adams Waldorf, Kristina M., MD, Singh, Natasha, MBBS, MRCOG, BSCCP, Mohan, Aarthi R., MD, PhD, Young, Roger C., MD, PhD, Ngo, Lisa, BS, Das, Ananya, MSc, Tsai, Jesse, BS, Bansal, Aasthaa, PhD, Paolella, Louis, BS, Herbert, Bronwen R., BSc, PhD, Sooranna, Suren R., PhD, Gough, G. Michael, MSc, Astley, Cliff, MS, Vogel, Keith, DVM, Baldessari, Audrey E., DVM, Bammler, Theodor K., PhD, MacDonald, James, MSc, Gravett, Michael G., MD, Rajagopal, Lakshmi, PhD, Johnson, Mark R., MD, PhD

“…Objective Uterine overdistention is thought to induce preterm labor in women with twin and multiple pregnancies, but the pathophysiology remains unclear. We…”
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Why the heart is like an orchestra and the uterus is like a soccer crowd by Smith, Roger, MD, PhD, Imtiaz, Mohammad, BSc (EE), PhD, Banney, David, MB, BS, BMus (Hons), Paul, Jonathan W., BSc (Biotech)(Hons), PhD, Young, Roger C., MD, PhD

“…The human uterus has no pacemaker or motor innervation, yet develops rhythmic, powerful contractions that increase intrauterine pressure to dilate the cervix…”
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Allo- and xeno-reassembly of human and rat myometrium from cells and scaffolds by Young, Roger C, Goloman, Gabriela

“…Neo-myometrium was created by culturing isolated myocytes into decellularized rat and human myometrial scaffolds. The dual purpose of the uterus is to…”
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Postpartum Hemorrhage Trends and Outcomes in the United States, 2000-2019 by Young, Roger C

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Phasic oscillations of extracellular potassium (K(o)) in pregnant rat myometrium by Young, Roger C, Goloman, Gabriela

“…K-sensitive microelectrodes were used to measure K(+) within the extracellular space (K(o)) of pregnant rat myometrium. Contractile activity was monitored by…”
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Mechanotransduction mechanisms for coordinating uterine contractions in human labor by Young, Roger C

“…This review presents evolving concepts of how the human uterus contracts in pregnancy, with emphasis on the mechanisms of long-distance signaling. Action…”
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Machine Learning and Statistical Models to Predict Postpartum Hemorrhage by Young, Roger C.

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Evaluating aminophylline and progesterone combination treatment to modulate contractility and labor‐related proteins in pregnant human myometrial tissues by Lai, Pei F., Young, Roger C., Tribe, Rachel M., Johnson, Mark R.

“…Progesterone (P4) and cyclic adenosine monophosphate (cAMP) are regarded as pro‐quiescent factors that suppress uterine contractions during pregnancy. We…”
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Synchronization of regional contractions of human labor; direct effects of region size and tissue excitability by Young, Roger C

“…Abstract The mechanisms used to coordinate organ-level contractions of human labor are not universally accepted. We previously proposed a dual mechanism, where…”
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Monitoring uterine contractions during labor: current challenges and future directions by Young, Roger C., Marinescu, Ponnila S., Seligman, Neil S.

“…Organ-level models are used to describe how cellular and tissue-level contractions coalesce into clinically observable uterine contractions. More importantly,…”
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Calcium-activated chloride currents prolongs the duration of contractions in pregnant rat myometrial tissue by Young, Roger C, Bemis, Adam

“…We investigated the importance of pharmacologically blocking calcium-activated chloride (I(Cl(Ca))) and L-type calcium currents on isometric contractions of…”
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Introduction to confocal microscopy by Nwaneshiudu, Adaobi, Kuschal, Christiane, Sakamoto, Fernanda H, Anderson, R Rox, Schwarzenberger, Kathryn, Young, Roger C

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Mid-trimester uterine electromyography in patients with a short cervix by Marinescu, Ponnila S., Young, Roger C., Miller, Lauren A., Llop, Jesse R., Pressman, Eva K., Seligman, Neil S.

“…Preterm birth is the largest single cause of infant death in the United States. A cervical length of <2.5 cm, measured in the mid-trimester, has been shown to…”
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Assessing the Potency of the Novel Tocolytics 2-APB, Glycyl-H-1152, and HC-067047 in Pregnant Human Myometrium by Hossain, Md Reduanul, Tolosa, Jorge M, Young, Roger C, Smith, Roger, Paul, Jonathan W

“…The intracellular signaling pathways that regulate myometrial contractions can be targeted by drugs for tocolysis. The agents, 2-APB, glycyl-H-1152, and…”
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Uterine Bioelectrical Activity in Pregnant Women With a Short Cervix in the Mid-Trimester [19O] by Marinescu, Ponnila S, Miller, Lauren Anne, Young, Roger C, Hern, Braxton, Pressman, Eva K, Seligman, Neil Stuart

“…INTRODUCTION:Mechanisms of mid-trimester cervical shortening (<2.5cm) are unclear, and it is unknown if subclinical uterine activity plays a causative role…”
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3D Cell Culturing and Possibilities for Myometrial Tissue Engineering by Heidari Kani, Minoo, Chan, Eng-Cheng, Young, Roger C., Butler, Trent, Smith, Roger, Paul, Jonathan W.

“…Research insights into uterine function and the mechanisms of labour have been hindered by the lack of suitable animal and cellular models. The use of…”
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Mechanotransduction in rat myometrium: coordination of contractions of electrically and chemically isolated tissues by Young, Roger C, Goloman, Gabriela

“…The generally accepted mechanism for global uterine coordination is propagation of electrical activity. Mechanotransduction mechanisms were briefly considered…”
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Oxytocin-induced desensitization of the oxytocin receptor by Robinson, Christopher, Schumann, Ralph, Zhang, Peisheng, Young, Roger C.

“…Objective: The purpose of this study was to characterize the oxytocin-induced desensitization of oxytocin-stimulated rises of intracellular calcium in cultured…”
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