Search Results - "Youker, Robert T."

Disease-relevant mutations alter amino acid co-evolution networks in the second nucleotide binding domain of CFTR by Ivey, Gabrianne, Youker, Robert T

“…Cystic Fibrosis (CF) is an inherited disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel. Mutations in…”
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Correction: Disease-relevant mutations alter amino acid co-evolution networks in the second nucleotide binding domain of CFTR by Ivey, Gabrianne, Youker, Robert T

“…[This corrects the article DOI: 10.1371/journal.pone.0227668.]…”
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Measuring protein dynamics in live cells: protocols and practical considerations for fluorescence fluctuation microscopy by Youker, Robert T, Teng, Haibing

“…Quantitative analysis of protein complex stoichiometries and mobilities are critical for elucidating the mechanisms that regulate cellular pathways…”
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At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis by Youker, Robert T, Shinde, Ujwal, Day, Robert, Thomas, Gary

“…The endomembrane system in mammalian cells has evolved over the past two billion years from a simple endocytic pathway in a single-celled primordial ancestor…”
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Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9-dependent mechanism by Mo, Di, Costa, Simone A, Ihrke, Gudrun, Youker, Robert T, Pastor-Soler, Nuria, Hughey, Rebecca P, Weisz, Ora A

“…The sialomucin endolyn is implicated in adhesion, migration, and differentiation of various cell types. Along rat kidney tubules, endolyn is variously…”
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Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast by Youker, Robert T, Walsh, Peter, Beilharz, Traude, Lithgow, Trevor, Brodsky, Jeffrey L

“…Aberrant secreted proteins can be destroyed by ER-associated protein degradation (ERAD), and a prominent, medically relevant ERAD substrate is the cystic…”
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SubVis: an interactive R package for exploring the effects of multiple substitution matrices on pairwise sequence alignment by Barlowe, Scott, Coan, Heather B, Youker, Robert T

“…Understanding how proteins mutate is critical to solving a host of biological problems. Mutations occur when an amino acid is substituted for another in a…”
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Altered dynamics of a lipid raft associated protein in a kidney model of Fabry disease by Labilloy, Anatália, Youker, Robert T., Bruns, Jennifer R., Kukic, Ira, Kiselyov, Kirill, Halfter, Willi, Finegold, David, Monte, Semiramis Jamil Hadad do, Weisz, Ora A.

“…Accumulation of globotriaosylceramide (Gb3) and other neutral glycosphingolipids with galactosyl residues is the hallmark of Fabry disease, a lysosomal storage…”
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Multiple Biosynthetic Trafficking Routes for Apically Secreted Proteins in MDCK Cells by Mattila, Polly E., Youker, Robert T., Mo, Di, Bruns, Jennifer R., Cresawn, Kerry O., Hughey, Rebecca P., Ihrke, Gudrun, Weisz, Ora A.

“…Many newly synthesized membrane proteins traverse endocytic intermediates en route to the surface in polarized epithelial cells; however, the biosynthetic…”
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Cysteine String Protein Monitors Late Steps in Cystic Fibrosis Transmembrane Conductance Regulator Biogenesis by Zhang, Hui, Schmidt, Bela Z., Sun, Fei, Condliffe, Steven B., Butterworth, Michael B., Youker, Robert T., Brodsky, Jeffrey L., Aridor, Meir, Frizzell, Raymond A.

“…We examined the role of the cysteine string protein (Csp) in cystic fibrosis transmembrane conductance regulator (CFTR) biogenesis in relation to another…”
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Characterization of Spatial Differences in Two Misfolded Proteins During Aggresome Formation by Goldy, Jordan N, Youker, Robert T

“…Cells have evolved an elaborate network of folding and degradation pathways to maintain the native state of proteins. If these pathways are disrupted (e.g.,…”
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HIV-1 Nef Binds PACS-2 to Assemble a Multikinase Cascade That Triggers Major Histocompatibility Complex Class I (MHC-I) Down-regulation: ANALYSIS USING SHORT INTERFERING RNA AND KNOCK-OUT MICE by Atkins, Katelyn M, Thomas, Laurel, Youker, Robert T, Harriff, Melanie J, Pissani, Franco, You, Huihong, Thomas, Gary

“…Human immunodeficiency virus, type 1, negative factor (Nef) initiates down-regulation of cell-surface major histocompatibility complex-I (MHC-I) by assembling…”
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FK506 Binding Protein 8 Peptidylprolyl Isomerase Activity Manages a Late Stage of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Folding and Stability by Hutt, Darren M., Roth, Daniela Martino, Chalfant, Monica A., Youker, Robert T., Matteson, Jeanne, Brodsky, Jeffrey L., Balch, William E.

“…Cystic fibrosis (CF) is caused by mutations in the apical chloride channel cystic fibrosis transmembrane conductance regulator (CFTR) with 90% of patients…”
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Teaching Biochemistry and Molecular Biology with Virtual Reality — Lesson Creation and Student Response by Coan, Heather, Goehle, Geoff, Youker, Robert

“…The commercialization of Virtual Reality (VR) hardware has enabled the use of VR as an educational tool. We describe how a VR platform was used to create…”
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Differential Effects of Oleuropein and Hydroxytyrosol on Aggregation and Stability of CFTR NBD1-ΔF508 Domain by Robinson, Christopher S., Wyderko, Jennifer A., Vang, Yeng, Martin, Galen, Youker, Robert T.

“…Cystic Fibrosis (CF) is caused by loss of function mutations in the Cystic Fibrosis transmembrane conductance regulator (CFTR). The folding and assembly of…”
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Multiple motifs regulate apical sorting of p75 via a mechanism that involves dimerization and higher-order oligomerization by Youker, Robert T, Bruns, Jennifer R, Costa, Simone A, Rbaibi, Youssef, Lanni, Frederick, Kashlan, Ossama B, Teng, Haibing, Weisz, Ora A

“…The sorting signals that direct proteins to the apical surface of polarized epithelial cells are complex and can include posttranslational modifications, such…”
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Akt and 14-3-3 Control a PACS-2 Homeostatic Switch that Integrates Membrane Traffic with TRAIL-Induced Apoptosis by Aslan, Joseph E., You, Huihong, Williamson, Danielle M., Endig, Jessica, Youker, Robert T., Thomas, Laurel, Shu, Hongjun, Du, Yuhong, Milewski, Robert L., Brush, Matthew H., Possemato, Anthony, Sprott, Kam, Fu, Haian, Greis, Kenneth D., Runckel, Douglas N., Vogel, Arndt, Thomas, Gary

“…TRAIL selectively kills diseased cells in vivo, spurring interest in this death ligand as a potential therapeutic. However, many cancer cells are resistant to…”
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Atrazine effects on testosterone levels and androgen-dependent reproductive organs in peripubertal male rats by Trentacoste, S. V, Friedmann, A. S, Youker, R. T, Breckenridge, C. B, Zirkin, B. R

“…Previous studies have reported that atrazine, a widely used herbicide that selectively inhibits photosynthesis in broadleaf and grassy weeds, has adverse…”
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Modulation of Rat Leydig Cell Steroidogenic Function by Di(2-Ethylhexyl)Phthalate by Akingbemi, B T, Youker, R T, Sottas, C M, Ge, R, Katz, E, Klinefelter, G R, Zirkin, B R, Hardy, M P

“…Exposure of rodents to phthalates is associated with developmental and reproductive anomalies, and there is concern that these compounds may be causing adverse…”
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Modulation of Rat Leydig Cell Steroidogenic Function by Di(2-Ethylhexyl)Phthalate1 by Akingbemi, Benson T, Youker, Robert T, Sottas, Chantal M, Ge, Renshan, Katz, Emily, Klinefelter, Gary R, Zirkin, Barry R, Hardy, Matthew P

“…Exposure of rodents to phthalates is associated with developmental and reproductive anomalies, and there is concern that these compounds may be causing adverse…”
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