Search Results - "Young, Philip J"

A Mechanism of Release of Calreticulin from Cells During Apoptosis by Tarr, Joanna M., Young, Philip J., Morse, Robert, Shaw, Debra J., Haigh, Richard, Petrov, Peter G., Johnson, Steven J., Winyard, Paul G., Eggleton, Paul

“…Calreticulin (CRT) is an endoplasmic reticulum (ER) chaperone responsible for glycoprotein folding and Ca2+ homeostasis. CRT also has extracellular functions,…”
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Electronic and Spectroscopic Properties of Avobenzone Derivatives Attached to Mo2 Quadruple Bonds: Suppression of the Photochemical Enol-to-Keto Transformation by Chisholm, Malcolm H, Durr, Christopher B, Gustafson, Terry L, Kender, William T, Spilker, Thomas F, Young, Philip J

“…From the reactions between Mo2(T i PB)4, where T i PB is 2,4,6-triisopropylbenzoate, and 2 equiv of the acids 4-formylbenzoic acid, HBzald;…”
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Newborn genetic screening for spinal muscular atrophy in the UK: The views of the general population by Boardman, Felicity K., Sadler, Chloe, Young, Philip J.

“…Background Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder and a leading genetic cause of infant death worldwide. However, there is no…”
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Monte Carlo simulation of the Spearman-Kaerber TCID50 by Wulff, Niels H, Tzatzaris, Maria, Young, Philip J

“…In the biological sciences the TCID50 (median tissue culture infective dose) assay is often used to determine the strength of a virus. When the so-called…”
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Analysis of SMN-neurite granules: Core Cajal body components are absent from SMN-cytoplasmic complexes by Todd, Adrian G., Morse, Robert, Shaw, Debra J., Stebbings, Howard, Young, Philip J.

“…Childhood spinal muscular atrophy (SMA) is caused by a reduction in survival motor neuron (SMN) protein. SMN is a ubiquitously expressed house keeping protein…”
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Identification of Cytochrome P-450 Isoforms Responsible for cis-Tramadol Metabolism in Human Liver Microsomes by SUBRAHMANYAM, Vangala, RENWICK, Anthony B, WALTERS, David G, YOUNG, Philip J, PRICE, Roger J, TONELLI, Alfred P, LAKE, Brian G

“…The metabolism of cis -tramadol has been studied in human liver microsomes and in cDNA-expressed human cytochrome P-450 (CYP) isoforms. Human liver microsomes…”
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Social and cultural influences on genetic screening programme acceptability: A mixed‐methods study of the views of adults, carriers, and family members living with thalassemia in the UK by Boardman, Felicity K., Clark, Corinna, Jungkurth, Elsita, Young, Philip J.

“…As population‐level carrier screening panels for reprogenetic information emerge globally, conditions to be included, and the timing of implementation is…”
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A Direct Interaction between the Survival Motor Neuron Protein and p53 and Its Relationship to Spinal Muscular Atrophy by Young, Philip J., Day, Patricia M., Zhou, Jianhua, Androphy, Elliot J., Morris, Glenn E., Lorson, Christian L.

“…Mutations in the SMN1(survival motor neuron1) gene cause spinal muscular atrophy (SMA). We now show that SMN protein, the SMN1 gene product, interacts directly…”
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Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic death by Kepp, Oliver, Gdoura, Abdelaziz, Martins, Isabelle, Panaretakis, Theocharis, Schlemmer, Frederic, Tesniere, Antoine, Fimia, Gian Maria, Ciccosanti, Fabiola, Burgevin, Anne, Piacentini, Mauro, Eggleton, Paul, Young, Philip J., Zitvogel, Laurence, van Endert, Peter, Kroemer, Guido

“…In response to immunogenic cell death inducers, calreticulin (CRT) translocates from its orthotopic localization in the lumen of the endoplasmic reticulum (ER)…”
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Identification of a tripartite import signal in the Ewing Sarcoma protein (EWS) by Shaw, Debra J., Morse, Robert, Todd, Adrian G., Eggleton, Paul, Lorson, Christian L., Young, Philip J.

“…The Ewing Sarcoma (EWS) protein is a ubiquitously expressed RNA processing factor that localises predominantly to the nucleus. However, the mechanism through…”
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Population screening for spinal muscular atrophy: A mixed methods study of the views of affected families by Boardman, Felicity K., Young, Philip J., Griffiths, Frances E.

“…Autosomal recessive conditions are a significant health burden with few treatments. Population carrier screening has been suggested as a means to tackle them…”
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Identification of a self-association domain in the Ewing's sarcoma protein: a novel function for arginine-glycine-glycine rich motifs? by Shaw, Debra J, Morse, Robert, Todd, Adrian G, Eggleton, Paul, Lorson, Christian L, Young, Philip J

“…The Ewing's sarcoma (EWS) protein is a ubiquitously expressed RNA chaperone. The EWS protein localizes predominantly to the nucleus. Previous reports have…”
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Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy by Wishart, Thomas M, Mutsaers, Chantal A, Riessland, Markus, Reimer, Michell M, Hunter, Gillian, Hannam, Marie L, Eaton, Samantha L, Fuller, Heidi R, Roche, Sarah L, Somers, Eilidh, Morse, Robert, Young, Philip J, Lamont, Douglas J, Hammerschmidt, Matthias, Joshi, Anagha, Hohenstein, Peter, Morris, Glenn E, Parson, Simon H, Skehel, Paul A, Becker, Thomas, Robinson, Iain M, Becker, Catherina G, Wirth, Brunhilde, Gillingwater, Thomas H

“…The autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA) results from low levels of survival motor neuron (SMN) protein; however, it is…”
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Newborn screening for haemophilia: The views of families and adults living with haemophilia in the UK by Boardman, Felicity K., Hale, Rachel, Young, Philip J.

“…Introduction As genomic sequencing become more efficient and cost‐effective, the number of conditions identified through newborn screening globally is set to…”
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The role of experiential knowledge within attitudes towards genetic carrier screening: A comparison of people with and without experience of spinal muscular atrophy by Boardman, Felicity K., Young, Philip J., Warren, Oliver, Griffiths, Frances E.

“…Purpose Autosomal recessive conditions, while individually rare, are a significant health burden with limited treatment options. Population carrier screening…”
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Newborn screening for spinal muscular atrophy: The views of affected families and adults by Boardman, Felicity K., Young, Philip J., Griffiths, Frances E.

“…Spinal muscular atrophy (SMA) is one of the leading genetic causes of infant death worldwide. However, due to a lack of treatments, SMA has historically fallen…”
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Impairment Experiences, Identity and Attitudes Towards Genetic Screening: the Views of People with Spinal Muscular Atrophy by Boardman, Felicity K., Young, Philip J., Griffiths, Frances E.

“…Developments in genetics are rapidly changing the capacity and scope of screening practices. However, people with genetic conditions have been…”
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Femtosecond Study of Dimolybdenum Paddlewheel Compounds with Amide/Thioamide Ligands: Symmetry, Electronic Structure, and Charge Distribution in the 1MLCT S1 State by Jiang, Changcheng, Young, Philip J., Brown-Xu, Samantha, Gallucci, Judith C., Chisholm, Malcolm H.

“…Four photophysically interesting dimolybdenum paddlewheel compounds are synthesized and characterized: I and II contain amide ligand…”
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Preventing lives affected by hemophilia: A mixed methods study of the views of adults with hemophilia and their families toward genetic screening by Boardman, Felicity K., Hale, Rachel, Gohel, Raksha, Young, Philip J.

“…Background Genomic sequencing technologies have made the possibility of population screening for whole panels of genetic disorders more feasible than ever…”
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Minute Virus of Mice NS1 Interacts with the SMN Protein, and They Colocalize in Novel Nuclear Bodies Induced by Parvovirus Infection by Young, Philip J, Jensen, Klaus T, Burger, Lisa R, Pintel, David J, Lorson, Christian L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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