Search Results - "Young, Charles W."

Near-island biological hotspots in barren ocean basins by Gove, Jamison M., McManus, Margaret A., Neuheimer, Anna B., Polovina, Jeffrey J., Drazen, Jeffrey C., Smith, Craig R., Merrifield, Mark A., Friedlander, Alan M., Ehses, Julia S., Young, Charles W., Dillon, Amanda K., Williams, Gareth J.

“…Phytoplankton production drives marine ecosystem trophic-structure and global fisheries yields. Phytoplankton biomass is particularly influential near coral…”
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Baseline Assessment of Net Calcium Carbonate Accretion Rates on U.S. Pacific Reefs by Vargas-Ángel, Bernardo, Richards, Cristi L, Vroom, Peter S, Price, Nichole N, Schils, Tom, Young, Charles W, Smith, Jennifer, Johnson, Maggie D, Brainard, Russell E

“…This paper presents a comprehensive quantitative baseline assessment of in situ net calcium carbonate accretion rates (g CaCO3 cm(-2) yr(-1)) of early…”
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Repeat bleaching of a central Pacific coral reef over the past six decades (1960–2016) by Barkley, Hannah C., Cohen, Anne L., Mollica, Nathaniel R., Brainard, Russell E., Rivera, Hanny E., DeCarlo, Thomas M., Lohmann, George P., Drenkard, Elizabeth J., Alpert, Alice E., Young, Charles W., Vargas-Ángel, Bernardo, Lino, Kevin C., Oliver, Thomas A., Pietro, Kathryn R., Luu, Victoria H.

“…The oceans are warming and coral reefs are bleaching with increased frequency and severity, fueling concerns for their survival through this century. Yet in…”
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Impact of storm runoff from tropical watersheds on coastal water quality and productivity by De Carlo, E. Heinen, Hoover, Daniel J., Young, Charles W., Hoover, Rebecca S., Mackenzie, Fred T.

“…Storm runoff in the steep watersheds in Hawaii leads to sediment and freshwater pulses to coastal waters that quickly affect nearshore water quality. This is…”
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Comparison of equatorial Pacific sea surface temperature variability and trends with Sr/Ca records from multiple corals by Alpert, Alice E., Cohen, Anne L., Oppo, Delia W., DeCarlo, Thomas M., Gove, Jamison M., Young, Charles W.

“…Coral Sr/Ca is widely used to reconstruct past ocean temperatures. However, some studies report different Sr/Ca‐temperature relationships for conspecifics on…”
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Skeletal records of bleaching reveal different thermal thresholds of Pacific coral reef assemblages by Mollica, Nathaniel R., Cohen, Anne L., Alpert, Alice E., Barkley, Hannah C., Brainard, Russell E., Carilli, Jessica E., DeCarlo, Thomas M., Drenkard, Elizabeth J., Lohmann, Pat, Mangubhai, Sangeeta, Pietro, Kathryn R., Rivera, Hanny E., Rotjan, Randi D., Scott-Buechler, Celina, Solow, Andrew R., Young, Charles W.

“…Ocean warming is negatively impacting coral reef ecosystems and considerable effort is currently invested in projecting coral reef futures under 21st century…”
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Coral reef carbonate accretion rates track stable gradients in seawater carbonate chemistry across the U.S. Pacific Islands by Barkley, Hannah C., Oliver, Thomas A., Halperin, Ariel A., Pomeroy, Noah V., Smith, Joy N., Weible, Rebecca M., Young, Charles W., Couch, Courtney S., Brainard, Russell E., Samson, Jennifer C.

“…The U.S. Pacific Islands span a dramatic natural gradient in climate and oceanographic conditions, and benthic community states vary significantly across the…”
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Correction to: Skeletal records of bleaching reveal different thermal thresholds of Pacific coral reef assemblages by Mollica, Nathaniel R., Cohen, Anne L., Alpert, Alice E., Barkley, Hannah C., Brainard, Russell E., Carilli, Jessica E., DeCarlo, Thomas M., Drenkard, Elizabeth J., Lohmann, Pat, Mangubhai, Sangeeta, Pietro, Kathryn R., Rivera, Hanny E., Rotjan, Randi D., Scott-Buechler, Celina, Solow, Andrew R., Young, Charles W.

“…Figure 2 in the original article has been updated with this figure 2 due to discrepancies related to incorrect mapping with one of the islands…”
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Phase I dose escalation clinical trial of phenylbutyrate sodium administered twice daily to patients with advanced solid tumors by Camacho, Luis H, Olson, Jon, Tong, William P, Young, Charles W, Spriggs, David R, Malkin, Mark G

“…Phenylbutyrate (PBA), and its metabolite phenylacetate (PAA), induce growth inhibition and cellular differentiation in multiple tumor models. However, despite…”
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Clinical pharmacology of oral all-trans retinoic acid in patients with acute promyelocytic leukemia by MUINDI, J. R. F, FRANKEL, S. R, HUSELTON, C, DEGRAZIA, F, GARLAND, W. A, YOUNG, C. W, WARRELL, R. P

“…All-trans retinoic acid (RA) induces leukemic cell differentiation and complete remission in a high proportion of patients with acute promyelocytic leukemia…”
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A clinical trial of amygdalin (Laetrile) in the treatment of human cancer by Moertel, C G, Fleming, T R, Rubin, J, Kvols, L K, Sarna, G, Koch, R, Currie, V E, Young, C W, Jones, S E, Davignon, J P

“…One hundred seventy-eight patients with cancer were treated with amygdalin (Laetrile) plus a "metabolic therapy" program consisting of diet, enzymes, and…”
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Comparison of methods of evaluating nephrotoxicity of cis-platinum by Jones, B R, Bhalla, R B, Mladek, J, Kaleya, R N, Gralla, R J, Alcock, N W, Schwartz, M K, Young, C W, Reidenberg, M M

“…The urinary excretion of leucine aminopeptidase (LAP), N-acetyl-beta-glucosaminidase (NAG), and beta 2-microglobulin was measured in 12 cancer patients…”
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Lipid hydroperoxides greatly increase the rate of oxidative catabolism of all-trans-retinoic acid by human cell culture microsomes genetically enriched in specified cytochrome P-450 isoforms by MUINDI, J. F, YOUNG, C. W

“…Cytochrome P-450 enzymes have been implicated in the oxidative catabolism of all-trans-retinoic acid (RA), a process that is accelerated by exposure to RA in…”
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Hydroxyurea: Inhibitory Effect on DNA Metabolism by Young, Charles W., Hodas, Sadie

“…Hydroxyurea, hydroxyurethane, and dihydroxyurea inhibit incorporation of thymidine into the DNA of monolayers of HeLa cells. They do not affect incorporation…”
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Antiemetic efficacy of high-dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting by Gralla, R J, Itri, L M, Pisko, S E, Squillante, A E, Kelsen, D P, Braun, Jr, D W, Bordin, L A, Braun, T J, Young, C W

“…In a study of the effectiveness of high intravenous doses of metoclopramide as an antiemetic, 41 patients with advanced cancer who were being treated with…”
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Potentiation of radiation effects on two murine tumors by lonidamine by JAE HO KIM, ALFIERI, A. A, SANG HIE KIM, YOUNG, C. W

“…Lonidamine is a potent inhibitor of spermatogenesis and a hyperthermic sensitizer. The principal established locus of biochemical action of lonidamine is a…”
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Phase I trial and clinical pharmacological evaluation of 10-ethyl-10-deazaaminopterin in adult patients with advanced cancer by KRIS, M. G, KINAHAN, J. J, SIROTNAK, F. M, GRALLA, R. J, FANUCCHI, M. P, WERTHEIM, M. S, O'CONNELL, J. P, MARKS, L. D, WILLIAMS, L, FARAG, F, YOUNG, C. W

“…10-Ethyl-10-deazaaminopterin (10-EDAM) is an analogue of methotrexate with improved preclinical anticancer activity, more selective entry, and greater…”
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Phase I and II clinical and pharmacological study of 4-demethoxydaunorubicin (idarubicin) in adult patients with acute leukemia by DAGHESTANI, A. N, ARLIN, Z. A, CLARKSON, B. D, YOUNG, C. W, LEYLAND-JONES, B, GEE, T. S, KEMPIN, S. J, MERTELSMANN, R, BUDMAN, D, SCHULMAN, P, BARATZ, R, WILLIAMS, L

“…Fifty-two adults treated previously with either acute leukemia (43 patients) or blastic-phase chronic myelogenous leukemia (nine patients) received…”
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Quercetin, an inhibitor of lactate transport and a hyperthermic sensitizer of HeLa cells by JAE HO KIM, SANG HIE KIM, ALFIERI, A. A, YOUNG, C. W

“…Since cancer cells produce large amounts of lactate via aerobic glycolysis and since an acidic pH has been shown to selectively enhance the cytotoxic effects…”
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High-dose 5-fluorouracil with delayed uridine "rescue" in mice by Martin, D S, Stolfi, R L, Sawyer, R C, Spiegelman, S, Young, C W

“…Because of the association between the incorporation of 5-fluorouracil (FUra) into RNA and cytotoxicity, uridine was examined for potential selective reduction…”
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