Search Results - "Young, Jacques"

Prolactin — a pleiotropic factor in health and disease by Bernard, Valérie, Young, Jacques, Binart, Nadine

“…The principal role of prolactin in mammals is the regulation of lactation. Prolactin is a hormone that is mainly synthesized and secreted by lactotroph cells…”
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New insights in prolactin: pathological implications by Bernard, Valérie, Young, Jacques, Chanson, Philippe, Binart, Nadine

“…Key Points The major 23 kDa prolactin isoform exerts its action via a transmembrane receptor, prolactin receptor (PRL-R), which belongs to the class of…”
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MANAGEMENT OF ENDOCRINE DISEASE: Cushing’s syndrome due to ectopic ACTH secretion: an expert operational opinion by Young, Jacques, Haissaguerre, Magalie, Viera-Pinto, Oceana, Chabre, Olivier, Baudin, Eric, Tabarin, Antoine

“…Ectopic ACTH syndrome (EAS) is rare but is frequently a severe condition because of the intensity of the hypercortisolism that may be dissociated from the…”
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Clinical Management of Congenital Hypogonadotropic Hypogonadism by Young, Jacques, Xu, Cheng, Papadakis, Georgios E, Acierno, James S, Maione, Luigi, Hietamäki, Johanna, Raivio, Taneli, Pitteloud, Nelly

“…Abstract The initiation and maintenance of reproductive capacity in humans is dependent on pulsatile secretion of the hypothalamic hormone GnRH. Congenital…”
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Non-invasive Diagnostic Strategy in ACTH-dependent Cushing’s Syndrome by Frete, Caroline, Corcuff, Jean-Benoît, Kuhn, Emmanuelle, Salenave, Sylvie, Gaye, Delphine, Young, Jacques, Chanson, Philippe, Tabarin, Antoine

“…Abstract Context Inferior petrosal sinus sampling (IPSS) is used to diagnose Cushing’s disease (CD) when dexamethasone-suppression and CRH tests, and pituitary…”
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Treatment of acromegaly has substantial effects on body composition: a long-term follow-up study by Wolf, Peter, Salenave, Sylvie, Durand, Emmanuel, Young, Jacques, Kamenicky, Peter, Chanson, Philippe, Maione, Luigi

“…Background Acromegaly is associated with changes in body composition. Long-term changes following acromegaly treatment and the impact of different treatments…”
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ATG7 and ATG9A loss-of-function variants trigger autophagy impairment and ovarian failure by Delcour, Clémence, Amazit, Larbi, Patino, Liliana C., Magnin, Françoise, Fagart, Jérôme, Delemer, Brigitte, Young, Jacques, Laissue, Paul, Binart, Nadine, Beau, Isabelle

“…Purpose Primary ovarian insufficiency (POI) is a frequent disorder that affects ~1% of women under 40 years of age. POI, which is characterized by the…”
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Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration by Sonigo, Charlotte, Bouilly, Justine, Carré, Nadège, Tolle, Virginie, Caraty, Alain, Tello, Javier, Simony-Conesa, Fabian-Jesus, Millar, Robert, Young, Jacques, Binart, Nadine

“…Hyperprolactinemia is the most common cause of hypogonadotropic anovulation and is one of the leading causes of infertility in women aged 25-34…”
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Female Gonadal Function before and after Treatment of Acromegaly by Grynberg, Michaël, Salenave, Sylvie, Young, Jacques, Chanson, Philippe

“…Context: The menstrual cycle is often abnormal in women with acromegaly. Gonadotropin deficiency may be due to a tumor mass effect (macroadenomas) and/or…”
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X-linked acrogigantism syndrome: clinical profile and therapeutic responses by Beckers, Albert, Lodish, Maya Beth, Trivellin, Giampaolo, Rostomyan, Liliya, Lee, Misu, Faucz, Fabio R, Yuan, Bo, Choong, Catherine S, Caberg, Jean-Hubert, Verrua, Elisa, Naves, Luciana Ansaneli, Cheetham, Tim D, Young, Jacques, Lysy, Philippe A, Petrossians, Patrick, Cotterill, Andrew, Shah, Nalini Samir, Metzger, Daniel, Castermans, Emilie, Ambrosio, Maria Rosaria, Villa, Chiara, Strebkova, Natalia, Mazerkina, Nadia, Gaillard, Stéphan, Barra, Gustavo Barcelos, Casulari, Luis Augusto, Neggers, Sebastian J, Salvatori, Roberto, Jaffrain-Rea, Marie-Lise, Zacharin, Margaret, Santamaria, Beatriz Lecumberri, Zacharieva, Sabina, Lim, Ee Mun, Mantovani, Giovanna, Zatelli, Maria Chaira, Collins, Michael T, Bonneville, Jean-François, Quezado, Martha, Chittiboina, Prashant, Oldfield, Edward H, Bours, Vincent, Liu, Pengfei, de Herder, Wouter W, Pellegata, Natalia, Lupski, James R, Daly, Adrian F, Stratakis, Constantine A

“…X-linked acrogigantism (X-LAG) is a new syndrome of pituitary gigantism, caused by microduplications on chromosome Xq26.3, encompassing the gene GPR101, which…”
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Germline AIP Mutations in Apparently Sporadic Pituitary Adenomas: Prevalence in a Prospective Single-Center Cohort of 443 Patients by Cazabat, Laure, Bouligand, Jérôme, Salenave, Sylvie, Bernier, Michèle, Gaillard, Stephan, Parker, Fabrice, Young, Jacques, Guiochon-Mantel, Anne, Chanson, Philippe

“…Context: Germline mutations of the AIP (aryl-hydrocarbon receptor interacting protein) gene are associated with a predisposition to pituitary adenomas. Such…”
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GnRH stimulation testing and serum inhibin B in males: insufficient specificity for discriminating between congenital hypogonadotropic hypogonadism from constitutional delay of growth and puberty by Mosbah, Héléna, Bouvattier, Claire, Maione, Luigi, Trabado, Séverine, De Filippo, Gianpaolo, Cartes, Alejandra, Donzeau, Aurélie, Chanson, Philippe, Brailly-Tabard, Sylvie, Dwyer, Andrew A, Coutant, Régis, Young, Jacques

“…Abstract STUDY QUESTION Are GnRH tests and serum inhibin B levels sufficiently discriminating to distinguish transient constitutional delay of growth and…”
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SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome by Hanchate, Naresh Kumar, Giacobini, Paolo, Lhuillier, Pierre, Parkash, Jyoti, Espy, Cécile, Fouveaut, Corinne, Leroy, Chrystel, Baron, Stéphanie, Campagne, Céline, Vanacker, Charlotte, Collier, Francis, Cruaud, Corinne, Meyer, Vincent, García-Piñero, Alfons, Dewailly, Didier, Cortet-Rudelli, Christine, Gersak, Ksenija, Metz, Chantal, Chabrier, Gérard, Pugeat, Michel, Young, Jacques, Hardelin, Jean-Pierre, Prevot, Vincent, Dodé, Catherine

“…Kallmann syndrome (KS) associates congenital hypogonadism due to gonadotropin-releasing hormone (GnRH) deficiency and anosmia. The genetics of KS involves…”
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Factors predicting relapse of nonfunctioning pituitary macroadenomas after neurosurgery: a study of 142 patients by Brochier, Sophie, Galland, Françoise, Kujas, Michèle, Parker, Fabrice, Gaillard, Stephan, Raftopoulos, Christian, Young, Jacques, Alexopoulou, Orsalia, Maiter, Dominique, Chanson, Philippe

“…ContextAdequate postoperative management of nonfunctioning pituitary macroadenomas (NFMAs) remains a challenge for the clinician.ObjectiveTo identify…”
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IGSF10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty by Howard, Sasha R, Guasti, Leonardo, Ruiz‐Babot, Gerard, Mancini, Alessandra, David, Alessia, Storr, Helen L, Metherell, Lousie A, Sternberg, Michael JE, Cabrera, Claudia P, Warren, Helen R, Barnes, Michael R, Quinton, Richard, de Roux, Nicolas, Young, Jacques, Guiochon‐Mantel, Anne, Wehkalampi, Karoliina, André, Valentina, Gothilf, Yoav, Cariboni, Anna, Dunkel, Leo

“…Early or late pubertal onset affects up to 5% of adolescents and is associated with adverse health and psychosocial outcomes. Self‐limited delayed puberty (DP)…”
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Lack of Androgen Receptor Expression in Sertoli Cells Accounts for the Absence of Anti-Mullerian Hormone Repression during Early Human Testis Development by Boukari, Kahina, Meduri, Geri, Brailly-Tabard, Sylvie, Guibourdenche, Jean, Ciampi, Maria Luisa, Massin, Nathalie, Martinerie, Laetitia, Picard, Jean-Yves, Rey, Rodolfo, Lombès, Marc, Young, Jacques

“…Context: Puberty is associated with increased testicular testosterone (TT) synthesis, which is required to trigger spermatogenesis and to repress…”
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Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2 by Dodé, Catherine, Teixeira, Luis, Levilliers, Jacqueline, Fouveaut, Corinne, Bouchard, Philippe, Kottler, Marie-Laure, Lespinasse, James, Lienhardt-Roussie, Anne, Mathieu, Michèle, Moerman, Alexandre, Morgan, Graeme, Murat, Arnaud, Toublanc, Jean-Edmont, Wolczynski, Slawomir, Delpech, Marc, Petit, Christine, Young, Jacques, Hardelin, Jean-Pierre

“…Kallmann syndrome combines anosmia, related to defective olfactory bulb morphogenesis, and hypogonadism due to gonadotropin-releasing hormone deficiency…”
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Evidence for DNA-Binding Domain–Ligand-Binding Domain Communications in the Androgen Receptor by Helsen, Christine, Dubois, Vanessa, Verfaillie, Annelien, Young, Jacques, Trekels, Mieke, Vancraenenbroeck, Renée, De Maeyer, Marc, Claessens, Frank

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Normosmic congenital hypogonadotropic hypogonadism due to TAC3/TACR3 mutations: characterization of neuroendocrine phenotypes and novel mutations by Francou, Bruno, Bouligand, Jérôme, Voican, Adela, Amazit, Larbi, Trabado, Séverine, Fagart, Jérôme, Meduri, Geri, Brailly-Tabard, Sylvie, Chanson, Philippe, Lecomte, Pierre, Guiochon-Mantel, Anne, Young, Jacques

“…TAC3/TACR3 mutations have been reported in normosmic congenital hypogonadotropic hypogonadism (nCHH) (OMIM #146110). In the absence of animal models, studies…”
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Acromegaly by Chanson, Philippe, MD, Salenave, Sylvie, MD, Kamenicky, Peter, MD, PhD, Cazabat, Laure, MD, Young, Jacques, MD, PhD

“…Excessive production of the growth hormone (GH) is responsible for acromegaly. It is related to a pituitary GH-secreting adenoma in most cases. Prevalence is…”
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