Search Results - "Young, M. Rita"

Redirecting the focus of cancer immunotherapy to premalignant conditions by Young, M. Rita I

“…Abstract Much progress has been made in introducing immunological treatment approaches for cancer, with lessons learned from both the successes and failures of…”
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PTSD, a Disorder with an Immunological Component by Wang, Zhewu, Young, M Rita I

“…Post-traumatic stress disorder (PTSD) has been associated with an inflammatory state. However, few studies have addressed the mechanisms underlying this immune…”
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Immunological effects of nivolumab immunotherapy in patients with oral cavity squamous cell carcinoma by Xiong, Ying, Neskey, David M, Horton, Joshua D, Paulos, Chrystal M, Knochelmann, Hannah M, Armeson, Kent E, Young, M Rita I

“…Although checkpoint blockades have become widely used, the immunological impact in cancer patients, especially those with oral cavity squamous cell carcinoma…”
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Posttraumatic Stress Disorder: An Immunological Disorder? by Wang, Zhewu, Caughron, Blaine, Young, M Rita I

“…Patients with posttraumatic stress disorder (PTSD) exhibit an increased state of inflammation. Various animal models for PTSD have shown some of the same…”
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NK-Dependent Increases in CCL22 Secretion Selectively Recruits Regulatory T Cells to the Tumor Microenvironment by Mailloux, Adam W, Young, M. Rita I

“…Tumor-induced immune suppression involves the accumulation of immune-suppressive infiltrates in the microenvironment. This study demonstrates increased numbers…”
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Endothelial cells in the eyes of an immunologist by Young, M. Rita

“…Endothelial cell activation in the process of tumor angiogenesis and in various aspects of vascular biology has been extensively studied. However, endothelial…”
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Role of IL-23 signaling in the progression of premalignant oral lesions to cancer by Caughron, Blaine, Yang, Yi, Young, M Rita I

“…Mice bearing carcinogen-induced premalignant oral lesions were previously shown to have a pro-inflammatory phenotype, which is replaced with an immune…”
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Characterization of the evolution of immune phenotype during the development and progression of squamous cell carcinoma of the head and neck by De Costa, Anna-Maria A., Schuyler, Corinne A., Walker, David D., Young, M. Rita I.

“…While studies have indicated that squamous cell carcinoma of the head and neck (HNSCC) is associated with immune suppression, these studies did not analyze the…”
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Tumors induce the formation of suppressor endothelial cells in vivo by Mulligan, Jennifer Konopa, Young, M. Rita I

“…Patients with solid tumors have defects in immune effector cells, which have been associated with a poorer prognosis. Previous studies by our laboratory have…”
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Neoadjuvant presurgical PD-1 inhibition in oral cavity squamous cell carcinoma by Knochelmann, Hannah M., Horton, Joshua D., Liu, Sixue, Armeson, Kent, Kaczmar, John M., Wyatt, Megan M., Richardson, Mary S., Lomeli, Shirley H., Xiong, Ying, Graboyes, Evan M., Lentsch, Eric J., Hornig, Joshua D., Skoner, Judith, Stalcup, Seth, Spampinato, Maria V., Garrett-Mayer, Elizabeth, O’Quinn, Elizabeth C., Timmers, Cynthia D., Romeo, Martin J., Wrangle, John M., Young, M. Rita I., Rubinstein, Mark P., Day, Terry A., Lo, Roger S., Paulos, Chrystal M., Neskey, David M.

“…Oral cavity squamous cell carcinoma (OCSCC) is a prevalent surgically treated subset of head and neck cancer with frequent recurrence and poor survival…”
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Use of α,25-Dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma by Walsh, Jarrett E, Clark, Anna-Maria, Day, Terry A, Gillespie, M. Boyd, Young, M. Rita I

“…Abstract Prior studies have shown that treatment of head and neck squamous cell carcinoma (HNSCC) patients with 1α,25-dihydroxyvitamin D3 [1,25(OH)2 D3 ]…”
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Cancer Immunology with a Focus on Understudied Cancers as Targets for Immunotherapy by Young, M Rita I

“…n/a…”
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Reduced Expression of Immune Mediators by T-Cell Subpopulations of Combat-Exposed Veterans With Post-Traumatic Stress Disorder by Xiong, Ying, Wang, Zhewu, Young, M Rita I

“…Post-traumatic stress disorder (PTSD) has been suggested to be associated with an inflammatory immune state, although few studies have examined peripheral…”
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Restoration of Immune Responsiveness to Glioma by Vaccination of Mice with Established Brain Gliomas with a Semi-Allogeneic Vaccine by Gattoni-Celli, Sebastiano, Young, M Rita I

“…Prior studies had shown the clinical efficacy of a semi-allogeneic glioma vaccine in mice with lethal GL261 gliomas. This was confirmed in the present study…”
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Role of a novel immune modulating DDR2-expressing population in silica-induced pulmonary fibrosis by McDonald, Lindsay T, Johnson, Sara D, Russell, Dayvia L, Young, M Rita I, LaRue, Amanda C

“…Micro-injuries associated with chronic inhaled particle exposures are linked with activation of the immune response and are thought to contribute to…”
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Protective mechanisms of head and neck squamous cell carcinomas from immune assault by Young, M. Rita I.

“…Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy that is the sixth most common neoplasm in the world. Despite advances in treatments…”
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High-Fat Diet Alters Immunogenic Properties of Circulating and Adipose Tissue-Associated Myeloid-Derived CD45+DDR2+ Cells by LaRue, Amanda C., Young, M. Rita I., Xiong, Ying, Sidles, Sara J.

“…Chronic inflammation is evident in the adipose tissue and periphery of patients with obesity, as well as mouse models of obesity. T cell subsets in obese…”
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Tumor Secretion of VEGF Induces Endothelial Cells to Suppress T cell Functions Through the Production of PGE2 by MULLIGAN, Jennifer K, ROSENZWEIG, Steven A, YOUNG, M. Rita I

“…Endothelial cells are potent regulators of immune cell functions and have therefore been examined to determine their role in tumor-induced immune suppression…”
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Use of Carcinogen-induced Premalignant Oral Lesions in a Dendritic Cell-based Vaccine to Stimulate Immune Reactivity Against Both Premalignant Oral Lesions and Oral Cancer by YOUNG, M. Rita I

“…Select groups of premalignant oral lesions carry a high risk of development of secondary premalignant lesions and oral squamous cell carcinoma (OSCC). The goal…”
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TGF-β Regulation of Focal Adhesion Proteins and Motility of Premalignant Oral Lesions via Protein Phosphatase 1 by WALSH, Jarrett E, YOUNG, M. Rita I

“…Premalignant oral lesions have a high incidence of recurrence and progression to malignant disease and, although studies have shown the contribution of…”
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