Search Results - "Young, Debra A"

Characterization of LY3023414, a Novel PI3K/mTOR Dual Inhibitor Eliciting Transient Target Modulation to Impede Tumor Growth by Smith, Michele C, Mader, Mary M, Cook, James A, Iversen, Philip, Ajamie, Rose, Perkins, Everett, Bloem, Laura, Yip, Yvonne Y, Barda, David A, Waid, Philip P, Zeckner, Douglas J, Young, Debra A, Sanchez-Felix, Manuel, Donoho, Gregory P, Wacheck, Volker

“…The PI3K/AKT/mTOR pathway is among the most frequently altered pathways in cancer cell growth and survival. LY3023414 is a complex fused imidazoquinolinone…”
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Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications by Tan, Bo, Young, Debra A, Lu, Zhao-Hai, Wang, Tao, Meier, Timothy I, Shepard, Robert L, Roth, Kenneth, Zhai, Yan, Huss, Karen, Kuo, Ming-Shang, Gillig, James, Parthasarathy, Saravanan, Burkholder, Timothy P, Smith, Michele C, Geeganage, Sandaruwan, Zhao, Genshi

“…Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the first rate-limiting step in converting nicotinamide to NAD(+), essential for cellular metabolism,…”
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Syringomycin E Inhibition of Saccharomyces cerevisiae: Requirement for Biosynthesis of Sphingolipids with Very-Long-Chain Fatty Acids and Mannose- and Phosphoinositol-Containing Head Groups by STOCK, S. D, HAMA, H, RADDING, J. A, YOUNG, D. A, TAKEMOTO, J. Y

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, in Human Cancer Cells by Tan, Bo, Young, Debra A., Lu, Zhao-Hai, Wang, Tao, Meier, Timothy I., Shepard, Robert L., Roth, Kenneth, Zhai, Yan, Huss, Karen, Kuo, Ming-Shang, Gillig, James, Parthasarathy, Saravanan, Burkholder, Timothy P., Smith, Michele C., Geeganage, Sandaruwan, Zhao, Genshi

“…Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the first rate-limiting step in converting nicotinamide to NAD+, essential for cellular metabolism,…”
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Abstract 5245: Identification and characterization of the IDO1 inhibitor LY3381916 by Dorsey, Frank C., Benhadji, Karim A., Sams, Lillian L., Young, Debra A., Schindler, John F., Huss, Karen L., Nikolayev, Alexander, Carpenito, Carmine, Clawson, David, Jones, Bonita, Faber, Andrew L., Thomas, James E., Haney, Steven A., Zhao, Gaiying, McMillen, William T., Smeal, Tod, Sall, Daniel J., Kalos, Michael D., Geeganage, Sandaruwan, Henry, James R.

“…Abstract Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-dependent enzyme that catalyzes the initial and rate-limiting step of tryptophan catabolism resulting…”
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Requirement of sphingolipid α-hydroxylation for fungicidal action of syringomycin E by Hama, Hiroko, Young, Debra A., Radding, Jeffrey A., Ma, Doreen, Tang, Julia, Stock, Stephen D., Takemoto, Jon Y.

“…Syringomycin E is an antifungal cyclic lipodepsinonapeptide produced by Pseudomonas syringae pv. syringae. To understand the mechanism of action of…”
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Genetic analysis of functional differences among distinct ferredoxins in Rhodobacter capsulatus by SAEKI, K, SUETSUGU, Y, TOKUDA, K.-I, MIYATAKE, Y, YOUNG, D. A, MARRS, B. L, MATMSUBARA, H

“…Rhodobacter capsulatus has been known to possess two ferredoxins (I and II) with distinct physicochemical and structural properties: ferredoxin I is a…”
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A plant-ferredoxin-like gene is located upstream of ferredoxin I gene (fdxN) of Rhodobacter capsulatus by SAEKI, K, MIYATAKE, Y, YOUNG, D. A, MARRS, B. L, MATSUBARA, H

“…The gene encoding the ferredoxin I (fdxN ) of the Rhodobacter capsulatus SB1003 was obtained by screening a Lorist2 cosmid library using an oligonucleotide…”
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Sequence of the indoleglycerol phosphate synthase (trpC) gene from Rhodobacter capsulatus by BECKER-RUDZIK, M, YOUNG, D. A, MARRS, B. L

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Effect of Altered Lipid A Synthesis on the Synthesis of Major Proteins of the Salmonella typhimurium Outer Membrane by Rick, P D, Neumeyer, B A, Young, D A

“…The effect of altered lipid A synthesis on the synthesis of major outer membrane proteins was investigated in mutants of Salmonella typhimurium conditionally…”
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