Search Results - "Young, A. T."

HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2 by Ocwieja, Karen E, Brady, Troy L, Ronen, Keshet, Huegel, Alyssa, Roth, Shoshannah L, Schaller, Torsten, James, Leo C, Towers, Greg J, Young, John A T, Chanda, Sumit K, König, Renate, Malani, Nirav, Berry, Charles C, Bushman, Frederic D

“…Genome-wide siRNA screens have identified host cell factors important for efficient HIV infection, among which are nuclear pore proteins such as RanBP2/Nup358…”
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Correlation-Driven Insulator-Metal Transition in Near-Ideal Vanadium Dioxide Films by Gray, A X, Jeong, J, Aetukuri, N P, Granitzka, P, Chen, Z, Kukreja, R, Higley, D, Chase, T, Reid, A H, Ohldag, H, Marcus, M A, Scholl, A, Young, A T, Doran, A, Jenkins, C A, Shafer, P, Arenholz, E, Samant, M G, Parkin, S S P, Dürr, H A

“…We use polarization- and temperature-dependent x-ray absorption spectroscopy, in combination with photoelectron microscopy, x-ray diffraction, and electronic…”
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Host cell factors in HIV replication: meta-analysis of genome-wide studies by Bushman, Frederic D, Malani, Nirav, Fernandes, Jason, D'Orso, Iván, Cagney, Gerard, Diamond, Tracy L, Zhou, Honglin, Hazuda, Daria J, Espeseth, Amy S, König, Renate, Bandyopadhyay, Sourav, Ideker, Trey, Goff, Stephen P, Krogan, Nevan J, Frankel, Alan D, Young, John A T, Chanda, Sumit K

“…We have analyzed host cell genes linked to HIV replication that were identified in nine genome-wide studies, including three independent siRNA screens…”
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Correlation between exchange bias and pinned interfacial spins by Ohldag, H, Scholl, A, Nolting, F, Arenholz, E, Maat, S, Young, A T, Carey, M, Stöhr, J

“…Using x-ray magnetic circular dichroism, we have detected the very interfacial spins that are responsible for the horizontal loop shift in three different…”
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QLU-C10D: a health state classification system for a multi-attribute utility measure based on the EORTC QLQ-C30 by King, M. T., Costa, D. S. J., Aaronson, N. K., Brazier, J. E., Cella, D. F., Fayers, P. M., Grimison, P., Janda, M., Kemmler, G., Norman, R., Pickard, A. S., Rowen, D., Velikova, G., Young, T. A., Viney, R.

“…Purpose To derive a health state classification system (HSCS) from the cancer-specific quality of life questionnaire, the EORTC QLQ-C30, as the basis for a…”
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Electrical switching of the magnetic vortex circulation in artificial multiferroic structure of Co/Cu/PMN-PT(011) by Li, Q., Tan, A., Scholl, A., Young, A. T., Yang, M., Hwang, C., N'Diaye, A. T., Arenholz, E., Li, J., Qiu, Z. Q.

“…Co films and micron sized disks were grown on top of piezoelectric PMN-PT(011) and Cu/PMN-PT(001) substrates and investigated by the Magneto-Optic Kerr Effect…”
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Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes by Zeng, Jing, Wu, Daitze, Hu, Hui, Young, John A.T., Yan, Zhipeng, Gao, Lu

“…Background and Aims Hepatitis B virus (HBV) infection is ranked among the top health priorities worldwide. Accumulating evidence suggests that HBV infection…”
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Identification of the cellular receptor for anthrax toxin by Young, John A. T, Bradley, Kenneth A, Mogridge, Jeremy, Mourez, Michael, Collier, R. John

“…The tripartite toxin secreted by Bacillus anthracis, the causative agent of anthrax, helps the bacterium evade the immune system and can kill the host during a…”
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Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity by Reeves, Claire V, Wang, Xing, Charles-Horvath, Pelisa C, Vink, Joy Y, Borisenko, Valeriya Y, Young, John A T, Kitajewski, Jan K

“…Anthrax Toxin Receptor proteins function as receptors for anthrax toxin, however physiological activity remains unclear. To evaluate the biological role of…”
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PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization by Mueller, Henrik, Lopez, Anaïs, Tropberger, Philipp, Wildum, Steffen, Schmaler, Josephine, Pedersen, Lykke, Han, Xingchun, Wang, Yongguang, Ottosen, Søren, Yang, Song, Young, John A.T., Javanbakht, Hassan

“…RG7834 is a potent, orally bioavailable small‐molecule inhibitor of hepatitis B virus (HBV) gene expression that belongs to the dihydroquinolizinone (DHQ)…”
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Anthrax toxin receptor 2 is expressed in murine and tumor vasculature and functions in endothelial proliferation and morphogenesis by Reeves, C V, Dufraine, J, Young, J A T, Kitajewski, J

“…The C apillary M orphogenesis G ene 2 (CMG2) gene encodes an Anthrax toxin receptor (ANTXR2), but the normal physiological function is not known. ANTXR2/CMG2…”
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Discovery of Small Molecule Therapeutics for Treatment of Chronic HBV Infection by Feng, Song, Gao, Lu, Han, Xingchun, Hu, Taishan, Hu, Yimin, Liu, Haixia, Thomas, Andrew W, Yan, Zhipeng, Yang, Song, Young, John A. T, Yun, Hongying, Zhu, Wei, Shen, Hong C

“…The chronic infection of hepatitis B virus (HBV) inflicts 250 million people worldwide representing a major public health threat. A significant subpopulation…”
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Imaging single retrovirus entry through alternative receptor isoforms and intermediates of virus-endosome fusion by Jha, Naveen K, Latinovic, Olga, Martin, Erik, Novitskiy, Gennadiy, Marin, Mariana, Miyauchi, Kosuke, Naughton, John, Young, John A T, Melikyan, Gregory B

“…A large group of viruses rely on low pH to activate their fusion proteins that merge the viral envelope with an endosomal membrane, releasing the viral…”
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Direct Inhibition of Hepatitis B e Antigen by Core Protein Allosteric Modulator by Yan, Zhipeng, Wu, Daitze, Hu, Hui, Zeng, Jing, Yu, Xin, Xu, Zhiheng, Zhou, Zheng, Zhou, Xue, Yang, Guang, Young, John A.T., Gao, Lu

“…Hepatitis B e antigen (HBeAg) is an important immunomodulator for promoting host immune tolerance during chronic hepatitis B (CHB) infection. In patients with…”
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Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms by Zhou, Zheng, Hu, Taishan, Zhou, Xue, Wildum, Steffen, Garcia-Alcalde, Fernando, Xu, Zhiheng, Wu, Daitze, Mao, Yi, Tian, Xiaojun, Zhou, Yuan, Shen, Fang, Zhang, Zhisen, Tang, Guozhi, Najera, Isabel, Yang, Guang, Shen, Hong C., Young, John A. T., Qin, Ning

“…Heteroaryldihydropyrimidine (HAP) and sulfamoylbenzamide (SBA) are promising non-nucleos(t)ide HBV replication inhibitors. HAPs are known to promote core…”
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Accelerated Preclinical Paths to Support Rapid Development of COVID-19 Therapeutics by Grobler, Jay A., Anderson, Annaliesa S., Fernandes, Prabhavathi, Diamond, Michael S., Colvis, Christine M., Menetski, Joseph P., Alvarez, Rosa M., Young, John A.T., Carter, Kara L.

“…When SARS-CoV-2 emerged at the end of 2019, no approved therapeutics or vaccines were available. An urgent need for countermeasures during this crisis…”
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HIV-1: Fifteen Proteins and an RNA by Frankel, Alan D, Young, John A. T

“…Human immunodeficiency virus type 1 is a complex retrovirus encoding 15 distinct proteins. Substantial progress has been made toward understanding the function…”
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Human host factors required for influenza virus replication by Shaw, Megan L, Chanda, Sumit K, König, Renate, Stertz, Silke, Zhou, Yingyao, Inoue, Atsushi, Hoffmann, H. -Heinrich, Bhattacharyya, Suchita, Alamares, Judith G, Tscherne, Donna M, Ortigoza, Mila B, Liang, Yuhong, Gao, Qinshan, Andrews, Shane E, Bandyopadhyay, Sourav, De Jesus, Paul, Tu, Buu P, Pache, Lars, Shih, Crystal, Orth, Anthony, Bonamy, Ghislain, Miraglia, Loren, Ideker, Trey, García-Sastre, Adolfo, Young, John A. T, Palese, Peter

“…Influenza A virus is an RNA virus that encodes up to 11 proteins and this small coding capacity demands that the virus use the host cellular machinery for many…”
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An integrated map of HIV-human protein complexes that facilitate viral infection by Emig-Agius, Dorothea, Olivieri, Kevin, Pache, Lars, Shih, Hsin Ling, Pustovalova, Olga, Bessarabova, Marina, Young, John A T, Chanda, Sumit K, Ideker, Trey

“…Recent proteomic and genetic studies have aimed to identify a complete network of interactions between HIV and human proteins and genes. This HIV-human…”
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Selective viral vector transduction of ErbB4 expressing cortical interneurons in vivo with a viral receptor—ligand bridge protein by Choi, Jiwon, Young, John A. T., Callaway, Edward M.

“…Both treatment of disease and basic studies of complex tissues can benefit from directing viral vector infection to specific cell types. We have used a unique…”
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