Search Results - "Young, John A.T"

Anthrax toxin: receptor binding, internalization, pore formation, and translocation by Young, John A T, Collier, R John

“…Anthrax toxin consists of three nontoxic proteins that self-assemble at the surface of receptor-bearing mammalian cells or in solution, yielding a series of…”
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ANTHRAX TOXIN by Collier, R. John, Young, John A.T

“…Anthrax toxin consists of three nontoxic proteins that associate in binary or ternary combinations to form toxic complexes at the surface of mammalian cells…”
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HBVcircle: A novel tool to investigate hepatitis B virus covalently closed circular DNA by Yan, Zhipeng, Zeng, Jing, Yu, Youjun, Xiang, Kunlun, Hu, Hui, Zhou, Xue, Gu, Lili, Wang, Li, Zhao, Jie, Young, John A.T, Gao, Lu

“…Graphical abstract…”
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Enveloped Viruses Disable Innate Immune Responses in Dendritic Cells by Direct Activation of TAM Receptors by Bhattacharyya, Suchita, Zagórska, Anna, Lew, Erin D., Shrestha, Bimmi, Rothlin, Carla V., Naughton, John, Diamond, Michael S., Lemke, Greg, Young, John A.T.

“…Upon activation by the ligands Gas6 and Protein S, Tyro3/Axl/Mer (TAM) receptor tyrosine kinases promote phagocytic clearance of apoptotic cells and…”
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Monosynaptic Restriction of Transsynaptic Tracing from Single, Genetically Targeted Neurons by Wickersham, Ian R., Lyon, David C., Barnard, Richard J.O., Mori, Takuma, Finke, Stefan, Conzelmann, Karl-Klaus, Young, John A.T., Callaway, Edward M.

“…There has never been a wholesale way of identifying neurons that are monosynaptically connected either to some other cell group or, especially, to a single…”
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CAR1, a TNFR–Related Protein, Is a Cellular Receptor for Cytopathic Avian Leukosis–Sarcoma Viruses and Mediates Apoptosis by Brojatsch, Jürgen, Naughton, John, Rolls, Melissa M, Zingler, Kurt, Young, John A.T

“…Viral envelope (Env)–receptor interactions have been implicated in the cell death associated with infection by subgroups B and D avian leukosis–sarcoma viruses…”
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Discovery of a first-in-class orally available HBV cccDNA inhibitor by Wang, Li, Zhu, Qihui, Zhang, Jitao David, Zhang, Yaling, Ni, Xiaoju, Xiang, Kunlun, Jiang, Jiaxi, Li, Baocun, Yu, Youjun, Hu, Hui, Zhang, Meifang, Wu, Waikwong, Zeng, Jing, Yan, Zhipeng, Dai, Jieyu, Sun, Kai, Zhang, Xin, Chen, Dongdong, Feng, Song, Sach-Peltason, Lisa, Young, John A.T., Gao, Lu

“…The persistence of covalently closed circular DNA (cccDNA) in infected hepatocytes is the major barrier preventing viral eradication with existing therapies in…”
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Human host factors required for influenza virus replication by Shaw, Megan L, Chanda, Sumit K, König, Renate, Stertz, Silke, Zhou, Yingyao, Inoue, Atsushi, Hoffmann, H. -Heinrich, Bhattacharyya, Suchita, Alamares, Judith G, Tscherne, Donna M, Ortigoza, Mila B, Liang, Yuhong, Gao, Qinshan, Andrews, Shane E, Bandyopadhyay, Sourav, De Jesus, Paul, Tu, Buu P, Pache, Lars, Shih, Crystal, Orth, Anthony, Bonamy, Ghislain, Miraglia, Loren, Ideker, Trey, García-Sastre, Adolfo, Young, John A. T, Palese, Peter

“…Influenza A virus is an RNA virus that encodes up to 11 proteins and this small coding capacity demands that the virus use the host cellular machinery for many…”
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BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency by Pache, Lars, Dutra, Miriam S., Spivak, Adam M., Marlett, John M., Murry, Jeffrey P., Hwang, Young, Maestre, Ana M., Manganaro, Lara, Vamos, Mitchell, Teriete, Peter, Martins, Laura J., König, Renate, Simon, Viviana, Bosque, Alberto, Fernandez-Sesma, Ana, Cosford, Nicholas D.P., Bushman, Frederic D., Young, John A.T., Planelles, Vicente, Chanda, Sumit K.

“…Combination antiretroviral therapy (ART) is able to suppress HIV-1 replication to undetectable levels. However, the persistence of latent viral reservoirs…”
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The hr1 and fusion peptide regions of the subgroup B avian sarcoma and leukosis virus envelope glycoprotein influence low pH-dependent membrane fusion by Babel, Angeline Rose, Bruce, James, Young, John A T

“…The avian sarcoma and leukosis virus (ASLV) envelope glycoprotein (Env) is activated to trigger fusion by a two-step mechanism involving receptor-priming and…”
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Host cell factors in HIV replication: meta-analysis of genome-wide studies by Bushman, Frederic D, Malani, Nirav, Fernandes, Jason, D'Orso, Iván, Cagney, Gerard, Diamond, Tracy L, Zhou, Honglin, Hazuda, Daria J, Espeseth, Amy S, König, Renate, Bandyopadhyay, Sourav, Ideker, Trey, Goff, Stephen P, Krogan, Nevan J, Frankel, Alan D, Young, John A T, Chanda, Sumit K

“…We have analyzed host cell genes linked to HIV replication that were identified in nine genome-wide studies, including three independent siRNA screens…”
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HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2 by Ocwieja, Karen E, Brady, Troy L, Ronen, Keshet, Huegel, Alyssa, Roth, Shoshannah L, Schaller, Torsten, James, Leo C, Towers, Greg J, Young, John A T, Chanda, Sumit K, König, Renate, Malani, Nirav, Berry, Charles C, Bushman, Frederic D

“…Genome-wide siRNA screens have identified host cell factors important for efficient HIV infection, among which are nuclear pore proteins such as RanBP2/Nup358…”
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Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis by Miller, Matthew S, Rialdi, Alexander, Ho, Jessica Sook Yuin, Tilove, Micah, Martinez-Gil, Luis, Moshkina, Natasha P, Peralta, Zuleyma, Noel, Justine, Melegari, Camilla, Maestre, Ana M, Mitsopoulos, Panagiotis, Madrenas, Joaquín, Heinz, Sven, Benner, Chris, Young, John A T, Feagins, Alicia R, Basler, Christopher F, Fernandez-Sesma, Ana, Becherel, Olivier J, Lavin, Martin F, van Bakel, Harm, Marazzi, Ivan

“…Mutations in the gene encoding the helicase senataxin have well established associations with the neurodegenerative disease ALS. Marazzi et al . show that…”
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Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo by Javanbakht, Hassan, Mueller, Henrik, Walther, Johanna, Zhou, Xue, Lopez, Anaïs, Pattupara, Thushara, Blaising, Julie, Pedersen, Lykke, Albæk, Nanna, Jackerott, Malene, Shi, Tianlai, Ploix, Corinne, Driessen, Wouter, Persson, Robert, Ravn, Jacob, Young, John A.T., Ottosen, Søren

“…Chronic hepatitis B infection (CHB) is an area of high unmet medical need. Current standard-of-care therapies only rarely lead to a functional cure, defined as…”
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Differential requirements for clathrin endocytic pathway components in cellular entry by Ebola and Marburg glycoprotein pseudovirions by Bhattacharyya, Suchita, Hope, Thomas J, Young, John A.T

“…Abstract Clathrin-mediated endocytosis was previously implicated as one of the cellular pathways involved in filoviral glycoprotein mediated viral entry into…”
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Imaging single retrovirus entry through alternative receptor isoforms and intermediates of virus-endosome fusion by Jha, Naveen K, Latinovic, Olga, Martin, Erik, Novitskiy, Gennadiy, Marin, Mariana, Miyauchi, Kosuke, Naughton, John, Young, John A T, Melikyan, Gregory B

“…A large group of viruses rely on low pH to activate their fusion proteins that merge the viral envelope with an endosomal membrane, releasing the viral…”
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Efficacy of an Inhibitor of Hepatitis B Virus Expression in Combination With Entecavir and Interferon‐α in Woodchucks Chronically Infected With Woodchuck Hepatitis Virus by Menne, Stephan, Wildum, Steffen, Steiner, Guido, Suresh, Manasa, Korolowicz, Kyle, Balarezo, Maria, Yon, Changsuek, Murreddu, Marta, Hong, Xupeng, Kallakury, Bhaskar V., Tucker, Robin, Yang, Song, Young, John A.T., Javanbakht, Hassan

“…RG7834 is a small‐molecule inhibitor of hepatitis B virus (HBV) gene expression that significantly reduces the levels of hepatitis B surface antigen (HBsAg)…”
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ZASC1 stimulates HIV-1 transcription elongation by recruiting P-TEFb and TAT to the LTR promoter by Bruce, James W, Reddington, Rachel, Mathieu, Elizabeth, Bracken, Megan, Young, John A T, Ahlquist, Paul

“…Transcription from the HIV-1 LTR promoter efficiently initiates but rapidly terminates because of a non-processive form of RNA polymerase II. This premature…”
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Sulfonation pathway inhibitors block reactivation of latent HIV-1 by Murry, Jeffrey P, Godoy, Joseph, Mukim, Amey, Swann, Justine, Bruce, James W, Ahlquist, Paul, Bosque, Alberto, Planelles, Vicente, Spina, Celsa A, Young, John A.T

“…Abstract Long-lived pools of latently infected cells are a significant barrier to the development of a cure for HIV-1 infection. A better understanding of the…”
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Retroviral Entry Mediated by Receptor Priming and Low pH Triggering of an Envelope Glycoprotein by Mothes, Walther, Boerger, Adrienne L., Narayan, Shakti, Cunningham, James M., Young, John A.T.

“…Avian leukosis virus (ALV) has been used as a model system to understand the mechanism of pH-independent viral entry involving receptor-induced conformational…”
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