Search Results - "Young, Neil T"

Novel mRNA-specific effects of ribosome drop-off on translation rate and polysome profile by Bonnin, Pierre, Kern, Norbert, Young, Neil T, Stansfield, Ian, Romano, M Carmen

“…The well established phenomenon of ribosome drop-off plays crucial roles in translational accuracy and nutrient starvation responses during protein…”
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Genomic Programming of Human Neonatal Dendritic Cells in Congenital Systemic and In Vitro Cytomegalovirus Infection Reveal Plastic and Robust Immune Pathway Biology Responses by Dantoft, Widad, Martínez-Vicente, Pablo, Jafali, James, Pérez-Martínez, Lara, Martin, Kim, Kotzamanis, Konstantinos, Craigon, Marie, Auer, Manfred, Young, Neil T, Walsh, Paul, Marchant, Arnaud, Angulo, Ana, Forster, Thorsten, Ghazal, Peter

“…Neonates and especially premature infants are highly susceptible to infection but still can have a remarkable resilience that is poorly understood. The view…”
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HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C by Braud, Veronique M, Allan, David S. J, O'Callaghan, Christopher A, Söderström, Kalle, D'Andrea, Annalisa, Ogg, Graham S, Lazetic, Sasha, Young, Neil T, Bell, John I, Phillips, Joseph H, Lanier, Lewis L, McMichael, Andrew J

“…The protein HLA-E is a non-classical major histocompatibility complex (MHC) molecule of limited sequence variability. Its expression on the cell surface is…”
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Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G by Eagle, Robert A, Flack, Gillian, Warford, Anthony, Martínez-Borra, Jesús, Jafferji, Insiya, Traherne, James A, Ohashi, Maki, Boyle, Louise H, Barrow, Alexander D, Caillat-Zucman, Sophie, Young, Neil T, Trowsdale, John

“…The activating immunoreceptor NKG2D is expressed on Natural Killer (NK) cells and subsets of T cells. NKG2D contributes to anti-tumour and anti-viral immune…”
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Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes by Jones, Des C, Roghanian, Ali, Brown, Damien P, Chang, Chiwen, Allen, Rachel L, Trowsdale, John, Young, Neil T

“…Leucocyte Ig-like receptors (LILR) are a family of innate immune receptors expressed on myeloid and lymphoid cells that influence adaptive immune responses. We…”
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Leukocyte Ig‐Like receptor B1 restrains dendritic cell function through increased expression of the NF‐κB regulator ABIN1/TNIP1 by Khanolkar, Rahul C., Kalogeropoulos, Michail, Lawrie, Alistair, Roghanian, Ali, Vickers, Mark A., Young, Neil T.

“…Increased ABIN1/TNIP1 expression in monocyte derived DCs, mediated by LILRB1 ligation, stalls their maturation and stimulatory capacity. Inhibitory receptors…”
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Comparison of Chimpanzee and Human Leukocyte Ig-Like Receptor Genes Reveals Framework and Rapidly Evolving Genes by Canavez, Flavio, Young, Neil T, Guethlein, Lisbeth A, Rajalingam, Raja, Khakoo, Salim I, Shum, Benny P, Parham, Peter

“…The leukocyte receptor complex (LRC) on human chromosome 19 contains related Ig superfamily killer cell Ig-like receptor (KIR) and leukocyte Ig-like receptor…”
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The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells by Young, Neil T., Waller, Edward C.P., Patel, Rashmi, Roghanian, Ali, Austyn, Jonathan M., Trowsdale, John

“…Dendritic cells (DCs) link innate and adaptive immunity, initiating and regulating effector cell responses. They ubiquitously express members of the LILR (ILT,…”
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Two Human ULBP/RAET1 Molecules with Transmembrane Regions Are Ligands for NKG2D by Bacon, Louise, Eagle, Robert A, Meyer, Martina, Easom, Nicholas, Young, Neil T, Trowsdale, John

“…We characterized two novel members of the RAET1/ULBP gene cluster, RAET1E and RAET1G. The encoded proteins were similar to the ULBP in their class I-like…”
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Nature of allelic sequence polymorphism at the KIR3DL3 locus by Jones, Des C., Hiby, Susan E., Moffett, Ashley, Trowsdale, John, Young, Neil T.

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Does memory improve with age? CD85j (ILT-2 LIR-1) expression on CD8 T cells correlates with 'memory inflation' in human cytomegalovirus infection by Northfield, John, Lucas, Michaela, Jones, Helena, Young, Neil T, Klenerman, Paul

“…CMV‐specific memory CD8+ T cells accumulate over time to reach high frequencies amongst peripheral blood lymphocytes – a phenomenon termed ‘memory inflation’…”
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Differential Expression of Leukocyte Receptor Complex-Encoded Ig-Like Receptors Correlates with the Transition from Effector to Memory CTL by Young, Neil T, Uhrberg, Markus, Phillips, Joseph H, Lanier, Lewis L, Parham, Peter

“…The human leukocyte receptor complex (LRC) on chromosome 19q13.4 encodes Ig superfamily receptors expressed on hemopoietic cells. Killer Ig-like receptors…”
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Frequency and Phenotype of Circulating Vα24/Vβ11 Double-Positive Natural Killer T Cells during Hepatitis C Virus Infection by Lucas, Michaela, Gadola, Stephan, Meier, Ute, Young, Neil T., Harcourt, Gillian, Karadimitris, Anastasios, Coumi, Nikki, Brown, Dave, Dusheiko, Geoff, Cerundolo, Vincenzo, Klenerman, Paul

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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KIR expression shapes cytotoxic repertoires: a developmental program of survival by Young, Neil T, Uhrberg, Markus

“…We hypothesize a sequential program of expression of the leukocyte-receptor complex (LRC) in CD8 + T cells, associated with cellular activation and the…”
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Filament-associated TSGA10 protein is expressed in professional antigen presenting cells and interacts with vimentin by Roghanian, Ali, Jones, Des C., Pattisapu, Jogi V., Wolfe, Jonathan, Young, Neil T., Behnam, Babak

“…Testis-specific gene antigen 10 (TSGA10) encodes an 82-kDa protein expressed during development, and in testis and brain tissues. We report its expression in…”
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Immunobiology of natural killer lymphocytes in transplantation by Young, Neil T

“…Natural killer (NK) lymphocytes are powerful effector cells of the peripheral immune system. NK cell functions are controlled by the expression of a variety of…”
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KIR2DL5, a Novel Killer-Cell Receptor with a D0-D2 Configuration of Ig-Like Domains by Vilches, Carlos, Rajalingam, Raja, Uhrberg, Markus, Gardiner, Clair M, Young, Neil T, Parham, Peter

“…Four novel killer-cell Ig-like receptor (KIR) genes were discovered by analysis of genomic DNA from a human donor. One gene, KIR2DL5, is expressed by…”
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Nature of allelic sequence polymorphism at the KIR3DL3 locus by Jones, Des C, Hiby, Susan E, Moffett, Ashley, Trowsdale, John, Young, Neil T

“…KIR3DL3 is a framework gene of the Leukocyte Receptor Complex, present in all individuals and haplotypes analysed to date. We describe 17 novel KIR3DL3…”
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Correction: Cellular Expression, Trafficking, and Function of Two Isoforms of Human ULBP5/RAET1G by Eagle, Robert A., Flack, Gillian, Warford, Anthony, Martínez-Borra, Jesús, Jafferji, Insiya, Traherne, James A., Ohashi, Maki, Boyle, Louise H., Barrow, Alexander D., Caillat-Zucman, Sophie, Young, Neil T., Trowsdale, John

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Permissible and immunogenic HLA-A mismatches: cytotoxic T-cell precursor frequencies reflect graft survival data by Roelen, Dave L, Stobbe, Inge, Young, Neil T, van Bree, Simone P.M.J, Doxiadis, Ilias I.N, Oudshoorn, M, Morris, Peter J, Wood, Kathryn J, Claas, Frans H.J

“…Analysis of the in vivo immunogenicity of single HLA mismatches, in the context of a patient’s own human leukocyte antigen (HLA) phenotype, has been used to…”
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