Search Results - "Young, Charles Y.F"

Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells by Xi, Guangmin, Hu, Xiaoyan, Wu, Baolin, Jiang, Hanming, Young, Charles Y.F, Pang, Yingxin, Yuan, Huiqing

“…Abstract Paclitaxel has been demonstrated to be an effective mitotic inhibitor and apoptosis inducer to treat aggressive malignancies. In this paper, we have…”
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Induction of DNA damage and ATF3 by retigeric acid B, a novel topoisomerase II inhibitor, promotes apoptosis in prostate cancer cells by Liu, Yongqing, Gao, Fengbin, Jiang, Hanming, Niu, Leilei, Bi, Yiling, Young, Charles Y.F, Yuan, Huiqing, Lou, Hongxiang

“…Highlights • Retigeric acid B inhibits activity of topoisomerase IIα. • Retigeric acid B triggers cell death by inducing DNA damage and locking DNA damage…”
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Involvement of transcription factor Sp1 in quercetin-mediated inhibitory effect on the androgen receptor in human prostate cancer cells by Yuan, Huiqing, Gong, Aiyu, Young, Charles Y.F.

“…The transactivation function of the human androgen receptor (AR) can be regulated by several coregulators that may be either positive or negative. Ubiquitous…”
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Global Methylation Profiling for Risk Prediction of Prostate Cancer by MAHAPATRA, Saswati, KLEE, Eric W, YOUNG, Charles Y. F, ZHIFU SUN, JIMENEZ, Rafael E, KLEE, George G, TINDALL, Donald J, VANAJA DONKENA, Krishna

“…The aim of this study was to investigate the promoter hypermethylation as diagnostic markers to detect malignant prostate cells and as prognostic markers to…”
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miR-141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein by Xiao, Jing, Gong, Ai-Yu, Eischeid, Alex N., Chen, Dongqing, Deng, Caishu, Young, Charles Y.F., Chen, Xian-Ming

“…BACKGROUND Aberrant expressions of microRNAs, including upregulation of miR‐141, are closely associated with the tumorigenesis of prostate cancer (PCa). The…”
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Hypermethylation of Genes for Diagnosis and Risk Stratification of Prostate Cancer by Vanaja, Donkena Krishna, Ehrich, Mathias, Van den Boom, Dirk, Cheville, John C., Karnes, R. Jeffrey, Tindall, Donald J., Cantor, Charles R., Young, Charles Y.F.

“…To identify the relevant CpG sites as molecular markers, for the diagnosis and to distinguish the indolent and aggressive prostate tumors, we have determined…”
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Phenethyl isothiocyanate inhibits STAT3 activation in prostate cancer cells by Gong, Aiyu, He, Meilan, Krishna Vanaja, Donkena, Yin, Ping, Karnes, R. Jeffrey, Young, Charles Y.F

“…This study was undertaken to investigate the mechanism by which phenethyl isothiocyanate (PEITC), a natural compound from cruciferous vegetables, exhibits…”
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Perillyl alcohol inhibits the expression and function of the androgen receptor in human prostate cancer cells by Chung, Byung Ha, Lee, Hye-young, Lee, Jae Seok, Young, Charles Y.F.

“…Perillyl alcohol is a hydroxylated monocyclic monoterpene. In animal study, monoterpene has shown to have an anti-tumor effect. The aim of this study is to…”
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Whole blood defensin mRNA expression is a predictive biomarker of docetaxel response in castration-resistant prostate cancer by Kohli, Manish, Young, Charles Yf, Tindall, Donald J, Nandy, Debashis, McKenzie, Kyle M, Bevan, Graham H, Donkena, Krishna Vanaja

“…This study tested the potential of circulating RNA-based signals as predictive biomarkers for docetaxel response in patients with metastatic…”
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Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells by Yuan, Huiqing, Pan, Yunqian, Young, Charles Y.F.

“…Previously, we reported that quercetin and resveratrol inhibit the function of androgen receptor (AR). Further studies showed that these two polyphenols caused…”
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Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP by Zhu, Wen, Zhang, Jin-San, Young, Charles Y.F.

“…A number of reports have shown that the polyphenolic flavonoid silymarin (SM) is an effective anticancer agent. Agents with novel mechanisms of blocking…”
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Methyl selenium metabolites decrease prostate-specific antigen expression by inducing protein degradation and suppressing androgen-stimulated transcription by Cho, Sung Dae, Jiang, Cheng, Malewicz, Barbara, Dong, Yan, Young, Charles Y F, Kang, Kyung-Sun, Lee, Yong-Soon, Ip, Clement, Lü, Junxuan

“…Prostate-specific antigen (PSA) is widely used clinically for prostate cancer diagnostics and as an indicator of therapeutic efficacy and recurrence. Several…”
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Vitamins and prostate cancer risk by Donkena, Krishna Vanaja, Karnes, R Jeffrey, Young, Charles Y F

“…Prostate cancer (PC) is the second most common cancer in men worldwide. Its prevention and treatment remain a challenge to clinicians. Here we review the…”
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Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer by Gazi, Mozammel H., He, MeiLan, Cheville, John C., Young, Charles Y.F.

“…By means of protein expression profile, mass spectral and/or RT-PCR analyses we found for the first time IgG Fc binding protein (FcγBP), distinct from Fcγ…”
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Proteomics shows Hsp70 does not bind peptide sequences indiscriminately in vivo by Grossmann, Michael E, Madden, Benjamin J, Gao, Fan, Pang, Yuan-Ping, Carpenter, John E, McCormick, Daniel, Young, Charles Y.F

“…Heat shock protein 70 (Hsp70) binds peptide and has several functions that include protein folding, protein trafficking, and involvement with immune function…”
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Human glandular kallikrein 2 expression in prostate adenocarcinoma and lymph node metastases by Darson, Micheal F, Pacelli, Anna, Roche, Patrick, Rittenhouse, Harry G, Wolfert, Robert L, Saeid, Mohammad S, Young, Charles Y.F, Klee, George G, Tindall, Donald J, Bostwick, David G

“…Objectives. To describe the expression of a potential new tumor marker, human glandular kallikrein 2 (hK2), in primary adenocarcinoma and lymph node metastases…”
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MicroRNAs and prostate cancer by Pang, Yingxin, Young, Charles Y F, Yuan, Huiqing

“…MicroRNAs (miRNAs) are a class of small, non-coding, single-stranded RNAs that negatively regulate gene expression by mainly binding to 30 untranslated region…”
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The effects of dietary factors on the androgen receptor and related cellular factors in prostate cancer by Young, Charles Y F, Jatoi, Aminah, Ward, John F, Blute, Michael L

“…It has been strongly suggested that androgens and the cognate receptor (AR) may play important roles in the development and progression of prostate cancer. The…”
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Highly Sensitive Automated Chemiluminometric Assay for Measuring Free Human Glandular Kallikrein-2 by Klee, George G, Goodmanson, Marcia K, Jacobsen, Steven J, Young, Charles Y.F, Finlay, Judith A, Rittenhouse, Harry G, Wolfert, Robert L, Tindall, Donald J

“…Human glandular kallikrein (hK2) is a serine protease that has 79% amino acid identity with prostate-specific antigen (PSA). Both free hK2 and hK2 complexed to…”
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Pro-metastatic activity of AGR2 interrupts angiogenesis target bevacizumab efficiency via direct interaction with VEGFA and activation of NF-κB pathway by Jia, Mengqi, Guo, Yanxia, Zhu, Deyu, Zhang, Nianzhao, Li, Lin, Jiang, Jin, Dong, Yiwen, Xu, Qingqing, Zhang, Xiulei, Wang, Meijuan, Yu, Haina, Wang, Fang, Tian, Keli, Zhang, Jinsan, Young, Charles Y.F., Lou, Hongxiang, Yuan, Huiqing

“…Anterior gradient 2 (AGR2), an endoplasmic reticulum (ER)-resident protein-disulfide isomerase (PDI), is associated with cancer development and malignant…”
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