Search Results - "Young, Pampee P"

Young apheresis platelet donors show significant and sustained growth over the last decade in the US, 2010–2019: A favorable sign of the resiliency of the platelet supply by Lasky, Baia, Singh, Umesh, Young, Pampee P.

“…Background Platelet demand continues to rise and US hospitals frequently face shortages. The peak median age of apheresis platelet donors (APD) is believed to…”
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Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing by Saraswati, Sarika, Marrow, Stephanie M. W., Watch, Lester A., Young, Pampee P.

“…Fibrosis accompanying wound healing can drive the failure of many different organs. Activated fibroblasts are the principal determinants of post-injury…”
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Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling by Saraswati, Sarika, Alfaro, Maria P, Thorne, Curtis A, Atkinson, James, Lee, Ethan, Young, Pampee P

“…Wnt signaling plays an important role in developmental and stem cell biology. To test the hypothesis that temporary inhibition of Wnt signaling will enhance…”
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COVID‐19 convalescent plasma donors: Unique motivations in unique times? by Crowder, Lauren A., Steele, Whitney R., Goodhue, Erin, Lasky, Baia, Young, Pampee P.

“…Background Early in the SARS‐CoV‐2 pandemic, many blood collection organizations (BCOs) were asked to collect and distribute COVID‐19 convalescent plasma (CCP)…”
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Cell-based therapies for cardiac disease: a cellular therapist's perspective by Young, Pampee P., Schäfer, Richard

“…Cell‐based therapy is an exciting, promising, and a developing new treatment for cardiac diseases. Stem cell–based therapies have the potential to…”
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sFRP2 Suppression of Bone Morphogenic Protein (BMP) and Wnt Signaling Mediates Mesenchymal Stem Cell (MSC) Self-renewal Promoting Engraftment and Myocardial Repair by Alfaro, Maria P., Vincent, Alicia, Saraswati, Sarika, Thorne, Curtis A., Hong, Charles C., Lee, Ethan, Young, Pampee P.

“…Transplantation of mesenchymal stem cells (MSCs) is a promising therapy for ischemic injury; however, inadequate survival of implanted cells in host tissue is…”
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The Wnt Modulator sFRP2 Enhances Mesenchymal Stem Cell Engraftment, Granulation Tissue Formation and Myocardial Repair by Alfaro, Maria P., Pagni, Matthew, Vincent, Alicia, Atkinson, James, Hill, Michael F., Cates, Justin, Davidson, Jeffrey M., Rottman, Jeffrey, Lee, Ethan, Young, Pampee P.

“…Cell-based therapies, using multipotent mesenchymal stem cells (MSCs) for organ regeneration, are being pursued for cardiac disease, orthopedic injuries and…”
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A physiological role for connective tissue growth factor in early wound healing by Alfaro, Maria P, Deskins, Desirae L, Wallus, Meredith, DasGupta, Jayasri, Davidson, Jeffrey M, Nanney, Lillian B, A Guney, Michelle, Gannon, Maureen, Young, Pampee P

“…Mesenchymal stem cells (MSCs) that overexpress secreted frizzled-related protein 2 (sFRP2) exhibit an enhanced reparative phenotype. The secretomes of…”
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Brown Recluse spider bite mediated hemolysis: clinical features, a possible role for complement inhibitor therapy, and reduced RBC surface glycophorin A as a potential biomarker of venom exposure by Gehrie, Eric A, Nian, Hui, Young, Pampee P

“…The venom of Loxosceles reclusa (Brown Recluse spider) can cause a severe, life-threatening hemolysis in humans for which no therapy is currently available in…”
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Wnt/β‐catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration by Bastakoty, Dikshya, Young, Pampee P.

“…ABSTRACT The Wnt/β‐catenin pathway is an evolutionarily conserved set of signals with critical roles in embryonic and neonatal development across species. In…”
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Loss of SPRR3 in ApoE-/- mice leads to atheroma vulnerability through Akt dependent and independent effects in VSMCs by Lietman, Caressa D, Segedy, Amanda K, Li, Bin, Fazio, Sergio, Atkinson, James B, Linton, MacRae F, Young, Pampee P

“…Vascular smooth muscle cells (VSMCs) represent important modulators of plaque stability in advanced lesions. We previously reported that loss of small…”
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Redefining Blood Donation—Path to Inclusivity and Safety by Young, Pampee P., Saa, Paula

“…This Viewpoint reviews the vicissitudes of establishing fair and equitable blood donation policies based on research and improved serological testing and…”
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Human Mesenchymal Stromal Cells: Identifying Assays to Predict Potency for Therapeutic Selection by Deskins, Desirae L., Bastakoty, Dikshya, Saraswati, Sarika, Shinar, Andrew, Holt, Ginger E., Young, Pampee P.

“…The goal of this study was to identify feasible and reproducible in vitro assays to predict mesenchymal stromal cell (MSC) potency. MSC lines were generated…”
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Lessons from genetically altered mesenchymal stem cells (MSCs): candidates for improved MSC-directed myocardial repair by Alfaro, Maria P, Young, Pampee P

“…The regenerative and reparative potential of mesenchymal stem cells (MSCs) make them attractive candidates for numerous cell-directed therapies. The variant…”
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Conservation of Rh negative Low Titer O Whole Blood (LTOWB) and the need for a national conversation to define its use in trauma transfusion protocols by Troughton, Marla, Young, Pampee P.

“…Low‐titer group O whole blood (LTOWB) use is growing steadily in the United States. Although the percentage of O negative LTOWB use by Red Cross hospitals has…”
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Reducing intraoperative red blood cell unit wastage in a large academic medical center by Whitney, Gina M., Woods, Marcella C., France, Daniel J., Austin, Thomas M., Deegan, Robert J., Paroskie, Allison, Booth, Garrett S., Young, Pampee P., Dmochowski, Roger R., Sandberg, Warren S., Pilla, Michael A.

“…BACKGROUND The wastage of red blood cell (RBC) units within the operative setting results in significant direct costs to health care organizations. Previous…”
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Pyrvinium, a potent small molecule Wnt inhibitor, increases engraftment and inhibits lineage commitment of mesenchymal stem cells (MSCs) by Saraswati, Sarika, Deskins, Desirae L., Holt, Ginger E., Young, Pampee P.

“…We and others have found that Wnt signaling inhibition is important in mesenchymal stem cell (MSC) self‐renewal. Pyrvinium was identified as a potent Wnt…”
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Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products by Oakley, Fredrick D., Woods, Marcella, Arnold, Shanna, Young, Pampee P.

“…Background The majority of reports on transfusion reactions address adult patients. Less is known about the types, incidence, and other clinical details of…”
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Rural hospitals and access to platelets for treating active bleeding: Is the heartland bleeding? by Young, Pampee P., Ehrhart, Jan, Mair, David

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The operational and financial impact of adding anaerobic screening of platelets by Rios, Jorge, Webb, Jonathan, Dy, Beth, Young, Pampee P.

“…Background and Objectives We evaluated the operational and safety impact of implementing anaerobic culture screening of apheresis and pooled platelets at the…”
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