Search Results - "Young, David C"
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1
Computational drug design: a guide for computational and medicinal Chemists
Published 2009“…A solid perspective on the entire breadth of the field of computational drug design, including every major design technique in use today Explains how the drug…”
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Correction: Oral misoprostol, low dose vaginal misoprostol, and vaginal dinoprostone for labor induction: Randomized controlled trial
Published in PloS one (20-05-2024)“…[This corrects the article DOI: 10.1371/journal.pone.0227245.]…”
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Oral misoprostol, low dose vaginal misoprostol, and vaginal dinoprostone for labor induction: Randomized controlled trial
Published in PloS one (01-01-2020)“…To compare effectiveness and safety of oral misoprostol (50 μg every four hours as needed), low dose vaginal misoprostol (25 to 50 μg every six hours as…”
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Incremental net monetary benefit of biologic therapies in moderate to severe asthma: a systematic review and meta-analysis of economic evaluation studies
Published in The Journal of asthma (02-09-2023)“…This meta-analysis was conducted to quantitatively pool the incremental net benefit (INB) of using biologic therapies as an add-on treatment to standard…”
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A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis
Published in Nature communications (26-04-2022)“…Iron is essential for growth of Mycobacterium tuberculosis , the causative agent of tuberculosis. To acquire iron from the host, M. tuberculosis uses the…”
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Tuberculostearic Acid Controls Mycobacterial Membrane Compartmentalization
Published in mBio (25-04-2023)“…The intracellular membrane domain (IMD) is a laterally discrete region of the mycobacterial plasma membrane, enriched in the subpolar region of the rod-shaped…”
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Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c
Published in Proceedings of the National Academy of Sciences - PNAS (25-02-2014)“…To identify lipids with roles in tuberculosis disease, we systematically compared the lipid content of virulent Mycobacterium tuberculosis with the attenuated…”
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Building Molecular Complexity from Quinizarin: Conjoined Coumarins and Coronene Analogs
Published in Chemistry, an Asian journal (15-05-2019)“…The double Knoevenagel condensation of 1,4‐dibenzoyloxyanthraquinone with methyl esters of arylacetic acids affords a series of compounds based upon a…”
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Asymmetric Total Synthesis of Mycobacterial Diacyl Trehaloses Demonstrates a Role for Lipid Structure in Immunogenicity
Published in ACS chemical biology (17-07-2020)“…The first asymmetric total synthesis of three structures proposed for mycobacterial diacyl trehaloses, DAT1, DAT2, and DAT3 is reported. The presence of two of…”
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Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system
Published in Proceedings of the National Academy of Sciences - PNAS (29-11-2011)“…Unlike the dominant role of one class II invariant chain peptide (CLIP) in blocking MHC class II, comparative lipidomics analysis shows that human cluster of…”
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Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle
Published in Scientific reports (21-01-2021)“…The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To overcome…”
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Determinants of Perinatal Mortality and Serious Neonatal Morbidity in the Second Twin
Published in Obstetrics and gynecology (New York. 1953) (01-09-2006)“…OBJECTIVE:To identify potential determinants of perinatal mortality and neonatal morbidity among second twins relative to first twins. METHODS:A retrospective…”
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Lipidomic analysis links mycobactin synthase K to iron uptake and virulence in M. tuberculosis
Published in PLoS pathogens (01-03-2015)“…The prolonged survival of Mycobacterium tuberculosis (M. tb) in the host fundamentally depends on scavenging essential nutrients from host sources. M. tb…”
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Lipidomic discovery of deoxysiderophores reveals a revised mycobactin biosynthesis pathway in Mycobacterium tuberculosis
Published in Proceedings of the National Academy of Sciences - PNAS (24-01-2012)“…To measure molecular changes underlying pathogen adaptation, we generated a searchable dataset of more than 12,000 mass spectrometry events, corresponding to…”
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In Vitro 24-Hour Time-Kill Studies of Vancomycin and Linezolid in Combination versus Methicillin-Resistant Staphylococcus aureus
Published in Antimicrobial Agents and Chemotherapy (01-10-2009)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Severe Maternal Morbidity in Canada, 2003 to 2007: Surveillance Using Routine Hospitalization Data and ICD-10CA Codes
Published in Journal of obstetrics and gynaecology Canada (01-09-2010)“…Abstract Objective To examine the feasibility of using routine labour and delivery hospitalization data and international classification of diseases (ICD-10CA)…”
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Ultralong C100 mycolic acids support the assignment of Segniliparus as a new bacterial genus
Published in PloS one (14-06-2012)“…Mycolic acid-producing bacteria isolated from the respiratory tract of human and non-human mammals were recently assigned as a distinct genus, Segniliparus,…”
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Mycobacterium tuberculosis SigM Positively Regulates Esx Secreted Protein and Nonribosomal Peptide Synthetase Genes and Down Regulates Virulence-Associated Surface Lipid Synthesis
Published in Journal of Bacteriology (01-12-2006)“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The pharmacokinetics and pharmacodynamics of continuous infusion vancomycin in adult people with cystic fibrosis
Published in Pediatric pulmonology (01-01-2024)“…Background The American Thoracic Society Guidelines recommend vancomycin as first line option for treatment of methicillin‐resistant Staphylococcus aureus. Two…”
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Temporal Trends and Regional Variations in Severe Maternal Morbidity in Canada, 2003 to 2007
Published in Journal of obstetrics and gynaecology Canada (01-09-2010)“…Abstract Objective To identify temporal trends and regional variations in severe maternal morbidity in Canada using routine hospitalization data. Methods We…”
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