Search Results - "Young, Charles Yf"

Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab by Wang, Dawei, Xu, Qingqing, Yuan, Quan, Jia, Mengqi, Niu, Huanmin, Liu, Xiaofei, Zhang, Jinsan, Young, Charles Yf, Yuan, Huiqing

“…Anterior gradient 2 (AGR2), a protein belonging to the protein disulfide isomerase (PDI) family, is overexpressed in multiple cancers and promotes angiogenesis…”
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miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells by Gong, Ai-Yu, Eischeid, Alex N, Xiao, Jing, Zhao, Jian, Chen, Dongqing, Wang, Zhao-Yi, Young, Charles Yf, Chen, Xian-Ming

“…Androgen receptor (AR) signalling is critical to the initiation and progression of prostate cancer (PCa). Transcriptional activity of AR involves chromatin…”
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Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells by FENGGE REN, SHAOBO ZHANG, MITCHELL, S. H, BUTLER, R, YOUNG, C. Y. F

“…Androgens via their cognate receptor may be involved in the development and progression of prostate cancer. The aim of this study was to determine whether tea…”
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Retigeric acid B-induced mitophagy by oxidative stress attenuates cell death against prostate cancer cells in vitro by Liu, Yong-qing, Ji, Yuan, Li, Xian-zhe, Tian, Ke-li, Yf Young, Charles, Lou, Hong-xiang, Yuan, Hui-qing

“…Aim： Retigeric acid B （RAB）, a pentacyclic triterpenic acid from Lobaria kurokawae Yoshim, has been found to induce apoptosis in prostate cancer cells. The aim…”
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Differential regulation of MMPs by E2F1, Sp1 and NF-kappa B controls the small cell lung cancer invasive phenotype by Li, Zunling, Guo, Yanxia, Jiang, Hanming, Zhang, Tingguo, Jin, Changzhu, Young, Charles Y F, Yuan, Huiqing

“…E2F1 transcription factor plays a vital role in the regulation of diverse cellular processes including cell proliferation, apoptosis, invasion and metastasis…”
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Jungermannenone A and B induce ROS- and cell cycle-dependent apoptosis in prostate cancer cells in vitro by Guo, Yan-xia, Lin, Zhao-min, Wang, Mei-juan, Dong, Yi-wen, Niu, Huan-min, Young, Charles YF, Lou, Hong-xiang, Yuan, Hui-qing

“…Aim, Jungermannenone A and B （JA, JB） are new ent-kaurane diterpenoids isolated from Chinese liverwort Jungermannia fauriana, which show anti-proliferation…”
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Sesquiterpenoids from myrrh inhibit androgen receptor expression and function in human prostate cancer cells by Wang, Xiao-ling, Kong, Feng, Shen, Tao, Young, Charles YF, Lou, Hong-xiang, Yuan, Hui-qing

“…Aim： To examine whether two naturally occurring sesquiterpenoids （ST1 and ST2） with anti-proliferative activity in prostate cancer cells inhibit androgen…”
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Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells by Xi, Guangmin, Hu, Xiaoyan, Wu, Baolin, Jiang, Hanming, Young, Charles Y.F, Pang, Yingxin, Yuan, Huiqing

“…Abstract Paclitaxel has been demonstrated to be an effective mitotic inhibitor and apoptosis inducer to treat aggressive malignancies. In this paper, we have…”
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Curcumin downregulates homeobox gene NKX3.1 in prostate cancer cell LNCaP by Zhang, Hui-Na, Yu, Chun-Xiao, Zhang, Peng-Ju, Chen, Wei-Wen, Jiang, An-Li, Kong, Feng, Deng, Jing-Ti, Zhang, Jian-Ye, Young, Charles Yf

“…Aim： To elucidate the effect and the mechanisms of curcumin on the expression of the human homeobox gene NKX3.1 in the prostate cancer cell LNCaP. Methods： The…”
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Global Methylation Profiling for Risk Prediction of Prostate Cancer by MAHAPATRA, Saswati, KLEE, Eric W, YOUNG, Charles Y. F, ZHIFU SUN, JIMENEZ, Rafael E, KLEE, George G, TINDALL, Donald J, VANAJA DONKENA, Krishna

“…The aim of this study was to investigate the promoter hypermethylation as diagnostic markers to detect malignant prostate cells and as prognostic markers to…”
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Anterior gradient 2 increases long-chain fatty acid uptake via stabilizing FABP1 and facilitates lipid accumulation by Wang, Yunqiu, Jia, Mengqi, Liang, Chuanjie, Sheng, Nan, Wang, Xiaodan, Wang, Fang, Luo, Yanhai, Jiang, Jin, Cai, Liangyu, Niu, Huanmin, Zhu, Deyu, Nesa, Effat Un, Young, Charles Yf, Yuan, Huiqing

“…Anterior gradient 2 (AGR2), a protein disulfide isomerase (PDI), is a well-established oncogene. Here, we found that mice had a decreased fat mass and hepatic…”
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Phenethyl isothiocyanate inhibits androgen receptor-regulated transcriptional activity in prostate cancer cells through suppressing PCAF by Yu, Chunguang, Gong, Ai-Yu, Chen, Dongqing, Solelo Leon, Daniel, Young, Charles YF, Chen, Xian-Ming

“…Scope Androgen receptor (AR) signaling is critical for all aspects of prostate growth and tumorigenesis. The glucosinolate‐derived phenethyl isothiocyanate…”
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Induction of DNA damage and ATF3 by retigeric acid B, a novel topoisomerase II inhibitor, promotes apoptosis in prostate cancer cells by Liu, Yongqing, Gao, Fengbin, Jiang, Hanming, Niu, Leilei, Bi, Yiling, Young, Charles Y.F, Yuan, Huiqing, Lou, Hongxiang

“…Highlights • Retigeric acid B inhibits activity of topoisomerase IIα. • Retigeric acid B triggers cell death by inducing DNA damage and locking DNA damage…”
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PDLIM4 repression by hypermethylation as a potential biomarker for prostate cancer by DONKENA KRISHNA VANAJA, BALLMAN, Karla V, MORLAN, Bruce W, CHEVILLE, John C, NEUMANN, Roxann M, LIEBER, Michael M, TINDALL, Donald J, YOUNG, Charles Y. F

“…PURPOSE: We analyzed the expression of genes to identify reliable molecular markers in the diagnosis and progression of prostate cancer. EXPERIMENTAL DESIGN:…”
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A novel anticancer agent, retigeric acid B, displays proliferation inhibition, S phase arrest and apoptosis activation in human prostate cancer cells by Liu, Han, Liu, Yi-qing, Liu, Yong-qing, Xu, Ai-hui, Young, Charles Y.F., Yuan, Hui-qing, Lou, Hong-xiang

“…Retigeric acid B (RB), a naturally occurring pentacyclic triterpenic acid, has been noted for its antifungal properties in vitro. Here, we observed that RB…”
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Abstract 4950: Correlation of methylation status with expression levels of the genes in prostate cancer by Klee, Eric W., Blute, Michael L., Young, Charles YF, Tindall, Donald J., Klee, George G., Donkena, Krishna Vanaja

“…Abstract DNA methylation abnormalities, either gain or loss of methylation in promoters or other regulatory regions, contribute to tumorigenesis by altering…”
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Perillyl alcohol inhibits the expression and function of the androgen receptor in human prostate cancer cells by Chung, Byung Ha, Lee, Hye-young, Lee, Jae Seok, Young, Charles Y.F.

“…Perillyl alcohol is a hydroxylated monocyclic monoterpene. In animal study, monoterpene has shown to have an anti-tumor effect. The aim of this study is to…”
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Whole blood defensin mRNA expression is a predictive biomarker of docetaxel response in castration-resistant prostate cancer by Kohli, Manish, Young, Charles Yf, Tindall, Donald J, Nandy, Debashis, McKenzie, Kyle M, Bevan, Graham H, Donkena, Krishna Vanaja

“…This study tested the potential of circulating RNA-based signals as predictive biomarkers for docetaxel response in patients with metastatic…”
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Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells by Yuan, Huiqing, Pan, Yunqian, Young, Charles Y.F.

“…Previously, we reported that quercetin and resveratrol inhibit the function of androgen receptor (AR). Further studies showed that these two polyphenols caused…”
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Vitamins and prostate cancer risk by Donkena, Krishna Vanaja, Karnes, R Jeffrey, Young, Charles Y F

“…Prostate cancer (PC) is the second most common cancer in men worldwide. Its prevention and treatment remain a challenge to clinicians. Here we review the…”
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