Search Results - "Young, Lawrence S."

Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection by Palser, Anne L, Grayson, Nicholas E, White, Robert E, Corton, Craig, Correia, Samantha, Ba Abdullah, Mohammed M, Watson, Simon J, Cotten, Matthew, Arrand, John R, Murray, Paul G, Allday, Martin J, Rickinson, Alan B, Young, Lawrence S, Farrell, Paul J, Kellam, Paul

“…Epstein-Barr virus (EBV) infects most of the world's population and is causally associated with several human cancers, but little is known about how EBV…”
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The natural history of cervical HPV infection: unresolved issues by Woodman, Ciaran B. J, Collins, Stuart I, Young, Lawrence S

“…The identification of high-risk human papillomavirus (HPV) types as a necessary cause of cervical cancer offers the prospect of effective primary prevention…”
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The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy by Lo, Angela Kwok-Fung, Dawson, Christopher W, Lung, Hong Lok, Wong, Ka-Leung, Young, Lawrence S

“…Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) infection. It is also characterized by heavy infiltration with non-malignant…”
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Activation of sterol regulatory element‐binding protein 1 (SREBP1)‐mediated lipogenesis by the Epstein–Barr virus‐encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma by Lo, Angela Kwok‐Fung, Lung, Raymond Wai‐Ming, Dawson, Christopher W, Young, Lawrence S, Ko, Chuen‐Wai, Yeung, Walter Wai, Kang, Wei, To, Ka‐Fai, Lo, Kwok‐Wai

“…Nasopharyngeal carcinoma (NPC) is closely associated with Epstein–Barr virus (EBV) infection. The EBV‐encoded latent membrane protein 1 (LMP1), which is…”
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Contributions of the Epstein-Barr Virus EBNA1 Protein to Gastric Carcinoma by SIVACHANDRAN, Nirojini, DAWSON, Christopher W, YOUNG, Lawrence S, LIU, Fei-Fei, MIDDELDORP, Jaap, FRAPPIER, Lori

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Pathogens : Journal Section Readjustment by Young, Lawrence S

“…The impact of infectious diseases on human life is incalculable [...]…”
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Viral gene therapy strategies: from basic science to clinical application by Young, Lawrence S, Searle, Peter F, Onion, David, Mautner, Vivien

“…A major impediment to the successful application of gene therapy for the treatment of a range of diseases is not a paucity of therapeutic genes, but the lack…”
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Epstein–Barr virus: more than 50 years old and still providing surprises by Young, Lawrence S., Yap, Lee Fah, Murray, Paul G.

“…This Timeline article describes the discovery of the Epstein–Barr virus and summarizes the key advances in the field that have led to our current understanding…”
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Epstein–Barr virus at 60 by Young, Lawrence S.

“…The 1964 discovery of Epstein–Barr virus shed light on factors that contribute to human cancer. Subsequent studies set the stage for finding ways to diagnose…”
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Cancer drug sensitivity prediction from routine histology images by Dawood, Muhammad, Vu, Quoc Dang, Young, Lawrence S., Branson, Kim, Jones, Louise, Rajpoot, Nasir, Minhas, Fayyaz ul Amir Afsar

“…Drug sensitivity prediction models can aid in personalising cancer therapy, biomarker discovery, and drug design. Such models require survival data from…”
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Epstein-Barr Virus-Encoded LMP1 Regulates Epithelial Cell Motility and Invasion via the ERK-MAPK Pathway by DAWSON, Christopher W, LAVERICK, Louise, MORRIS, Mhairi A, TRAMOUTANIS, Giorgos, YOUNG, Lawrence S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Therapeutic Potential of Targeting BARF1 in EBV-Associated Malignancies by Lo, Angela Kwok-Fung, Dawson, Christopher W., Lung, Hong Lok, Wong, Ka-Leung, Young, Lawrence S.

“…Epstein-Barr virus (EBV) is closely linked to the development of a number of human cancers. EBV-associated malignancies are characterized by a restricted…”
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Advances in pathogenesis and precision medicine for nasopharyngeal carcinoma by Zhu, Qian‐Ying, Zhao, Ge‐Xin, Li, Yan, Talakatta, Girish, Mai, Hai‐Qiang, Le, Quynh‐Thu, Young, Lawrence S., Zeng, Mu‐Sheng

“…Nasopharyngeal carcinoma (NPC) is a squamous carcinoma with apparent geographical and racial distribution, mostly prevalent in East and Southeast Asia,…”
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Epstein-Barr virus and nasopharyngeal carcinoma by Young, Lawrence S, Dawson, Christopher W

“…Since its discovery 50 years ago, Epstein-Barr virus （EBV） has been linked to the development of cancers originating from both lymphoid and epithelial cells…”
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Role of the Epstein-Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma by Morris, Mhairi A, Dawson, Christopher W, Young, Lawrence S

“…Although frequently expressed in Epstein-Barr virus (EBV)-positive malignancies, the contribution of the oncogenic latent membrane protein-1 (LMP1) to the…”
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The EBV-Encoded Oncoprotein, LMP1, Recruits and Transforms Fibroblasts via an ERK-MAPK-Dependent Mechanism by Davis, Alexandra M, Rapley, Abigail, Dawson, Christopher W, Young, Lawrence S, Morris, Mhairi A

“…Latent membrane protein 1 (LMP1), the major oncoprotein encoded by Epstein–Barr virus (EBV), is expressed at widely variable levels in undifferentiated…”
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Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study by Woodman, Ciaran BJ, Collins, Stuart, Winter, Heather, Bailey, Andrew, Ellis, John, Prior, Pat, Yates, Marie, Rollason, Terry P, Young, Lawrence S

“…Laboratory and epidemiological research suggests an association between human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN). We studied the…”
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Disruption of the E2 Gene Is a Common and Early Event in the Natural History of Cervical Human Papillomavirus Infection: A Longitudinal Cohort Study by COLLINS, Stuart I, CONSTANDINOU-WILLIAMS, Christothea, KAISHENG WEN, YOUNG, Lawrence S, ROBERTS, Sally, MURRAY, Paul G, WOODMAN, Ciaran B. J

“…Integration of high-risk human papillomavirus (HPV) types into the host-cell genome disrupts the HPV regulatory E2 protein, resulting in a loss of negative…”
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An etiological role for the Epstein-Barr virus in the pathogenesis of classical Hodgkin lymphoma by Murray, Paul G., Young, Lawrence S.

“…Although a pathogenic role for the Epstein-Barr virus (EBV) is largely undisputed for tumors that are consistently EBV genome positive (eg, nasopharyngeal…”
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A global view of the oncogenic landscape in nasopharyngeal carcinoma: an integrated analysis at the genetic and expression levels by Hu, Chunfang, Wei, Wenbin, Chen, Xiaoyi, Woodman, Ciaran B, Yao, Yunhong, Nicholls, John M, Joab, Irène, Sihota, Sim K, Shao, Jian-Yong, Derkaoui, K Dalia, Amari, Aicha, Maloney, Stephanie L, Bell, Andrew I, Murray, Paul G, Dawson, Christopher W, Young, Lawrence S, Arrand, John R

“…Previous studies have reported that the tumour cells of nasopharyngeal carcinoma (NPC) exhibit recurrent chromosome abnormalities. These genetic changes are…”
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