Search Results - "Young, Rodrigo M"
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In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains
Published in Developmental biology (15-06-2012)“…The creation of molecular tools able to unravel in vivo spatiotemporal activation of specific cell signaling events during cell migration, differentiation and…”
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Tcf7l2 Is Required for Left-Right Asymmetric Differentiation of Habenular Neurons
Published in Current biology (06-10-2014)“…Although left-right asymmetries are common features of nervous systems, their developmental bases are largely unknown. In the zebrafish epithalamus, dorsal…”
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Transcription factor 7-like 1 is involved in hypothalamo–pituitary axis development in mice and humans
Published in Proceedings of the National Academy of Sciences - PNAS (02-02-2016)“…Aberrant embryonic development of the hypothalamus and/or pituitary gland in humans results in congenital hypopituitarism (CH). Transcription factor 7-like 1…”
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Developmentally regulated Tcf7l2 splice variants mediate transcriptional repressor functions during eye formation
Published in eLife (12-12-2019)“…Tcf7l2 mediates Wnt/β-Catenin signalling during development and is implicated in cancer and type-2 diabetes. The mechanisms by which Tcf7l2 and Wnt/β-Catenin…”
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Smartphone screen testing, a novel pre-diagnostic method to identify SARS-CoV-2 infectious individuals
Published in eLife (22-06-2021)“…The COVID-19 pandemic will likely take years to control globally, and constant epidemic surveillance will be required to limit the spread of SARS-CoV-2,…”
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Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification
Published in eLife (19-02-2019)“…The vertebrate eye originates from the eye field, a domain of cells specified by a small number of transcription factors. In this study, we show that Tcf7l1a…”
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Collaborative Research and Development of a Novel, Patient-Centered Digital Platform (MyEyeSite) for Rare Inherited Retinal Disease Data: Acceptability and Feasibility Study
Published in JMIR formative research (31-01-2022)“…Inherited retinal diseases (IRDs) are a leading cause of blindness in children and working age adults in the United Kingdom and other countries, with an…”
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Tissue-Specific Requirement for the GINS Complex During Zebrafish Development
Published in Frontiers in cell and developmental biology (28-05-2020)“…Efficient and accurate DNA replication is particularly critical in stem and progenitor cells for successful proliferation and survival. The replisome, an…”
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Transcriptome profiling of zebrafish optic fissure fusion
Published in Scientific reports (07-02-2019)“…Incomplete fusion of the optic fissure leads to ocular coloboma, a congenital eye defect that affects up to 7.5 per 10,000 births and accounts for up to 10…”
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Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain
Published in Science (American Association for the Advancement of Science) (03-05-2024)“…Neurons on the left and right sides of the nervous system often show asymmetric properties, but how such differences arise is poorly understood. Genetic…”
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Expanding the phenotypic spectrum consequent upon de novo WDR37 missense variants
Published in Clinical genetics (01-08-2020)“…Structural eye disorders are increasingly recognised as having a genetic basis, although current genetic testing is limited in its success. De novo missense…”
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De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies
Published in American journal of human genetics (05-09-2019)“…The identification of genetic variants implicated in human developmental disorders has been revolutionized by second-generation sequencing combined with…”
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Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish
Published in Development (Cambridge) (01-04-2016)“…Maintaining neurogenesis in growing tissues requires a tight balance between progenitor cell proliferation and differentiation. In the zebrafish retina,…”
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Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development
Published in Development (Cambridge) (15-09-2011)“…During tissue morphogenesis and differentiation, cells must self-renew while contemporaneously generating daughters that contribute to the growing tissue. How…”
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HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain
Published in Development (Cambridge) (15-11-2011)“…The Wnt/β-catenin pathway plays an essential role during regionalisation of the vertebrate neural plate and its inhibition in the most anterior neural ectoderm…”
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Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis
Published in Genetics in medicine (01-05-2022)“…Ocular coloboma arises from genetic or environmental perturbations that inhibit optic fissure (OF) fusion during early eye development. Despite high genetic…”
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Early Stages of Zebrafish Eye Formation Require the Coordinated Activity of Wnt11, Fz5, and the Wnt/β-Catenin Pathway
Published in Neuron (Cambridge, Mass.) (07-07-2005)“…During regional patterning of the anterior neural plate, a medially positioned domain of cells is specified to adopt retinal identity. These eye field cells…”
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De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies
Published in American journal of human genetics (05-09-2019)Get full text
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Expression and splice variant analysis of the zebrafish tcf4 transcription factor
Published in Mechanisms of development (01-09-2002)“…Wnt signalling has been implicated in antero-posterior patterning of the vertebrate embryonic body axis and in a number of other developmental processes. One…”
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Zebrafish yolk‐specific not really started (nrs) gene is a vertebrate homolog of the Drosophila spinster gene and is essential for embryogenesis
Published in Developmental dynamics (01-03-2002)“…By using retroviral insertional mutagenesis in zebrafish, we have identified a recessive lethal mutation in the not really started (nrs) gene. The nrs mutation…”
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