Search Results - "Young, Erick"

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    Novel cross-talk within the IKK family controls innate immunity by Clark, Kristopher, Peggie, Mark, Plater, Lorna, Sorcek, Ronald J, Young, Erick R R, Madwed, Jeffrey B, Hough, Joanne, McIver, Edward G, Cohen, Philip

    Published in Biochemical journal (15-02-2011)
    “…Members of the IKK {IκB [inhibitor of NF-κB (nuclear factor κB)] kinase} family play a central role in innate immunity by inducing NF-κB- and IRF [IFN…”
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    Journal Article
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    Temporal Regulation of the Bacterial Metabolite Deoxycholate during Colonic Repair Is Critical for Crypt Regeneration by Jain, Umang, Lai, Chin-Wen, Xiong, Shanshan, Goodwin, Victoria M., Lu, Qiuhe, Muegge, Brian D., Christophi, George P., VanDussen, Kelli L., Cummings, Bethany P., Young, Erick, Hambor, John, Stappenbeck, Thaddeus S.

    Published in Cell host & microbe (12-09-2018)
    “…Colonic wound repair is an orchestrated process, beginning with barrier re-establishment and followed by wound channel formation and crypt regeneration…”
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    Journal Article
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    Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 3, aryl substituted pyrrolidines by Bosanac, Todd, Hickey, Eugene R., Ginn, John, Kashem, Mohammed, Kerr, Steven, Kugler, Stanley, Li, Xiang, Olague, Alan, Schlyer, Sabine, Young, Erick R.R.

    Published in Bioorganic & medicinal chemistry letters (15-06-2010)
    “…The discovery and SAR of a series of β-aryl substituted pyrrolidine 2H-isoquinolin-1-one inhibitors of Rho-kinase (ROCK) derived from 2 is herein described…”
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    Journal Article
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    Essential Role for IKKβ in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells by Pauls, Eduardo, Shpiro, Natalia, Peggie, Mark, Young, Erick R., Sorcek, Ronald J., Tan, Li, Choi, Hwan Geun, Cohen, Philip

    Published in The Journal of biological chemistry (01-06-2012)
    “…Plasmacytoid dendritic cells (pDCs) are characterized by their ability to produce high levels of type 1 interferons in response to ligands that activate TLR7…”
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    Journal Article
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