Search Results - "Young, Bryan D."

Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis by Damsky, William, Wang, Alice, Kim, Daniel J., Young, Bryan D., Singh, Katelyn, Murphy, Michael J., Daccache, Joseph, Clark, Abigale, Ayasun, Ruveyda, Ryu, Changwan, McGeary, Meaghan K., Odell, Ian D., Fazzone-Chettiar, Ramesh, Pucar, Darko, Homer, Robert, Gulati, Mridu, Miller, Edward J., Bosenberg, Marcus, Flavell, Richard A., King, Brett

“…Sarcoidosis is an idiopathic inflammatory disorder that is commonly treated with glucocorticoids. An imprecise understanding of the immunologic changes…”
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Histone Deacetylase 7 Maintains Vascular Integrity by Repressing Matrix Metalloproteinase 10 by Chang, Shurong, Young, Bryan D., Li, Shijie, Qi, Xiaoxia, Richardson, James A., Olson, Eric N.

“…Development and homeostasis of the cardiovascular system require intimate interactions between endothelial and smooth muscle cells, which form a seamless…”
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Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia by Paulsson, Kajsa, Forestier, Erik, Lilljebjörn, Henrik, Heldrup, Jesper, Behrendtz, Mikael, Young, Bryan D., Johansson, Bertil, Rowley, Janet D.

“…High hyperdiploid acute lymphoblastic leukemia (ALL) is one of the most common malignancies in children. It is characterized by gain of chromosomes, typically…”
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Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia by Dixon-McIver, Amanda, East, Phil, Mein, Charles A, Cazier, Jean-Baptiste, Molloy, Gael, Chaplin, Tracy, Andrew Lister, T, Young, Bryan D, Debernardi, Silvana

“…Acute myeloid leukaemia (AML) is the most common acute leukaemia in adults; however, the genetic aetiology of the disease is not yet fully understood. A…”
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Repeatability and Optimization of FDG Positron Emission Tomography for Evaluation of Cardiac Sarcoidosis by Alvi, Raza M., Young, Bryan D., Shahab, Zartashia, Pan, Hongyi, Winkler, Julia, Herzog, Erica, Miller, Edward J.

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Treatment of Multiorgan Sarcoidosis With Tofacitinib by Damsky, William, Young, Bryan D., Sloan, Brett, Miller, Edward J., Obando, J. Antonio, King, Brett

“…Objective Sarcoidosis is an idiopathic inflammatory disorder that is difficult to treat. There is accumulating evidence that constitutive activation of Janus…”
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Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas by Forshew, Tim, Tatevossian, Ruth G, Lawson, Andrew RJ, Ma, Jing, Neale, Geoff, Ogunkolade, Babatunji W, Jones, Tania A, Aarum, Johan, Dalton, James, Bailey, Simon, Chaplin, Tracy, Carter, Rowena L, Gajjar, Amar, Broniscer, Alberto, Young, Bryan D, Ellison, David W, Sheer, Denise

“…We report genetic aberrations that activate the ERK/MAP kinase pathway in 100% of posterior fossa pilocytic astrocytomas, with a high frequency of gene fusions…”
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Distinct Genomic Alterations in Prostate Cancers in Chinese and Western Populations Suggest Alternative Pathways of Prostate Carcinogenesis by XUEYING MAO, YONGWEI YU, GUPTA, Manu, OLIVER, R. Tim D, LEMOINE, Nick R, BERNEY, Daniel M, YOUNG, Bryan D, LU, Yong-Jie, BOYD, Lara K, GUOPING REN, DONGMEI LIN, CHAPLIN, Tracy, KUDAHETTI, Sakunthala C, STANKIEWICZ, Elzbieta, LIYAN XUE, BELTRAN, Luis

“…Prostate cancer is significantly more common in Western men than in Asian men, but the basis for this difference remains unknown. Because genomic studies of…”
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Cytokine Signaling and Matrix Remodeling Pathways Associated with Cardiac Sarcoidosis Disease Activity Defined Using FDG PET Imaging by Young, Bryan D., Moreland, Hannah, Oatmen, Kelsie E., Freeburg, Lisa A., Shahab, Zartashia, Herzog, Erica, Miller, Edward J., Spinale, Francis G.

“…While cardiac imaging has improved the diagnosis and risk assessment for cardiac sarcoidosis (CS), treatment regimens have consisted of generalized heart…”
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FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation by Gemenetzidis, Emilios, Bose, Amrita, Riaz, Adeel M, Chaplin, Tracy, Young, Bryan D, Ali, Muhammad, Sugden, David, Thurlow, Johanna K, Cheong, Sok-Ching, Teo, Soo-Hwang, Wan, Hong, Waseem, Ahmad, Parkinson, Eric K, Fortune, Farida, Teh, Muy-Teck

“…Cancer associated with smoking and drinking remains a serious health problem worldwide. The survival of patients is very poor due to the lack of effective…”
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Histone deacetylase 7 regulates cell survival and TCR signaling in CD4/CD8 double-positive thymocytes by Kasler, Herbert G, Young, Bryan D, Mottet, Denis, Lim, Hyung W, Collins, Amy M, Olson, Eric N, Verdin, Eric

“…CD4/CD8 double-positive thymocytes express the transcriptional repressor histone deacetylase (HDAC)7, a class IIa HDAC that is exported from the cell nucleus…”
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Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia by Kearney, Lyndal, Gonzalez De Castro, David, Yeung, Jenny, Procter, Julia, Horsley, Sharon W., Eguchi-Ishimae, Minenori, Bateman, Caroline M., Anderson, Kristina, Chaplin, Tracy, Young, Bryan D., Harrison, Christine J., Kempski, Helena, Wai E. So, Chi, Ford, Anthony M., Greaves, Mel

“…Children with Down syndrome (DS) have a greatly increased risk of acute megakaryoblastic leukemia (AMKL) and acute lymphoblastic leukemia (ALL). Both DS-AMKL…”
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ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial by Rose-Zerilli, Matthew J J, Forster, Jade, Parker, Helen, Parker, Anton, Rodríguez, Ana E, Chaplin, Tracy, Gardiner, Anne, Steele, Andrew J, Collins, Andrew, Young, Bryan D, Skowronska, Anna, Catovsky, Daniel, Stankovic, Tatjana, Oscier, David G, Strefford, Jonathan C

“…ATM mutation and BIRC3 deletion and/or mutation have independently been shown to have prognostic significance in chronic lymphocytic leukemia. However, the…”
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Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis by Morrison, Alan R, Yarovinsky, Timur O, Young, Bryan D, Moraes, Filipa, Ross, Tyler D, Ceneri, Nicolle, Zhang, Jiasheng, Zhuang, Zhen W, Sinusas, Albert J, Pardi, Ruggero, Schwartz, Martin A, Simons, Michael, Bender, Jeffrey R

“…Myeloid cells are important contributors to arteriogenesis, but their key molecular triggers and cellular effectors are largely unknown. We report, in…”
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Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats by Saied, Marwa H, Marzec, Jacek, Khalid, Sabah, Smith, Paul, Down, Thomas A, Rakyan, Vardhman K, Molloy, Gael, Raghavan, Manoj, Debernardi, Silvana, Young, Bryan D

“…Methylated DNA immunoprecipitation followed by high-throughput sequencing (MeDIP-seq) has the potential to identify changes in DNA methylation important in…”
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Non-steroidal treatment of cardiac sarcoidosis: A systematic review by Gallegos, Cesia, Oikonomou, Evangelos K., Grimshaw, Alyssa, Gulati, Mridu, Young, Bryan D., Miller, Edward J.

“…The treatment of active cardiac sarcoidosis (CS) usually involves immunosuppressive therapy, with the goal of preventing inflammation-induced scar formation…”
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Genome-wide single nucleotide polymorphism analysis reveals frequent partial uniparental disomy due to somatic recombination in acute myeloid leukemias by RAGHAVAN, Manoj, LILLINGTON, Debra M, SKOULAKIS, Spyros, DEBERNARDI, Silvana, CHAPLIN, Tracy, FOOT, Nicola J, LISTER, T. Andrew, YOUNG, Bryan D

“…Genome-wide analysis of single nucleotide polymorphisms in 64 acute myeloid leukemias has revealed that approximately 20% exhibited large regions of…”
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AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML by Pearce, Daniel J., Taussig, David, Zibara, Kazem, Smith, Lan-Lan, Ridler, Christopher M., Preudhomme, Claude, Young, Bryan D., Rohatiner, Ama Z., Lister, T. Andrew, Bonnet, Dominique

“…The nonobese diabetic/severe combined immunodeficient (NOD/SCID) assay is the current model for assessment of human normal and leukemic stem cells. We explored…”
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Relative predictive value of lung cancer screening CT versus myocardial perfusion attenuation correction CT in the evaluation of coronary calcium by Bailey, Grant, Healy, Abigail, Young, Bryan D, Sharma, Esseim, Meadows, Judith, Chun, Hyung J, Wu, Wen-Chih, Choudhary, Gaurav, Morrison, Alan R

“…Coronary artery calcium scores (CACS) from lung cancer screening computed tomography (LCSCT) or myocardial perfusion attenuation correction computed tomography…”
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Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes by Teh, Muy-Teck, Gemenetzidis, Emilios, Chaplin, Tracy, Young, Bryan D, Philpott, Michael P

“…The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation…”
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