Search Results - "Young, Kira A."

Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis by SanMiguel, Jennifer M, Eudy, Elizabeth, Loberg, Matthew A, Young, Kira A, Mistry, Jayna J, Mujica, Kristina D, Schwartz, Logan S, Stearns, Timothy M, Challen, Grant A, Trowbridge, Jennifer J

“…Clonal hematopoiesis resulting from the enhanced fitness of mutant hematopoietic stem cells (HSC) associates with both favorable and unfavorable health…”
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Variation in mesenchymal KITL/SCF and IGF1 expression in middle age underlies steady-state hematopoietic stem cell aging by Young, Kira A., Telpoukhovskaia, Maria A., Hofmann, Johanna, Mistry, Jayna J., Kokkaliaris, Konstantinos D., Trowbridge, Jennifer J.

“…•Kitl and Igf1 in MSCs at middle age correlates with aging-associated molecular programs in HSCs in individual mice.•Elevation of proinflammatory cytokines is…”
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Transcriptional and functional consequences of Oncostatin M signaling on young Dnmt3a-mutant hematopoietic stem cells by Schwartz, Logan S., Young, Kira A., Stearns, Timothy M., Boyer, Nathan, Mujica, Kristina D., Trowbridge, Jennifer J.

“…•Oncostatin M (OSM) signaling is elevated in Dnmt3a-mutant hematopoietic stem cells (HSCs) with aging.•OSM does not functionally impact young Dnmt3a-mutant…”
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Elevated Functional Hematopoietic Stem and Progenitor Cells in the Peripheral Blood of G-CSF-Mobilized Dnmt3a-Mutant Mice by Young, Kira A., Nye, Griffin J., Trowbridge, Jennifer J.

“…Clonal hematopoiesis (CH) arising from somatic mutations in hematopoietic stem cells (HSCs) is associated with increased risk of developing several…”
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Bone Marrow Stromal Cell Senescence Induced By Dnmt3a-Mutant Hematopoietic Stem and Progenitor Cells Accelerates Clonal Hematopoiesis and Progression to Leukemia by Mistry, Jayna J, Young, Kira A, Trowbridge, Jennifer J

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Bone Marrow Microenvironment and Hematopoietic Cell Types Are Differentially Affected By Transcriptomic Quality Control Filtering Metrics in Single Cell Data by Telpoukhovskaia, Maria A., Young, Kira A., Mistry, Jayna J., Trowbridge, Jennifer J.

“…A crucial step prior to analysis of single cell transcriptomic data includes filtering out low-quality (e.g., dying) cells and artifacts (e.g., empty…”
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Oncostatin M (OSM) Regulates an Inflammatory Cytokine Network in Dnmt3a-Mutant Hematopoietic Stem Cells by Schwartz, Logan Sari, Young, Kira A., Stearns, Tim, Boyer, Nathan, Mujica, Kristina, Trowbridge, Jennifer J.

“…During aging, somatic mutations are known to accumulate in the hematopoietic stem and progenitor cell (HSPC) compartment. While most of these somatic mutations…”
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Robust Mitochondrial Metabolism Provides a Fitness Advantage to Dnmt3a-Mutant Hematopoietic Stem Cells in the Context of Aging by Young, Kira A, Mistry, Jayna J, Chavez, James, Pietras, Eric, Trowbridge, Jennifer J

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Dnmt3a-Mutant Haematopoietic Stem and Progenitor Cells Induce Mesenchymal Stromal Cell Senescence through the Production of Alarmins S100A8/A9 by Mistry, Jayna J., Young, Kira A., Colom Diaz, Patricia, Fernandez Maestre, Ines, Levine, Ross L, Trowbridge, Jennifer J.

“…Clonal haematopoiesis (CH) is an age-related condition occurring due to somatic genetic variation in haematopoietic stem and progenitor cells (HSPCs), most…”
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Reduction in Lymphoid-Supporting Factors By Mesenchymal Stromal Cells Drives Myeloid-Biased Hematopoiesis at Middle Age by Young, Kira A., Telpoukhovskaia, Maria A., Hofmann, Johanna, Kokkaliaris, Konstantinos D., Mistry, Jayna J., Trowbridge, Jennifer J.

“…The bone marrow “niche” for hematopoietic stem cells (HSCs) encompasses various cell types, extracellular matrices and secreted factors that maintain the…”
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