Search Results - "Young, Kaylene"

Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling by Young, Kaylene M., Psachoulia, Konstantina, Tripathi, Richa B., Dunn, Sara-Jane, Cossell, Lee, Attwell, David, Tohyama, Koujiro, Richardson, William D.

“…Oligodendrocyte precursors (OPs) continue to proliferate and generate myelinating oligodendrocytes (OLs) well into adulthood. It is not known whether…”
Get full text

NG2-glia as Multipotent Neural Stem Cells: Fact or Fantasy? by Richardson, William D., Young, Kaylene M., Tripathi, Richa B., McKenzie, Ian

“…Cycling glial precursors—“NG2-glia”—are abundant in the developing and mature central nervous system (CNS). During development, they generate oligodendrocytes…”
Get full text

Low Density Lipoprotein-Receptor Related Protein 1 Is Differentially Expressed by Neuronal and Glial Populations in the Developing and Mature Mouse Central Nervous System by Auderset, Loic, Cullen, Carlie L, Young, Kaylene M

“…The low density lipoprotein-receptor related protein 1 (LRP1) is a large endocytic cell surface receptor that is known to interact with a variety of ligands,…”
Get full text

How does neurovascular unit dysfunction contribute to multiple sclerosis? by Cashion, Jake M., Young, Kaylene M., Sutherland, Brad A.

“…Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system (CNS) and the most common non-traumatic cause of neurological…”
Get full text

Do oligodendrocytes regulate axonal glucose uptake and consumption? by Fletcher, Jessica L., Young, Kaylene M.

“…Neurons have high energy demands. In a recent study, Looser et al. identified oligodendrocyte Kir4.1 as the activity-dependent driver of oligodendrocyte…”
Get full text

Oligodendrogenesis and myelination regulate cortical development, plasticity and circuit function by Fletcher, Jessica L., Makowiecki, Kalina, Cullen, Carlie L., Young, Kaylene M.

“…During cortical development and throughout adulthood, oligodendrocytes add myelin internodes to glutamatergic projection neurons and GABAergic inhibitory…”
Get full text

How Does Transcranial Magnetic Stimulation Influence Glial Cells in the Central Nervous System? by Cullen, Carlie L, Young, Kaylene M

“…Transcranial magnetic stimulation (TMS) is widely used in the clinic, and while it has a direct effect on neuronal excitability, the beneficial effects…”
Get full text

NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease by Tripathi, Richa B, Rivers, Leanne E, Young, Kaylene M, Jamen, Francoise, Richardson, William D

“…The adult mammalian brain and spinal cord contain glial precursors that express platelet-derived growth factor receptor α subunit (PDGFRA) and the NG2…”
Get full text

Subventricular Zone Stem Cells Are Heterogeneous with Respect to Their Embryonic Origins and Neurogenic Fates in the Adult Olfactory Bulb by Young, Kaylene M, Fogarty, Matthew, Kessaris, Nicoletta, Richardson, William D

“…We determined the embryonic origins of adult forebrain subventricular zone (SVZ) stem cells by Cre-lox fate mapping in transgenic mice. We found that all parts…”
Get full text

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice by Rivers, Leanne E, Rizzi, Matteo, Psachoulia, Konstantina, Kessaris, Nicoletta, Wade, Anna, Richardson, William D, Young, Kaylene M, Jamen, Françoise

“…About 4% of the cells in the adult rodent brain are PDGFRA + NG2 + glia, derived from the oligodendrocyte lineage. Rivers and colleagues constructed a…”
Get full text

The regulation of the homeostasis and regeneration of peripheral nerve is distinct from the CNS and independent of a stem cell population by Stierli, Salome, Napoli, Ilaria, White, Ian J, Cattin, Anne-Laure, Monteza Cabrejos, Anthony, Garcia Calavia, Noelia, Malong, Liza, Ribeiro, Sara, Nihouarn, Julie, Williams, Richard, Young, Kaylene M, Richardson, William D, Lloyd, Alison C

“…Peripheral nerves are highly regenerative, in contrast to the poor regenerative capabilities of the central nervous system (CNS). Here, we show that adult…”
Get full text

Properties and fate of oligodendrocyte progenitor cells in the corpus callosum, motor cortex, and piriform cortex of the mouse by Clarke, Laura E, Young, Kaylene M, Hamilton, Nicola B, Li, Huiliang, Richardson, William D, Attwell, David

“…Oligodendrocyte progenitor cells (OPCs) in the postnatal mouse corpus callosum (CC) and motor cortex (Ctx) reportedly generate only oligodendrocytes (OLs),…”
Get full text

Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain by Cullen, Carlie L., Senesi, Matteo, Tang, Alexander D., Clutterbuck, Mackenzie T., Auderset, Loic, O'Rourke, Megan E., Rodger, Jennifer, Young, Kaylene M.

“…Neuronal activity is a potent extrinsic regulator of oligodendrocyte generation and central nervous system myelination. Clinically, repetitive transcranial…”
Get full text

Pathologically mislocalised TDP-43 in upper motor neurons causes a die-forward spread of ALS-like pathogenic changes throughout the mouse corticomotor system by Reale, Laura A., Dyer, Marcus S., Perry, Sharn E., Young, Kaylene M., Dickson, Tracey C., Woodhouse, Adele, Blizzard, Catherine A.

“…Alterations in upper motor neuron excitability are one of the earliest phenomena clinically detected in ALS, and in 97 % of cases, the RNA/DNA binding protein,…”
Get full text

How Do Cells of the Oligodendrocyte Lineage Affect Neuronal Circuits to Influence Motor Function, Memory and Mood? by Pepper, Renee E, Pitman, Kimberley A, Cullen, Carlie L, Young, Kaylene M

“…Oligodendrocyte progenitor cells (OPCs) are immature cells in the central nervous system (CNS) that can rapidly respond to changes within their environment by…”
Get full text

Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain by Cullen, Carlie L., Pepper, Renee E., Clutterbuck, Mackenzie T., Pitman, Kimberley A., Oorschot, Viola, Auderset, Loic, Tang, Alexander D., Ramm, Georg, Emery, Ben, Rodger, Jennifer, Jolivet, Renaud B., Young, Kaylene M.

“…Central nervous system myelination increases action potential conduction velocity. However, it is unclear how myelination is coordinated to ensure the…”
Get full text

Kif3a deletion prevents primary cilia assembly on oligodendrocyte progenitor cells, reduces oligodendrogenesis and impairs fine motor function by Cullen, Carlie L., O'Rourke, Megan, Beasley, Shannon J., Auderset, Loic, Zhen, Yilan, Pepper, Renee E., Gasperini, Robert, Young, Kaylene M.

“…Primary cilia are small microtubule‐based organelles capable of transducing signals from growth factor receptors embedded in the cilia membrane…”
Get full text

STIM1 Is Required for Remodeling of the Endoplasmic Reticulum and Microtubule Cytoskeleton in Steering Growth Cones by Pavez, Macarena, Thompson, Adrian C, Arnott, Hayden J, Mitchell, Camilla B, D'Atri, Ilaria, Don, Emily K, Chilton, John K, Scott, Ethan K, Lin, John Y, Young, Kaylene M, Gasperini, Robert J, Foa, Lisa

“…The spatial and temporal regulation of calcium signaling in neuronal growth cones is essential for axon guidance. In growth cones, the endoplasmic reticulum…”
Get full text

How does calcium interact with the cytoskeleton to regulate growth cone motility during axon pathfinding? by Gasperini, Robert J., Pavez, Macarena, Thompson, Adrian C., Mitchell, Camilla B., Hardy, Holly, Young, Kaylene M., Chilton, John K., Foa, Lisa

“…The precision with which neurons form connections is crucial for the normal development and function of the nervous system. The development of neuronal…”
Get full text

Oligodendrogenesis increases in hippocampal grey and white matter prior to locomotor or memory impairment in an adult mouse model of tauopathy by Ferreira, Solène, Pitman, Kimberley A., Summers, Benjamin S., Wang, Shiwei, Young, Kaylene M., Cullen, Carlie L.

“…Myelin and axon losses are associated with cognitive decline in healthy ageing but are worse in people diagnosed with tauopathy. To determine whether tauopathy…”
Get full text