Search Results - "Young, John A. T."

HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2 by Ocwieja, Karen E, Brady, Troy L, Ronen, Keshet, Huegel, Alyssa, Roth, Shoshannah L, Schaller, Torsten, James, Leo C, Towers, Greg J, Young, John A T, Chanda, Sumit K, König, Renate, Malani, Nirav, Berry, Charles C, Bushman, Frederic D

“…Genome-wide siRNA screens have identified host cell factors important for efficient HIV infection, among which are nuclear pore proteins such as RanBP2/Nup358…”
Get full text

Host cell factors in HIV replication: meta-analysis of genome-wide studies by Bushman, Frederic D, Malani, Nirav, Fernandes, Jason, D'Orso, Iván, Cagney, Gerard, Diamond, Tracy L, Zhou, Honglin, Hazuda, Daria J, Espeseth, Amy S, König, Renate, Bandyopadhyay, Sourav, Ideker, Trey, Goff, Stephen P, Krogan, Nevan J, Frankel, Alan D, Young, John A T, Chanda, Sumit K

“…We have analyzed host cell genes linked to HIV replication that were identified in nine genome-wide studies, including three independent siRNA screens…”
Get full text

Identification of the cellular receptor for anthrax toxin by Young, John A. T, Bradley, Kenneth A, Mogridge, Jeremy, Mourez, Michael, Collier, R. John

“…The tripartite toxin secreted by Bacillus anthracis, the causative agent of anthrax, helps the bacterium evade the immune system and can kill the host during a…”
Get full text

Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity by Reeves, Claire V, Wang, Xing, Charles-Horvath, Pelisa C, Vink, Joy Y, Borisenko, Valeriya Y, Young, John A T, Kitajewski, Jan K

“…Anthrax Toxin Receptor proteins function as receptors for anthrax toxin, however physiological activity remains unclear. To evaluate the biological role of…”
Get full text

Discovery of Small Molecule Therapeutics for Treatment of Chronic HBV Infection by Feng, Song, Gao, Lu, Han, Xingchun, Hu, Taishan, Hu, Yimin, Liu, Haixia, Thomas, Andrew W, Yan, Zhipeng, Yang, Song, Young, John A. T, Yun, Hongying, Zhu, Wei, Shen, Hong C

“…The chronic infection of hepatitis B virus (HBV) inflicts 250 million people worldwide representing a major public health threat. A significant subpopulation…”
Get full text

Imaging single retrovirus entry through alternative receptor isoforms and intermediates of virus-endosome fusion by Jha, Naveen K, Latinovic, Olga, Martin, Erik, Novitskiy, Gennadiy, Marin, Mariana, Miyauchi, Kosuke, Naughton, John, Young, John A T, Melikyan, Gregory B

“…A large group of viruses rely on low pH to activate their fusion proteins that merge the viral envelope with an endosomal membrane, releasing the viral…”
Get full text

HIV-1: Fifteen Proteins and an RNA by Frankel, Alan D, Young, John A. T

“…Human immunodeficiency virus type 1 is a complex retrovirus encoding 15 distinct proteins. Substantial progress has been made toward understanding the function…”
Get full text

An integrated map of HIV-human protein complexes that facilitate viral infection by Emig-Agius, Dorothea, Olivieri, Kevin, Pache, Lars, Shih, Hsin Ling, Pustovalova, Olga, Bessarabova, Marina, Young, John A T, Chanda, Sumit K, Ideker, Trey

“…Recent proteomic and genetic studies have aimed to identify a complete network of interactions between HIV and human proteins and genes. This HIV-human…”
Get full text

A viral nanoparticle with dual function as an anthrax antitoxin and vaccine by Manayani, Darly J, Thomas, Diane, Dryden, Kelly A, Reddy, Vijay, Siladi, Marc E, Marlett, John M, Rainey, G Jonah A, Pique, Michael E, Scobie, Heather M, Yeager, Mark, Young, John A T, Manchester, Marianne, Schneemann, Anette

“…The recent use of Bacillus anthracis as a bioweapon has stimulated the search for novel antitoxins and vaccines that act rapidly and with minimal adverse…”
Get full text

Delayed toxicity associated with soluble anthrax toxin receptor decoy-Ig fusion protein treatment by Thomas, Diane, Naughton, John, Cote, Christopher, Welkos, Susan, Manchester, Marianne, Young, John A T

“…Soluble receptor decoy inhibitors, including receptor-immunogloubulin (Ig) fusion proteins, have shown promise as candidate anthrax toxin therapeutics. These…”
Get full text

Efficient Neutralization of Antibody-Resistant Forms of Anthrax Toxin by a Soluble Receptor Decoy Inhibitor by SHARMA, Shilpi, THOMAS, Diane, MARLETT, John, MANCHESTER, Marianne, YOUNG, John A. T

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Selective viral vector transduction of ErbB4 expressing cortical interneurons in vivo with a viral receptor—ligand bridge protein by Choi, Jiwon, Young, John A. T., Callaway, Edward M.

“…Both treatment of disease and basic studies of complex tissues can benefit from directing viral vector infection to specific cell types. We have used a unique…”
Get full text

Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms by Zhou, Zheng, Hu, Taishan, Zhou, Xue, Wildum, Steffen, Garcia-Alcalde, Fernando, Xu, Zhiheng, Wu, Daitze, Mao, Yi, Tian, Xiaojun, Zhou, Yuan, Shen, Fang, Zhang, Zhisen, Tang, Guozhi, Najera, Isabel, Yang, Guang, Shen, Hong C., Young, John A. T., Qin, Ning

“…Heteroaryldihydropyrimidine (HAP) and sulfamoylbenzamide (SBA) are promising non-nucleos(t)ide HBV replication inhibitors. HAPs are known to promote core…”
Get full text

Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes by Zeng, Jing, Wu, Daitze, Hu, Hui, Young, John A.T., Yan, Zhipeng, Gao, Lu

“…Background and Aims Hepatitis B virus (HBV) infection is ranked among the top health priorities worldwide. Accumulating evidence suggests that HBV infection…”
Get full text

A receptor-based switch that regulates anthrax toxin pore formation by Pilpa, Rosemarie M, Bayrhuber, Monika, Marlett, John M, Riek, Roland, Young, John A T

“…Cellular receptors can act as molecular switches, regulating the sensitivity of microbial proteins to conformational changes that promote cellular entry. The…”
Get full text

Human host factors required for influenza virus replication by Shaw, Megan L, Chanda, Sumit K, König, Renate, Stertz, Silke, Zhou, Yingyao, Inoue, Atsushi, Hoffmann, H. -Heinrich, Bhattacharyya, Suchita, Alamares, Judith G, Tscherne, Donna M, Ortigoza, Mila B, Liang, Yuhong, Gao, Qinshan, Andrews, Shane E, Bandyopadhyay, Sourav, De Jesus, Paul, Tu, Buu P, Pache, Lars, Shih, Crystal, Orth, Anthony, Bonamy, Ghislain, Miraglia, Loren, Ideker, Trey, García-Sastre, Adolfo, Young, John A. T, Palese, Peter

“…Influenza A virus is an RNA virus that encodes up to 11 proteins and this small coding capacity demands that the virus use the host cellular machinery for many…”
Get full text

HBVcircle: A novel tool to investigate hepatitis B virus covalently closed circular DNA by Yan, Zhipeng, Zeng, Jing, Yu, Youjun, Xiang, Kunlun, Hu, Hui, Zhou, Xue, Gu, Lili, Wang, Li, Zhao, Jie, Young, John A.T, Gao, Lu

“…Graphical abstract…”
Get full text

Receptor-Specific Requirements for Anthrax Toxin Delivery into Cells by G. Jonah A. Rainey, Wigelsworth, Darran J., Ryan, Patricia L., Scobie, Heather M., Collier, R. John, John A. T. Young

“…The three proteins that constitute anthrax toxin self-assemble into toxic complexes after one of these proteins, protective antigen (PA), binds to tumor…”
Get full text

PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization by Mueller, Henrik, Lopez, Anaïs, Tropberger, Philipp, Wildum, Steffen, Schmaler, Josephine, Pedersen, Lykke, Han, Xingchun, Wang, Yongguang, Ottosen, Søren, Yang, Song, Young, John A.T., Javanbakht, Hassan

“…RG7834 is a potent, orally bioavailable small‐molecule inhibitor of hepatitis B virus (HBV) gene expression that belongs to the dihydroquinolizinone (DHQ)…”
Get full text

Cellular Transcription Factor ZASC1 Regulates Murine Leukemia Virus Transcription by Bruce, James W, Hierl, Michael, Young, John A T, Ahlquist, Paul

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text