Search Results - "Young, Michael W"

Molecular mechanisms and physiological importance of circadian rhythms by Patke, Alina, Young, Michael W., Axelrod, Sofia

“…To accommodate daily recurring environmental changes, animals show cyclic variations in behaviour and physiology, which include prominent behavioural states…”
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insomniac and Cullin-3 Regulate Sleep and Wakefulness in Drosophila by Stavropoulos, Nicholas, Young, Michael W.

“…In a forward genetic screen in Drosophila, we have isolated insomniac, a mutant that severely reduces the duration and consolidation of sleep…”
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Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior by Top, Deniz, Young, Michael W

“…Specialized groups of neurons in the brain are key mediators of circadian rhythms, receiving daily environmental cues and communicating those signals to other…”
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Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder by Patke, Alina, Murphy, Patricia J., Onat, Onur Emre, Krieger, Ana C., Özçelik, Tayfun, Campbell, Scott S., Young, Michael W.

“…Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes ∼24 hr rhythms in many behavioral and physiological processes…”
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Interactive Features of Proteins Composing Eukaryotic Circadian Clocks by Crane, Brian R, Young, Michael W

“…Research into the molecular mechanisms of eukaryotic circadian clocks has proceeded at an electrifying pace. In this review, we discuss advances in our…”
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Chronic social isolation signals starvation and reduces sleep in Drosophila by Li, Wanhe, Wang, Zikun, Syed, Sheyum, Lyu, Cheng, Lincoln, Samantha, O’Neil, Jenna, Nguyen, Andrew D., Feng, Irena, Young, Michael W.

“…Social isolation and loneliness have potent effects on public health 1 – 4 . Research in social psychology suggests that compromised sleep quality is a key…”
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Temperature compensation and temperature sensation in the circadian clock by Kidd, Philip B., Young, Michael W., Siggia, Eric D.

“…All known circadian clocks have an endogenous period that is remarkably insensitive to temperature, a property known as temperature compensation, while at the…”
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Control of Sleep by Cyclin A and Its Regulator by Rogulja, Dragana, Young, Michael W.

“…How and why the brain reversibly switches from a waking to a sleep state remain among the most intriguing questions in biology. We show that cyclin A (CycA)…”
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Interplay of circadian clocks and metabolic rhythms by Wijnen, Herman, Young, Michael W

“…This review examines the connections between circadian and metabolic rhythms. Examples from a wide variety of well-studied organisms are used to illustrate…”
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Chronic sleep loss disrupts rhythmic gene expression in Drosophila by Wang, Zikun, Lincoln, Samantha, Nguyen, Andrew D, Li, Wanhe, Young, Michael W

“…Genome-wide profiling of rhythmic gene expression has offered new avenues for studying the contribution of circadian clock to diverse biological processes…”
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Flavin reduction activates Drosophila cryptochrome by Vaidya, Anand T., Top, Deniz, Manahan, Craig C., Tokuda, Joshua M., Zhang, Sheng, Pollack, Lois, Young, Michael W., Crane, Brian R.

“…Entrainment of circadian rhythms in higher organisms relies on light-sensing proteins that communicate to cellular oscillators composed of delayed…”
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Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus by Jang, A Reum, Moravcevic, Katarina, Saez, Lino, Young, Michael W, Sehgal, Amita

“…Regulated nuclear entry of clock proteins is a conserved feature of eukaryotic circadian clocks and serves to separate the phase of mRNA activation from mRNA…”
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Changes in active site histidine hydrogen bonding trigger cryptochrome activation by Ganguly, Abir, Manahan, Craig C., Top, Deniz, Yee, Estella F., Lin, Changfan, Young, Michael W., Thiel, Walter, Crane, Brian R.

“…Cryptochrome (CRY) is the principal light sensor of the insect circadian clock. Photoreduction of the Drosophila CRY (dCRY) flavin cofactor to the anionic…”
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Studying circadian rhythm and sleep using genetic screens in Drosophila by Axelrod, Sofia, Saez, Lino, Young, Michael W

“…The power of Drosophila melanogaster as a model organism lies in its ability to be used for large-scale genetic screens with the capacity to uncover the…”
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Updated structure of Drosophila cryptochrome by Levy, Colin, Zoltowski, Brian D., Jones, Alex R., Vaidya, Anand T., Top, Deniz, Widom, Joanne, Young, Michael W., Scrutton, Nigel S., Crane, Brian R., Leys, David

“…Arising from B. D. Zoltowski et al. Nature480, 396–399 (2011)10.1038/nature10618 Recently, we determined the X-ray crystal structure of full-length…”
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Integration of light and temperature in the regulation of circadian gene expression in Drosophila by Boothroyd, Catharine E, Wijnen, Herman, Naef, Felix, Saez, Lino, Young, Michael W

“…Circadian clocks are aligned to the environment via synchronizing signals, or Zeitgebers, such as daily light and temperature cycles, food availability, and…”
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Activating PER repressor through a DBT-directed phosphorylation switch by Kivimäe, Saul, Saez, Lino, Young, Michael W

“…Protein phosphorylation plays an essential role in the generation of circadian rhythms, regulating the stability, activity, and subcellular localization of…”
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CK1/Doubletime activity delays transcription activation in the circadian clock by Top, Deniz, O'Neil, Jenna L, Merz, Gregory E, Dusad, Kritika, Crane, Brian R, Young, Michael W

“…In the circadian clock, Period (PER) and Timeless (TIM) proteins inhibit Clock-mediated transcription of and genes until PER is degraded by Doubletime/CK1…”
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Time Travels: A 40‐Year Journey from Drosophila's Clock Mutants to Human Circadian Disorders (Nobel Lecture) by Young, Michael W.

“…Living organisms have a biological clock that helps to prepare our physiology for the fluctuations of the day. Key research to elucidate the biological…”
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kuzbanian-mediated cleavage of Drosophila Notch by Lieber, Toby, Kidd, Simon, Young, Michael W

“…Loss of Kuzbanian, a member of the ADAM family of metalloproteases, produces neurogenic phenotypes in Drosophila. It has been suggested that this results from…”
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